Publications by authors named "Zehong Song"
Article Synopsis
- Systemic sclerosis (SSc) is an autoimmune disease linked to loss of subcutaneous adipose tissue (SAT), with miR-4769-3p identified as a key factor affecting adipogenesis.
- Silencing miR-4769-3p in SSc mouse models and 3T3-L1 cells promoted SAT recovery and enhanced adipogenesis, while its overexpression had the opposite effect.
- The study suggests that miR-4769-3p inhibits adipogenesis by negatively regulating the USP18/VDAC2 pathway, indicating a potential therapeutic target for improving SAT loss in SSc.
Fibrosis is a pathological phenomenon characterized by the aberrant accumulation of extracellular matrix (ECM) in tissues. Fibrosis is a universally age-related disease involving that many organs and is the final stage of many chronic inflammatory diseases, which often threaten the patient's health. Undoubtedly, fibrosis has become a serious economic and health burden worldwide, However, the pathogenesis of fibrosis is complex.
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