Co-doped bismuth vanadate/zinc tungstate heterojunction with dual internal electric fields for efficient photocatalytic reduction of carbon dioxide.

Enhanced carriers separation on photocatalysts is crucial for improving photocatalytic activity. In this paper, the Co-doped BiVO/ZnWO S-scheme heterojunctions were constructed to induce double internal electric fields (IEFs) for enhancing charges separation and transfer for efficient photocatalytic reduction of CO. The photocatalytic CO reduction efficiencies of the heterojunctions were significantly enhanced as compared with the counterparts.

Electrochemical reconfiguration of iron-modified NiS surface induced oxygen vacancies to immobilize sulfate for enhanced oxygen evolution reaction.

There is an urgent need for highly active, durable, and low-cost electrocatalysts to overcome the shortcomings of high overpotential in the oxygen evolution reaction (OER) process. In this work, the nickel-iron hydroxysulfate rich in sulfate and oxygen vacancies (SO@Fe-NiOOH-O/NiS) is legitimately constructed. SO@Fe-NiOOH-O/NiS only requires a low overpotentials of 190 mV and 232 mV at 10 mA cm and 100 mA cm current densities in 1 M KOH, with excellent stability for 200 h at 100 mA cm current density.

Adhesion GPCR ADGRE2 Maintains Proteostasis to Promote Progression in Acute Myeloid Leukemia.

Acute myeloid leukemia (AML) is an aggressive and heterogeneous hematologic malignancy. In elderly patients, AML incidence is high and has a poor prognosis due to a lack of effective therapies. G protein-coupled receptors (GPCR) play integral roles in physiologic processes and human diseases.

Hematopoietic stem and progenitor cell membrane-coated vesicles for bone marrow-targeted leukaemia drug delivery.

Leukemia is a kind of hematological malignancy originating from bone marrow, which provides essential signals for initiation, progression, and recurrence of leukemia. However, how to specifically deliver drugs to the bone marrow remains elusive. Here, we develop biomimetic vesicles by infusing hematopoietic stem and progenitor cell (HSPC) membrane with liposomes (HSPC liposomes), which migrate to the bone marrow of leukemic mice via hyaluronic acid-CD44 axis.

Exploration of the mechanism of levofloxacin removal by N-doped-induced interfacial micro-electric field-activated persulfate.

The defects formed by N doping always coexist with pyrrole nitrogen (Po) and pyridine nitrogen (Pd), and the synergistic mechanisms of HO production and PMS activation between the different Po: Pd are unknown. This paper synthesized MOF-derived carbon materials with different nitrogen-type ratios as cathode materials in an electro-Fenton system using precursors with different nitrogen-containing functional groups. Several catalysts with different Po: Pd ratios (0:4, 1:3, 2:2, 3:1, 4:0) were prepared, and the best catalyst for LEV degradation was FC-CN .

Phase separation-competent FBL promotes early pre-rRNA processing and translation in acute myeloid leukaemia.

RNA-binding proteins (RBPs) are pivotal in acute myeloid leukaemia (AML), a lethal disease. Although specific phase separation-competent RBPs are recognized in AML, the effect of their condensate formation on AML leukaemogenesis, and the therapeutic potential of inhibition of phase separation are underexplored. In our in vivo CRISPR RBP screen, fibrillarin (FBL) emerges as a crucial nucleolar protein that regulates AML cell survival, primarily through its phase separation domains rather than methyltransferase or acetylation domains.

Ultrathin layer TAFC on BiVO with ligand-to-metal charge transfer enhances built-in electric field for boosting photoelectrochemical water oxidation.

To reveal the mechanism of charge transfer between interfaces of BiVO-based heterogeneous materials in photoelectrochemical water splitting system, the cocatalyst was grown in situ using tannic acid (TA) as a ligand and Fe and Co ions as metal centers (TAFC), and then uniformly and ultra-thinly coated on BiVO to form photoanodes. The results show that the BiVO/TAFC achieves a superior photocurrent density (4.97 mA cm at 1.

Class I HDAC inhibitors enhance antitumor efficacy and persistence of CAR-T cells by activation of the Wnt pathway.

Epigenetic modification shapes differentiation trajectory and regulates the exhaustion state of chimeric antigen receptor T (CAR-T) cells. Limited efficacy induced by terminal exhaustion closely ties with intrinsic transcriptional regulation. However, the comprehensive regulatory mechanisms remain largely elusive.

Anthraquinone-based polymer modified BiVO photoanode with strong electron-withdrawing functional groups for boasting photoelectrochemical water oxidation.

The photoelectrochemical (PEC) performance ofBiVO is limited by sluggish water oxidation kinetics and severe carrier recombination. Herein, a novel high-performance BiVO/NiFe-NOAQ photoanode is prepared by a simple one-step hydrothermal method, using BiVO and 1-Nitroanthraquinone (NOAQ) as raw materials. The BiVO/NiFe-NOAQ photoanode has an excellent photocurrent density of 5.

Inducing spin polarization via Co doping in the BiVO cell to enhance the built-in electric field for promotion of photocatalytic CO reduction.

The efficiency of CO photocatalytic reduction is severely limited by inefficient separation and sluggish transfer. In this study, spin polarization was induced and built-in electric field was strengthened via Co doping in the BiVO cell to boost photocatalytic CO reduction. Results showed that owing to the generation of spin-polarized electrons upon Co doping, carrier separation and photocurrent production of the Co-doped BiVO were enhanced.

Decoding leukemia at the single-cell level: clonal architecture, classification, microenvironment, and drug resistance.

