Does having COVID-19 infection history lead to a different clinical presentation and treatment response in patients with major depression?

Objective: This study aimed to investigate whether a history of Coronavirus disease 2019 (COVID-19) affects depression severity, symptoms, and treatment response in patients with major depressive disorder (MDD).

Methods: The study included 76 patients with a history of COVID-19 and 98 patients without, all diagnosed with first-episode MDD. After one month, 32 patients with and 36 without a history of COVID-19 were re-evaluated.