Publications by authors named "Zehra Seda Unal Halbutogulları"
Article Synopsis
- The Endoplasmic Reticulum (ER) helps cells do important jobs, and if something goes wrong, it can cause stress in the cell.
- Researchers studied how two different doses of a drug called Thapsigargin (Tg) affect seizure activity and certain proteins in the brains of rats that have absence seizures.
- They found that a mild dose of Tg increased seizure activity and changed protein levels, while a high dose reduced seizures but increased certain inflammatory markers, showing that different doses of Tg can have different effects on seizures and cell responses.
Aromatase enzyme plays an essential role in estrogen-induced tumorigenesis. It is expressed in the normal pituitary and more significantly in prolactinoma tissues. The aim of this study was to investigate the effects of an aromatase inhibitor, letrozole, on MMQ and GH3 rat prolactinoma cell lines and evaluate the possible mechanism of action.
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- Middle ear cholesteatoma is a benign yet invasive condition that is primarily treated with surgery, and there's currently no medical alternative available.
- The study involved creating a 3D cholesteatoma model from tissue samples of four patients to test the effects of diclofenac sodium on cell viability and proliferation.
- Results showed that diclofenac sodium reduced cell viability and proliferation while increasing apoptosis, suggesting potential for medical treatment, but further research on its safety is necessary.