Publications by authors named "Zehu Chen"
Chest CT assess the impact of omalizumab treatment on airway remodeling in refractory asthma.
Pulm Pharmacol Ther
December 2024
Background: To evaluate the benefits of omalizumab treatment in patients through real-world follow-up and assess the impact of omalizumab treatment on airway remodeling using chest CT.
Methods: This is a single-center prospective, observational study included Chinese patients with refractory asthma who received omalizumab treatment from May 2021 to December 2022. We collected real-world clinical data, including their hospitalization information, pulmonary function, FENO, laboratory assessment, ACT scores, chest CT at baseline and every follow-up month.
Article Synopsis
- Epidemiological studies suggest a link between rheumatoid arthritis (RA) and bronchiectasis; this study uses a two-sample Mendelian randomization analysis to examine whether RA causes bronchiectasis or vice versa.
- Results indicate that a genetic predisposition to RA increases the risk of bronchiectasis in both European and East Asian populations, with consistent findings across various analytical methods.
- The absence of genetic causality from bronchiectasis to RA implies that monitoring for bronchiectasis in RA patients could be useful, and managing RA might lower the risk of developing bronchiectasis.
Background: Interleukin-33 (IL-33) exacerbates asthma probably through type 2 innate lymphoid cells (ILC2s). Nevertheless, the association between eosinophilic asthma (EA) and ILC2s remains obscure, and the mechanisms by which IL-33 affects ILC2s are yet to be clarified.
Methods: ILC2s were evaluated in peripheral blood mononuclear cells, induced sputum, and bronchoalveolar lavage fluid obtained from patients with EA.