Exploring the impact of internet use on cognitive abilities in the older adults: evidence from the CHARLS 2020 database.

Introduction: The rapid aging of the global population has increased the prevalence of cognitive impairments, presenting significant challenges for healthcare systems. This study examines the potential protective role of internet use against cognitive decline among older adults in China.

Methods: Utilizing the China Health and Retirement Longitudinal Study (CHARLS 2020) data, this research analyzed a sample of 7,142 Chinese adults aged 60 and above.

Integrated metabolomic and transcriptomic analysis reveals the effects and mechanisms of Jinqi Jiangtang tablets on type 2 diabetes.

Background: Type 2 diabetes (T2DM) is one of the major metabolic diseases and poses a serious challenge to human life and global economic development. Jinqi Jiangtang Tablets (JQJT) is effective in ameliorating the effects of T2DM, but the mechanism of JQJT is unclear.

Purpose: This study integrated metabolomics and transcriptomics to reveal the mechanism by which JQJT improves T2DM.

Direct visualization endoscopic retrograde appendicitis therapy for treatment of acute uncomplicated appendicitis.

Objective: To investigate the diagnostic and therapeutic value of direct visualization (single-use eyeMax subscope) endoscopic management of acute uncomplicated appendicitis.

Methods: Thirty-six patients diagnosed with acute uncomplicated appendicitis, confirmed by computed tomography or ultrasonography, from Jan 2023 to Feb 2024 were enrolled in this study. We collected demographics, colonoscopy findings, subscope findings, clinical outcomes of endoscopic retrograde appendicitis therapy (ERAT), and adverse events associated with ERAT.

Inflammation and coronary microvascular disease: relationship, mechanism and treatment.

Coronary microvascular disease (CMVD) is common in patients with cardiovascular risk factors and is linked to an elevated risk of adverse cardiovascular events. Although modern medicine has made significant strides in researching CMVD, we still lack a comprehensive understanding of its pathophysiological mechanisms due to its complex and somewhat cryptic etiology. This greatly impedes the clinical diagnosis and treatment of CMVD.

Heralded quantum multiplexing entanglement between stationary qubits via distribution of high-dimensional optical entanglement.

Quantum entanglement between pairs of remote quantum memories (QMs) is a prerequisite for realizing many applications in quantum networks. Here, we present a heralded protocol for the parallel creation of quantum entanglement among multiple pairs of QMs placed in spatially separated nodes, where each QM, encoding a stationary qubit, couples to an optical cavity and deterministically interacts with single photons. Our protocol utilizes an entangled photon pair encoded in the high-dimensional time-bin degree of freedom to simultaneously entangle multiple QM pairs, and is efficient in terms of reducing the time consumption and photon loss during transmission.

LncIRF1 promotes chicken resistance to ALV-J infection.

Unlabelled: The pathogenesis of avian leukosis virus subgroup J (ALV-J) is complex and our understanding of it is limited. Based on our previous research, we explored the relationship between ALV-J infection and regulatory factor 1&7 ( and ), interferon beta (), and the newly identified long noncoding RNA IRF1 (). is 1603 nt and exists in the cytoplasm and nucleus.

Coupling and coordinated development of low-carbon economy and green finance: an empirical study of the Yangtze River Delta region in China.

The introduction of China's double carbon target has led to a new stage in the development of China's low-carbon economy, while the development of China's green finance is also facing new challenges. Based on the determining of the relationship between low-carbon economy and green finance, this study selected the Yangtze River Delta city cluster of China, an exemplary region for the development of low-carbon economy and green finance, constructed a multi-level comprehensive index system covering two systems of low-carbon economy and green finance and conducted a coupled and coordinated relationship analysis based on the panel data of green finance and low-carbon economy-related indicators from 2016 to 2020. The empirical results showed that the interaction between the low-carbon economy system and the green finance system in the Yangtze River Delta region gradually weakened during 2016-2020, and the mechanism of interaction between the two systems has not been fully developed and utilized.

Targeting mitochondrial circadian rhythms: The potential intervention strategies of Traditional Chinese medicine for myocardial ischaemia‒reperfusion injury.

Coronary artery disease has one of the highest mortality rates in the country, and methods such as thrombolysis and percutaneous coronary intervention (PCI) can effectively improve symptoms and reduce mortality, but most patients still experience symptoms such as chest pain after PCI, which seriously affects their quality of life and increases the incidence of adverse cardiovascular events (myocardial ischaemiareperfusion injury, MIRI). MIRI has been shown to be closely associated with circadian rhythm disorders and mitochondrial dysfunction. Mitochondria are a key component in the maintenance of normal cardiac function, and new research shows that mitochondria have circadian properties.

Targeting metabolic pathways: a novel therapeutic direction for type 2 diabetes.

Background: Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disease that causes multi-organ complications, seriously affecting patients' quality of life and survival. Understanding its pathogenesis remains challenging, with current clinical treatment regimens often proving ineffective.

Methods: In this study, we established a mouse model of T2DM and employed 16s rDNA sequencing to detect changes in the species and structure of gut flora.

