Publications by authors named "Ze-Kun Wang"

Acne is a chronic inflammatory disease of pilosebaceous unit, which can be aggravated by hyperkeratosis of the pilosebaceous unit, excessive secretion of sebum and the proliferation of Propionibacterium acnes (P. acnes). Traditional drug treatment methods commonly exhibit drawbacks, including bacterial resistance and poor transdermal permeability, resulting in suboptimal efficacy and recurrent infections.

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Background: Hemorrhagic fever with renal syndrome (HFRS) is a natural epidemic disease that can be caused by the Hantaan virus (HTNV). Malaria is caused by plasmodium and can be transmitted by a mosquito bite. The similar manifestations shared by these disorders pose a challenge for clinicians in differential diagnosis, in particular, coupled with a false-positive serological test.

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There has been an upward trend in the incidence of glioma, with high recurrence and high mortality. The beta subunits of the 20S proteasome are encoded by the proteasome beta (PSMB) genes and may affect the proteasome's function in glioma, assembly and inhibitor binding. This study attempted to reveal the function of the proliferation and invasion of glioma cells, which is affected by proteasome 20S subunit beta 2 (PSMB2).

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Article Synopsis
  • Coinfection with multiple pathogens, particularly the co-infection of SARS-CoV2 and Hantaan virus (HTNV), is a significant concern for global public health, but instances are underreported.
  • This study highlights three cases involving HTNV and SARS-CoV2, revealing not only typical symptoms from each virus but also unusual symptoms like lung exudation and kidney enlargement, which diverge from classic viral pneumonia presentations.
  • The successful recovery of these patients through antiviral treatments and supportive care underscores the need for greater awareness and research on the effects of such coinfections on patient outcomes and public health.
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  • The study utilized UHPLC-Q-TOF-MS/MS to perform a qualitative analysis of the chemical constituents in Schizonepetae Spica.
  • An Agilent poroshell 120 SB-C_(18) column was used for gradient elution with a specific mobile phase and set parameters for optimal results.
  • A total of 97 compounds were identified, which included various categories like flavonoids, phenolic acids, and terpenoids, showcasing the method's ability to quickly and accurately identify the chemical components of the plant.
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 Primary frontal sinus malignancies (FSMs) are the rarest sinonasal cancers. This study aimed to determine clinicopathologic characteristics of primary FSMs and provide long-term survival outcomes.  This study is a retrospective review.

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Singlet oxygen (O) has received considerable research attention in photodynamic therapy (PDT) due to its cytotoxic solid features. However, the inherent hypoxic state of the tumor microenvironment (TME) leads to the meager O quantum yield of inorganic PDT reagents, and their application remains elusive. We developed a novel strategy to fabricate active photosynthetic bacteria/photosensitizer/photothermal agent hybrids for photosynthetic tumor oxygenation and PDT and PTT tumor therapy under different laser irradiation sources.

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Background: Foreign imported patients and within-household transmission have been the focus and difficulty of coronavirus disease 2019 (COVID-19) prevention and control, which has also posed challenges to border areas' management. However, household transmission caused by foreign imported cases has not been reported in China's border areas. This study aimed to reveal a clear family clustering transmission chain of COVID-19 caused by contact with Myanmar refugees along the China-Myanmar border during an outbreak in October to November 2021.

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  • Excess bilirubin buildup in patients with acute liver failure can lead to severe health issues like kernicterus and hepatic coma, making its removal critical.
  • The authors developed four supramolecular organic framework microcrystals that showed excellent stability and rapid adsorption of bilirubin, achieving a capacity of 609.1 mg/g within just 20 minutes.
  • Their modified microcrystals, combined with poly(ether sulfone), effectively brought bilirubin levels in human plasma down to normal through a hemoperfusion process, suggesting a promising new avenue for treatment.
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  • * A newly developed biocompatible porous organic polymer (POP) can effectively suppress skin phototoxicity from commonly used photodynamic agents without compromising their therapeutic effectiveness.
  • * In vivo studies demonstrate that POP reduces the presence of these agents in the skin of mice, offering a promising solution for managing post-PDT side effects.
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Cardiovascular disease (CVD) is a major cause of death worldwide. Research findings indicate that periodontal infection is an independent risk factor for CVD. Periodontal pathogens can cause cardiovascular diseases through various pathways, including direct invasion, induction of platelet activation and agglutination, immune inflammatory response, bacteremia, and oxidative stress.