Leukemias are refractory hematological malignancies, characterized by marked intrinsic heterogeneity which poses significant obstacles to effective treatment. However, traditional bulk sequencing techniques have not been able to effectively unravel the heterogeneity among individual tumor cells. With the emergence of single-cell sequencing technology, it has bestowed upon us an unprecedented resolution to comprehend the mechanisms underlying leukemogenesis and drug resistance across various levels, including the genome, epigenome, transcriptome and proteome.

NiFe MOF modified BiVO photoanode with strong π-π conjugation enhances built-in electric field for boasting photoelectrochemical water oxidation.

The photoelectrochemical (PEC) performance ofBiVO is limited by sluggish kinetics and poor stability. In this work, a novel high-performance BiVO/NiFe MOF(BPDC) photoanode is constructed by loading NiFe MOF with biphenyl-4,4'-dicarboxylic acid (BPDC) as an organic ligand on BiVO by a simple one-step hydrothermal method. The XPS, OCP, UPS, and KPFM show that the enhanced π-π conjugation effect causes more electrons transfer from the BiVO to the MOFs and affects the magnitude of the work function, leading to a strong built-in electric field to drive carrier separation and migration.

Sn and dual-oxygen-vacancy in the Z-scheme BiSnO/Sn/NiAl-layered double hydroxide heterojunction synergistically enhanced photocatalytic activity toward carbon dioxide reduction.

Photocatalytic conversion of carbon dioxide (CO) into high value-added chemicals is an attractive yet challenging process, primarily due to the readily recombination of hole-electron pairs in photocatalysts. Herein, dual-oxygen-vacancy mediated Z-scheme BiSnO/Sn/NiAl-layered double hydroxide (V-20BSL) heterojunctions were hydrothermally synthesized and subsequently modified with Sn monomers to enhance photocatalytic activity toward CO reduction. The abundance of oxygen vacancies endowed the V-20BSL with extended optical adsorption, enhanced charges separation, and superior CO adsorption and activation.

Electrochemical surface reconstruction of Prussian blue-modified nickel sulfide to form iron-nickel bilayer hydroxyl oxides for efficient and stable oxygen evolution reaction processes.

The oxygen evolution reaction (OER) is an important semi-reaction in the electrocatalytic water splitting for hydrogen energy production, and the development of efficient and low-cost electrocatalysts to solve the problem of slow 4-electron transport kinetics in the OER process is key. In this work, a pre-electrocatalyst with the heterogeneous interfacial structure, Prussian blue-modified nickel sulfide with sulfur vacancies (PB/NS-S), was designed and then converted to iron-nickel bilayer hydroxyl oxides in oxygen-rich vacancies (FeOOH/NiOOH-O@NS) through electrochemical oxidative reconstruction to obtain a truly stable and efficient active material. The study utilized in situ Raman to observe the transition from PB/NS-S to FeOOH/NiOOH-O@NS during the reaction.

Redox-active ligands enhance oxygen evolution reaction activity: Regulating the spin state of ferric ions and accelerating electron transfer.

Metal-organic frameworks (MOFs) are considered as one of the most promising catalysts for oxygen evolution reaction (OER). However, only a few have introduced redox-active ligands into MOFs and explored their role in the OER process. In this work, we synthesized FeNi DHBQ/NF using the redox-active ligand 2,5-dihydroxy-1,4-benzoquinone (DHBQ), which exhibited excellent redox activity and required only 207 and 242 mV overpotentials to achieve current densities of 10 and 100 mA cm.

Adjusting the valence band center of Co-Ni-bimetallic sulfides through lattice expansion and stacking faults triggered by strain engineering to boost oxygen evolution reaction.

Stress engineering can improve catalytic performance by straining the catalyst lattice. An electrocatalyst, CoS/NiS-10%Mo@NC, was prepared with abundant lattice distortion to boost oxygen evolution reaction (OER). With the assistance of the intramolecular steric hindrance effect of metal-organic frameworks, slow dissolution by MoO of the Ni substrate and recrystallization of Ni was observed in the process of Co(OH)F crystal growth with mild temperature and short time reaction.

AMLnet, A deep-learning pipeline for the differential diagnosis of acute myeloid leukemia from bone marrow smears.

Acute myeloid leukemia (AML) is a deadly hematological malignancy. Cellular morphology detection of bone marrow smears based on the French-American-British (FAB) classification system remains an essential criterion in the diagnosis of hematological malignancies. However, the diagnosis and discrimination of distinct FAB subtypes of AML obtained from bone marrow smear images are tedious and time-consuming.

Unraveling the π-interaction of NiFe-based metal-organic frameworks with enhanced oxygen evolution: Optimizing electronic structure and facilitating electron transfer modulation.

Metal-organic frameworks (MOFs) with conjugation carboxylate ligands as electrocatalysts can significantly improve oxygen evolution reaction (OER), but the role of π-interaction on the reactive sites of OER is often neglected. We intend to unravel the mechanism of how π-interaction enhances OER performance. The results of Rietveld refinement, density functional theory (DFT) calculations, and in-situ Raman spectra show that π-interaction can efficiently modulate the local spin configuration of metal centers, facilitate γ-NiFeOOH active species with high-valence Ni sites modified by high-spin Fe, accelerate electron transfer, optimize the d-band center together with the beneficial rate-determining step of OER.

Ultrahigh-efficient BiOBr-x%La@y%CNQDs nanocomposites with enhanced generation and separation of photogenerated carriers towards bisphenol A degradation and toxicity reduction.

In this study, a series of hierarchical flower-like La-doped BiOBr composites modified with carbon nitride quantum dots (BiOBr-x%La@y%CNQDs) was synthesized using a microwave solvothermal method in combination with a calcination method. It was found that La doping and CNQDs co-decorated with BiOBr showed much better photoreactivity for bisphenol A (BPA) degradation than pure BiOBr. The best degradation and mineralization efficiencies of BPA were 100% and 77% within 12 min at La and CNQDs contents of 1% and 1.