Publications by authors named "Zehua Dai"
Targeting the DNA repair pathway for breast cancer therapy: Beyond the molecular subtypes.
Biomed Pharmacother
December 2023
Article Synopsis
- DNA repair is essential for cell health, preventing DNA damage that can lead to cancer; dysfunctions in this process are linked to cancer development.
- Advances in targeted therapy, particularly with PARP1 inhibitors, show promise for treating breast cancer in patients with BRCA1/2 mutations, highlighting the importance of the DNA repair signaling pathway.
- The review outlines current research on BRCA-related treatments, evaluations of various DNA repair inhibitors, and their clinical implications for different breast cancer subtypes, while also forecasting future developments in cancer therapy.
Stanniocalcin-1 (STC1) is a glycoprotein hormone whose abnormal expression has been reported to be associated with a variety of tumors, but its function in breast cancer is not well understood. Through modulation of STC1 expression in different breast cancer cell lines, our study found that STC1 could promote the proliferation and growth of breast cancer cells and promote metastasis. Furthermore, STC1 reduced apoptosis induction by irradiation.
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