Publications by authors named "Ze-feng Lai"
Article Synopsis
- ACP6 is a mitochondrial enzyme that has been linked to lipid metabolism, but its role in human cancers, specifically hepatocellular carcinoma (HCC), was previously unknown.
- Research revealed that ACP6 is overexpressed in HCC, correlating with clinical progression and poorer survival rates among patients, while its expression also showed associations with various immune cells.
- In experiments, knocking down ACP6 in HCC cells reduced their proliferation and migration, suggesting that ACP6 could serve as a potential clinical biomarker and target for HCC treatment.
Hepatocellular carcinoma (HCC) is a leading cause of mortality in cancer patients, but the association between miR-125b-2-3p and the onset and prognosis of HCC has not been reported in previous studies; thus, the clinicopathological implications of miR-125b-2-3p in HCC require elaboration. To examine the expression of miR-125b-2-3p in HCC, both in-house RT-qPCR and public datasets were used to calculate the standard mean difference (SMD) and the summary receiver operating characteristic (sROC). MiR-125b-2-3p was markedly lower in HCC than in non-tumor tissue as assessed by the in-house RT-qPCR which was confirmed by the integrative analysis showing the SMD being -0.
View Article and Find Full Text PDFBackground: Hepatocellular carcinoma (HCC) remains one of the most common cancers worldwide and tends to be detected at an advanced stage. More effective biomarkers for HCC screening and prognosis assessment are needed and the mechanisms of HCC require further exploration. The role of MAOA in HCC has not been intensively investigated.
View Article and Find Full Text PDFNitidine chloride (NC) has reported tumor suppressive activities for various human cancers, including hepatocellular carcinoma (HCC). Nevertheless, the pharmacological mechanism of NC on HCC has not previously been elucidated. SMMC7721 HCC cell lines, before and after the treatment of NC, were injected into nude mice for a subcutaneous tumor xenograft model.
View Article and Find Full Text PDFIntroduction: MIR22HG has a reported involvement in the tumorigenesis of a variety of cancers, including hepatocellular carcinoma (HCC). However, the exact molecular mechanism of in HCC has not been clarified.
Methods: In the present study, we integrated data from in-house RT-qPCR, RNA-sequencing, microarray, and literature studies to conduct a comprehensive evaluation of the clinico-pathological and prognostic significance of in an extremely large group of HCC samples.
Nitidine chloride (NC) has been demonstrated to have an anticancer effect in hepatocellular carcinoma (HCC). However, the mechanism of action of NC against HCC remains largely unclear. In this study, three pairs of NC-treated and NC-untreated HCC xenograft tumour tissues were collected for circRNA sequencing analysis.
View Article and Find Full Text PDFArticle Synopsis
- Malignant cancer is the leading cause of death globally, with lung, liver, intestinal, and gastric cancers contributing significantly to this mortality.
- Although chemotherapy is effective, it often comes with severe side effects, while herbal medicines provide a more natural alternative with fewer adverse reactions but face challenges in targeted delivery.
- Single-walled carbon nanotubes (SWNTs) can enhance the efficacy of Chinese anticancer medicines by improving drug targeting and stability, leading to better therapeutic outcomes through various administration methods.