Publications by authors named "Zebao Qiu"
Int Immunopharmacol
December 2024
Article Synopsis
- Sepsis-associated encephalopathy (SAE) leads to severe cognitive issues, and recent research indicates that ferroptosis, a type of cell death linked to iron and lipid processes, may be involved in SAE's effects on the brain.
- The study shows that knocking out the Nrf2 gene worsens cognitive and emotional impairments in a mouse model of SAE and promotes brain injury and ferroptosis by increasing oxidative stress and inflammatory markers.
- Overexpressing Nrf2 appears to protect against these effects by improving mitochondrial function and reducing neuroinflammation, suggesting that targeting Nrf2 could be a promising approach for treating cognitive dysfunction in SAE.
