Publications by authors named "Zehra Ordulu Sahin"
Article Synopsis
- Chemotherapies may induce cell death by elevating levels of reactive oxygen species (ROS), but the specific mechanisms and proteins involved are not fully understood.* -
- Researchers investigated 11 different chemotherapies and discovered both unique and common protein targets, such as ribosomal components, highlighting a potential method through which these drugs affect protein translation.* -
- The study centered on the protein CHK1, which plays a role in sensing nuclear hydrogen peroxide (H2O2) and regulates mitochondrial function, revealing a pathway that can help cancer cells resist platinum-based chemotherapy in ovarian cancers.*
As intrapartum fevers are not always infectious in origin, determining whether antibiotics are indicated is challenging. We previously sought to create a point-of-care calculator using clinical data available at the time of an intrapartum fever to identify the subset of women who require antibiotic treatment to avoid maternal and neonatal morbidity. Despite the use of a comprehensive dataset from our institutions, we were unable to propose a valid and highly predictive model.
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