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  • Aldoxorubicin (AlDox), a prodrug of doxorubicin (Dox), has lower cardiotoxicity but lacks overall survival benefits in patients, according to Phase I-III clinical studies.! -
  • Researchers created two polymeric prodrugs of Dox by linking AlDox to three-dimensional supramolecular organic frameworks (SOFs), which enhance drug delivery and effectiveness in tumor cells.! -
  • Experiments show that these SOF-linked prodrugs significantly boost antitumor efficacy without causing cardiotoxicity, making them a promising strategy for improving prodrug design in cancer treatment.!
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  • Photodynamic therapy (PDT) has been effective for cancer and skin diseases for over 20 years, but photodynamic agents (PDAs) can cause significant skin phototoxicity, requiring patients to avoid sunlight for extended periods, with no effective solutions until now.
  • Researchers have developed three-dimensional diamondoid supramolecular organic frameworks (SOFs) that can suppress the skin phototoxicity of commonly used PDAs like Photofrin, HiPorfin, and Talaporfin by using an adsorption and retention mechanism.
  • Experiments show that SOFs have strong interactions with PDAs, maintaining PDT efficacy while significantly reducing skin sensitivity to sunlight, thus offering a safer approach for patients undergoing PDT.
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Article Synopsis
  • - Water-soluble supramolecular-organic frameworks (SOFs) and temoporfin (THPC) create uniform self-assembled nanoparticles that enhance oxygen generation efficiency by minimizing aggregation-related issues.
  • - These self-assembled nanoparticles are biocompatible, making them safe for use in biological applications.
  • - In tests, the nanoparticles exhibit increased effectiveness in killing four types of human cancer cells and significantly suppress tumor growth in a mouse model.
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Chemotherapy is one of the main ways to treat breast cancer clinically. However, the multidrug resistance to anti-tumor drugs limits their clinical use. To overcome these drawbacks, development of drug delivery systems (DDSs) has attracted more and more attention in cancer therapy.

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Chemotherapy is one of the main ways to treat breast cancer clinically. However, the multidrug resistance to anti-tumor drugs limits their clinical use. To overcome these drawbacks, the development of drug delivery systems (DDSs) has attracted more and more attention in cancer therapy.

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Accurate control of the layer number of orderly stacked 2D polymers has been an unsettled challenge in self-assembly. Herein we describe the fabrication of a bilayer 2D supramolecular organic framework from a monolayer 2D supramolecular organic framework in water by utilizing the cooperative coordination of a rod-like bipyridine ligands to zinc porphyrin subunits of the monolayer network. The monolayer supramolecular framework is prepared from the co-assembly of an octacationic zinc porphyrin monomer and cucurbit[8]uril (CB[8]) in water through CB[8]-encapsulation-promoted dimerization of 4-phenylpyridiunium subunits that the zinc porphyrin monomer bear.

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Two organic cages have been prepared in situ in water through the 2 + 3 hydrazone coupling of two pyridinium-derived trialdehydes and oxalohydrazide. The highly water-soluble cages encapsulate and solubilize linear neutral molecules. Such encapsulation has been applied for the promotion of both two- or three-component hydrazone condensation in water.

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Porous organic frameworks (POFs) with predesigned structures and tunable porosities have been widely studied in adsorption and heterogeneous catalysis. Introducing ionic structure into the framework endows POFs with new functionalities that may extend their applications. Here, we report new applications for a guanidinium-based ionic POF (IPOF-Cl) in palladium scavenging and heterogeneous catalysis.

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Objective: The relationship between vitamin intake and the occurrence of cancer is controversial. The aim of this study was to examine the genetic associations between vitamins D, E, and B and five cancers (i.e.

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The self-assembly of a diamondoid woven supramolecular metal-organic framework wSMOF-1 has been achieved from intertwined [Ru(tpy) ] (tpy=2,2',6',2''-terpyridine) complex M1 and cucurbit[8]uril (CB[8]) in water, where the intermolecular dimers formed by the appended aromatic arms of M1 are encapsulated in CB[8]. wSMOF-1 exhibits ordered pore periodicity in both water and the solid state, as confirmed by a combination of H NMR spectroscopy, UV-vis absorption, isothermal titration calorimetry, dynamic light scattering, small angle X-ray scattering and selected area electron diffraction experiments. The woven framework has a pore aperture of 2.

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Four water-soluble hydrazone-based three-dimensional (3D) flexible organic frameworks have been synthesized from a semirigid tetracationic tetraaldehyde and four flexible dihydrazides. H NMR spectroscopy indicated the quantitative formation of in DO, while dynamic light scattering experiments revealed that, depending on the concentration, these porous frameworks display hydrodynamic diameters ranging from 50 to 120 nm. The porosity of the frameworks is confirmed by ethanol vapor adsorption experiments of the solid samples as well as the high loading capacity for a 2.

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Interlinking discrete supertetrahedral chalcogenolate clusters with conjugated bipyridine linkers form a one-dimensional coordination polymer, [CdAg(SPh)(DMF)(HO)(bpe)] (), displaying a broader visible-light absorption and a narrower band gap than those of the discrete cluster. More importantly, the coordination polymer demonstrates enhanced activity and stability for the photocatalytic degradation of organic dye in water.

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