Effect of , and supernatants on serotonin transporter expression in cells and tissues.

Background: (), (), and () are probiotics that are widely used in the clinical treatment of irritable bowel syndrome (IBS). Whether the supernatants of these three probiotics can improve gastrointestinal sensation and movement by regulating the serotonin transporter (SERT) expression needs to be clarified.

Aim: To investigate whether , and supernatants can upregulate SERT expression and .

Effect of GG supernatant on serotonin transporter expression in rats with post-infectious irritable bowel syndrome.

Aim: To evaluate the effect of GG supernatant (LGG-s) on the expression of serotonin transporter (SERT) in rats with post-infectious irritable bowel syndrome (PI-IBS).

Methods: 81-176 (10 CFU/mL) was used to induce intestinal infection to develop a PI-IBS model. After evaluation of the post-infectious phase by biochemical tests, DNA agarose gel electrophoresis, abdominal withdrawal reflex (AWR) test, and the intestinal motility test, four PI-IBS groups received different concentrations of LGG-s for 4 wk.