Publications by authors named "Zehra Topal Suzan"
In this study, we aimed to evaluate the potential effects of white tea (WT) in the atherosclerosis process characterized by oxidative stress, inflammation, and dyslipidemia. In our study, apolipoprotein E knockout (ApoE) mice (RRID: IMSR_JAX:002052) and C57BL/6J mice (RRID: IMSR_JAX:000664) were used. In the atherosclerosis model induced by an atherogenic diet (AD), WT was administered via oral gavage at two different concentrations.
View Article and Find Full Text PDFAim: Nowadays, the electromagnetic field (EMF) has become an issue of electromagnetic pollution. This study aimed to determine the effect of 5 G Fr1 frequency band EMF waves on endoplasmic reticulum (ER) stress in testicular tissue and to demonstrate the efficacy of coenzyme Q10 (CoQ10) in suppressing the potential situation.
Materials And Methods: Three groups of eight male Sprague-Dawley rats were established.
Acute kidney injury (AKI) is a severe medical condition that can lead to illness and death. A disintegrin and metalloprotease (ADAM) protein family is a potential treatment target for AKI due to its involvement in inflammation, growth, and differentiation. While ADAM10 and ADAM17 have been identified as significant contributors to inflammation, it is unclear whether they play a critical role in AKI.
View Article and Find Full Text PDFArticle Synopsis
- The study examined the impact of new generation Doppler ultrasonography (DUSG) on renal development in male rat pups, comparing groups exposed to daily versus every two days applications of DUSG during pregnancy to a control group.
- Results indicated that both DUSG groups exhibited higher levels of malondialdehyde, glutathione, and other biochemical markers, as well as increased tubular damage and Caspase-3 expression, suggesting adverse effects on kidney development.
- The findings emphasize the need for caution in using DUSG during pregnancy, recommending shorter exposure times and limiting frequency of applications to mitigate harmful effects on fetal organ development.
Background: Gadolinium-based contrast agents are complex chelates to provide contrast in NRI. However, recent studies have highlighted the deposition of free Gd ion in various tissues.
Purpose: To evaluate the histopathological and immunohistochemical changes on rat kidney tissue following both macrocyclic (gadoteric acid) and linear (gadodiamide) agents under the hypothesis that gadolinium-based contrast agents (GBCA) lead to toxic, free Gd accumulation in tissues.
Background: MRI with contrast is often used clinically. However, recent studies have reported a high accumulation of gadolinium-based contrast agents (GBCAs) in kidney, liver, and spleen tissues in several mouse models.
Purpose: To compare the effects on liver tissue of gadolinium-based MRI contrast agents in the light of biochemical and histopathological evaluation.