[Application of reversed pedicled submental island flap].

Objective: To explore the clinical applications of reversed pedicled submental island flap in the face and oropharynx.

Methods: The clinical data of ten cases of reconstruction of defect in the area of face or oropharynx following resection of tumors with reversed pedicled submental island flaps between January of 2004 to December of 2006 were retrospectively studied. The cases included six males and four females, aged from 24 to 76 (median 55 years).

[Apoptosis in nasopharyngeal carcinoma cell line NCE induced by curcumin and its molecular mechanism].

Objective: To investigate the mechanism underlying the curcumin-induced apoptosis of nasopharyngeal carcinoma (NPC) cell line NCE cells.

Methods: The characteristics of apoptosis were identified by observation acridine orange and ethidium bromide stains, ultrastructure assay, DNA fragmentation assay and TdT-mediated dUTP nick end labeling method (TUNEL). Mitochondrial membrane potential (delta psi m), activity of caspase-3, cytosol cytochrome C and expression of gene Fas were determined by flow cytometry (FCM), Western Blot and reverse transcription-polymerase chain reaction (RT-PCR).

[Surgical treatment of transcranial middle cranial fossa-lateral skull base malignant tumor].

Objective: To evaluate the surgical method of transcranial middle cranial fossa-lateral skull base malignant tumor.

Methods: Sixteen patients with transcranial middle cranial fossa-lateral skull base malignant tumors were treated by three surgical methods. (1) Postauricular "C" form incision, combined with subtotal resection of temporal bone and high lateral neck approach to resect tumors located in middle cranial fossa, lateral skull base, and parotid region.

[Resection of malignant tumors of the anterior skull base and the fronto-orbito-ethmoidal region by overturn of frontonasal flap].

Objective: To introduce a better surgical approach for the resection of malignant tumors in the anterior skull base and in the fronto-orbito-ethmoidal region.

Methods: A "U" form incision on the bilateral superciliary arch was made and connected with the unhealthy nasal side incision. Then the frontal musculocutaneous flap was over-turned upward.