Publications by authors named "Zefa Lu"
Article Synopsis
- The study investigates genetic differences between two types of cholangiocarcinoma: perihilar (pCCA) and intrahepatic (iCCA) cancers, using exome-sequencing data from various Asian centers.
- Findings show that iCCA has a higher mutation and copy number alteration burden compared to pCCA, with high alterations linked to poorer outcomes in pCCA.
- Researchers identified key mutated genes, including METTL14, which plays a role in RNA modifications and may influence cancer progression, suggesting significant genomic diversity and its impact on cholangiocarcinoma development.
Tip60 Suppresses Cholangiocarcinoma Proliferation and Metastasis via PI3k-AKT.
Cell Physiol Biochem
November 2018
Background/aims: Aberrant expression of Tip60 is associated with progression in many cancers. However, the role of Tip60 in cancer progression remains contradictory. The aim of this study was to investigate the clinical significance, biological functions and underlying mechanisms of Tip60 deregulation in cholangiocarcinoma (CCA) for the first time.
View Article and Find Full Text PDFBackground & Aims: Aberrant expression of microRNAs is associated with many cancers progression. Many studies have shown that miR-16 is down-regulated in many cancers. However, its role in cholangiocarcinoma (CCA) is unknown.
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