N-linoleyltyrosine resisted the growth of non-small cell lung cancer cells via the regulation of CB and CB involvement of PI3K and ERK pathways.

N-linoleyltyrosine (NITyr), one of the anandamide analogs, exerts activity via the endocannabinoid receptors (CB and CB), which showed anti-tumor effects in various tumors. Therefore, we speculated that NITyr might show anti-non-small cell lung cancer (NSCLC) effects via the CB or CB receptor. The purpose of the investigation was to reveal the anti-tumor ability of NITyr on A549 cells and its mechanisms.

Sedimentary evolution of PAHs, POPs and ECs: Historical sedimentary deposition and evolution of persistent and emerging organic pollutants in sediments in a typical karstic river basin.

Knowledge on the occurrence and distributions of organic compounds, especially PAHs, POPs and ECs, in karstic river basins is limited. This study aims to determine the depositional history and sources of PAHs, PCBs, OCPs, antibiotics, EDCs and phenolic compounds and the ecological risk they have in the Panyang River Basin, an area with a typical karstic landscape and a high-longevity population. Sediment core analysis was adopted, correlation and principal component analyses were conducted to analyze pollution sources, and lead isotope technology was implemented for dating analysis.