Publications by authors named "Ze-huan Liu"
Cucurbitacins, the natural triterpenoids possessing many biological activities, have been reported to suppress the mTORC1/p70S6K pathway and to induce autophagy. However, the correlation between such activities is largely unknown. In this study, we addressed this issue in human cancer cells in response to cucurbitacin E (CuE) treatment.
View Article and Find Full Text PDFGraves' disease (GD) is a common polygenic multifactorial autoimmune disease. Toll-like receptors (TLRs) play critical roles in the activation of innate and adaptive immune responses. This study investigated the association of TLR7 and TLR8 gene polymorphisms with susceptibility of GD.
View Article and Find Full Text PDFGraves' disease (GD) is postulated to be caused by the combined effects of susceptibility genes and environmental triggers. Toll-like receptors (TLRs) play a role in the activation of innate and adaptive immune responses in mammalians. The aim of this study was to evaluate the potential association of polymorphisms in TLR1, TLR6 and TLR10 genes with GD in Chinese Cantonese population.
View Article and Find Full Text PDFGraves' disease (GD) is postulated to be caused by the combined effects of susceptibility genes and environmental triggers. Toll like receptors (TLRs) play a role in the activation of innate and adaptive immune responses in mammalians. The aim of this study was to evaluate the potential association of TLR4 and TLR5 gene polymorphisms with GD in Chinese Cantonese population.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the HLA-DRB1 gene polymorphism in the Lahu ethnic group of Yunnan, China, using a high-resolution PCR-SBT method, revealing 16 different alleles among 55 individuals.
- The most common alleles found were HLA-DRB1 *12021, *09012, and *15011, which together comprised 60% of the total alleles, with several alleles being unique to this study and rare globally.
- By comparing HLA-DRB1 frequencies across ethnic groups and constructing a phylogenetic tree, the research concludes that the Lahu ethnic group belongs to the southern Chinese population, rather than originating from northern ethnic groups, providing explanations
In the present study, DNA typing for HLA-DRB1, DQB1 and DPB1 was performed using polymerase chain reaction-sequencing based typing (PCR-SBT) method in 144 random selected Jing ethnic individuals inhabiting in South China. Allele frequencies and two-locus haplotypes (DRB1-DQB1) were statistically analyzed and 20 DPB1 alleles, 27 DRB1 and 20 DQB1 were detected. The most frequent DPB1 allele was DPB1*0501 with the percentage of 36.
View Article and Find Full Text PDF[Association of HLA-DPB1 alleles with chronic myelogenous leukemia in southern Chinese Hans].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
June 2003
To clarify the association between HLA-DPB1 alleles and chronic myelogenous leukemia (CML) in South Chinese, the allelic types of HLA-DPB1 were detected by sequence based typing (SBT) in 86 patients with CML and 82 healthy individuals from Southern China. The results showed that the frequencies of HLA-DPB1 * 1301 and DPB1 * 20011 were higher in patients with CML in comparison with those of healthy individuals. It is concluded that positive association may exist between certain HLA-DPB1 alleles and CML.
View Article and Find Full Text PDFAssociation of HLA-DPB1 gene with endometriosis in women of Guangdong Province in China.
Di Yi Jun Yi Da Xue Xue Bao
May 2002
Objective: To analyze the hereditary susceptibility in patients with endometriosis by way of genotyping of HLA-DPB1 alleles.
Methods: The allelic types of HLA-DPB1 were detected by sequence-based typing (SBT) in 38 patients with endometriosis and 36 healthy women as the control.
Result: Significant differences in the frequency of HLA-DRB1 allele was not observed between endometriotic patients and normal subjects.