Publications by authors named "Ze-Tao Liao"
Article Synopsis
- Juvenile-onset ankylosing spondylitis (JAS) refers to patients whose symptoms begin before age 16, and it tends to have worse functional outcomes and early bone metabolism issues compared to adult-onset cases.
- A study measured inflammatory and bone metabolic markers (MMP-3, sRANKL, OPG) in JAS patients, finding significantly higher levels of MMP-3 and sRANKL, while OPG levels were only slightly elevated compared to healthy controls.
- The research indicated that MMP-3 levels correlated positively with disease activity (BASDAI) and function (BASFI), while sRANKL levels were linked to MMP-3 and inversely
Article Synopsis
- Ankylosing spondylitis (AS) is a common inflammatory disease with limited treatment options, and this study investigates the impact of the alkaloid sinomenine (SIN) on patients' peripheral blood mononuclear cells (PBMCs).* -
- The study involved 30 AS patients whose PBMCs were tested with and without SIN; results showed changes in the expression of various proteins linked to apoptosis and immune function.* -
- Eight proteins were identified as differentially expressed in SIN-treated PBMCs, providing insights into how SIN may work in treating AS.*
Background: Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation at the synovial membrane. Although great progress has been made recently in exploring the etiology and pathogenesis of RA, its molecular pathological mechanism remains to be further defined and it is still a great challenge in determining the diagnosis and in choosing the appropriate therapy in early patients. This study was performed to screen candidate RA-associated serum proteins by comparative proteomics to provide research clues to early diagnosis and treatment of RA.
View Article and Find Full Text PDFBackground: The role of B-cell remains an enigma in the pathogenesis of ankylosing spondylitis (AS). This study aimed to investigate the distributions of B-cells and subsets in peripheral blood of AS patients and observe their changes in etanercept-treated AS patents.
Methods: We detected the proportions of CD19(+) B-cell, naive B-cell (CD19(+)CD27-), memory B-cell (CD19(+)CD27dim) and plasmablast (CD19(+)CD27high) in peripheral blood of 66 patients with AS (39 at active stage, 27 at stable stage; 35 patients with peripheral joint involvement, 31 patients with axial involvement alone), 30 patients with rheumatoid arthritis (RA) and 30 healthy volunteers using flow cytometry.
[Screening and verification of questionnaire indexes for epidemiological studies on spondyloarthropathy].
Zhonghua Liu Xing Bing Xue Za Zhi
May 2007
Objective: To screen the parameters of questionnaire in prevalence survey of spondyloarthropathy (SpA) in China, and to evaluate the value and feasibility of questionnaire used in prevalence survey.
Methods: A questionnaire study on SpA with 12 questions involved was performed which came from a epidemiological survey on SpA in Brittany, France.
Results: (1) We found difference on the sensitivity and specificity of some indexes in the questionnaires between the French study and the one developed by ourselves.