Gut microbiota: A new target of traditional Chinese medicine for insomnia.

All species have a physiological need for sleep, and sleep is crucial for the preservation and restoration of many physiological processes in the body. Recent research on the effects of gut microbiota on brain function has produced essential data on the relationship between them. It has been discovered that dysregulation of the gut-brain axis is related to insomnia.

The add-on effect of Shufeng Jiedu capsule for treating COVID-19: A systematic review and meta-analysis.

Introduction: Shufeng Jiedu capsule (SFJD) is a commonly used Chinese patent medicine in China. Some studies have reported that SFJD has therapeutic effects in patients diagnosed with COVID-19. This systematic review aimed to critically evaluate the efficacy and safety of SFJD combined with western medicine (WM) for treating COVID-19.

Rotating Single-Antenna Spoofing Signal Detection Method Based on IPNN.

The traditional carrier-phase differential detection technology mainly relies on the spatial processing method, which uses antenna arrays or moving antennas to detect spoofing signals, but it cannot be applied to static single-antenna receivers. Aiming at this problem, this paper proposes a rotating single-antenna spoofing signal detection method based on the improved probabilistic neural network (IPNN). When the receiver antenna rotates at a constant speed, the carrier-phase double difference of the real signal will change with the incident angle of the satellite.

Blockage of MLKL prevents myelin damage in experimental diabetic neuropathy.

SignificanceDiabetic neuropathy is a commonly occurring complication of diabetes that affects hundreds of millions of patients worldwide. Patients suffering from diabetic neuropathy experience abnormal sensations and have damage in their peripheral nerve axons as well as myelin, a tightly packed Schwann cell sheath that wraps around axons to provide insulation and increases electrical conductivity along the nerve fibers. The molecular events underlying myelin damage in diabetic neuropathy are largely unknown, and there is no efficacious treatment for the disease.

Utilization of Soybean Oil Waste for a High-Level Production of Ceramide by a Novel Phospholipase C as an Environmentally Friendly Process.

Ceramide is a natural functional ingredient as food additive and medicine that has attracted extensive attention in the food, medical, and cosmetic industries. Here, we developed a biotechnological strategy based on a recombinant whole-cell biocatalyst for efficiently producing ceramide from crude soybean oil sediment (CSOS) waste. A novel phospholipase C (PLC) from isolated from soil samples was identified and characterized.

Biochemical characterization of a tyrosinase from Bacillus aryabhattai and its application.

Although lots of tyrosinases have been isolated from bacteria, few studies are focused on tyrosinases from Bacillus sp.. In this study, a tyrosinase from B.

Enhancing the functional characteristics of soy protein isolate via cross-linking catalyzed by Bacillus subtilis transglutaminase.

Background: Although Streptomyces mobaraense transglutaminase (MTG) has been extensively applied to enhance the functional characteristics of soy protein isolate (SPI) through cross-linking, various transglutaminases (TGs) in nature may provide more choice in the food industry. Previous research reported that TG derived from Bacillus subtilis (BTG) exhibited better pH stability and thermostability than MTG.

Results: An attempt was made to study the influence of BTG induced cross-linking on the properties of SPI.

Enzymatic characterization, molecular dynamics simulation, and application of a novel Bacillus licheniformis laccase.

A new laccase gene from newly isolated Bacillus licheniformis TCCC 111219 was actively expressed in Escherichia coli. This recombinant laccase (rLAC) exhibited a high stability towards a wide pH range and high temperatures. 170% of the initial activity was detected at pH 10.

SNP of gene in three cattle breeds using snapshot technology.

Droughtmaster is a tropical breed of beef cattle that can survive in hot climates and easily adapt to torrid environments. These traits are important in livestock breeding. In this study, we genotyped five single-nucleotide polymorphisms (SNPs) of the gene from 190 cattle belonging to three different breeds (Droughtmaster, Angus and Simmental) by using snapshot technology.

Photocatalytic degradation of methylene blue by a cocatalytic PDA/TiO electrode produced by photoelectric polymerization.

This study reports a new method for photocatalysts to degrade organic dyes on organic semiconductors. A novel strategy is reported to form TiO nanorod (NR)/polydopamine (PDA) electrodes with a photoelectric polymerization strategy for PDA (pep-PDA) to produce cocatalytic electrodes. Amperometric - curves and UV-vis diffuse reflectance spectra were recorded and showed that compared with traditional self-polymerization (sp-PDA) and electropolymerization (ep-PDA), TiO NR/pep-PDA exhibited an enhanced photocatalytic activity under visible light.

Preparation of Microcapsules Coating and the Study of Their Bionic Anti-Fouling Performance.

With the increasing demands to better the marine environment, environmentally friendly anti-fouling coatings have attracted attention from society. Adding hydrolyzable microcapsules without toxin to paints is a very useful and safe method to get bionic anti-fouling coatings with a micro-nano surface structure. Based on this trend, a form of environment-friendly microcapsules were prepared through mini-emulsion polymerization.