Publications by authors named "Zechen Jin"

Article Synopsis
  • - The study focuses on developing necroptosis inhibitors to address various inflammatory diseases, neurodegenerative diseases, and cancers, highlighting their potential therapeutic benefits.
  • - Researchers introduced a specific compound, 26, which shows strong anti-necroptotic effects in both human and mouse cells by effectively inhibiting receptor-interacting protein kinase 1 (RIPK1).
  • - Pharmacokinetic studies and molecular docking revealed that compound 26 can bind well to RIPK1’s allosteric pocket, marking it as a promising candidate for future necroptosis inhibitor research.
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Stimulator of interferon gene (STING) plays critical roles in the cytoplasmic DNA-sensing pathway and in the induction of inflammatory response. Aberrant cytoplasmic DNA accumulation and STING activation are implicated in numerous inflammatory and autoimmune diseases. Here, we reported the discovery of a series of thiazolecarboxamide-based STING inhibitors through a molecular planarity/symmetry disruption strategy.

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Five fluorescent probes TP1-5 were demonstrated as two-input "AND" molecular logic gates for the detection of thiols and protons. The molecules were designed based on "thiol receptor-spacer-fluorophore-spacer-proton receptor" mode. The logic gates were constructed by employing maleimide, naphthalimide and morpholine (TP1-3)/-methyl piperazine (TP4-5) as the thiol receptor, fluorophore and proton receptor, respectively.

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This paper introduced the application of support vector machines(SVM) regression method based on statistics studytheory to the quantitative analysis with near-infrared (NIR) spectroscopy. Sixty-six wheat samples were used as experimental materials, and thirty-three of them were used as calibration samples. The protein contents and NIR spectra of the calibration samples were used to build SVM regression models by four different kernel functions.

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