Publications by authors named "Ze-Hao Zeng"
Article Synopsis
- Methamphetamine is a highly addictive drug that alters the brain's reward system, specifically affecting the nucleus accumbens (NAc), but the role of the protein LASP1 in this process is not fully understood.
- In experiments with male mice, researchers found that repeated meth exposure increased LASP1 levels in the NAc, and manipulating LASP1 expression changed drug-seeking behavior and the levels of certain synapse-related proteins.
- The study suggests that LASP1 is a key player in how methamphetamine influences addiction and offers potential avenues for developing treatments for meth addiction.
Autism spectrum disorder (ASD) is neurodevelopmental disorder with a high incidence rate, characterized by social deficits and repetitive behaviors. There is currently no effective management available to treat the core symptoms of ASD; however, oxidative stress has been implicated in its pathogenesis. Edaravone (EDA), a free-radical scavenger, is used to treat amyotrophic lateral sclerosis (ALS) and acute ischemic stroke (AIS).
View Article and Find Full Text PDFOverweight induced by high-fat diet (HFD) represents one of the major health concerns in modern societies, which can cause lasting peripheral and central metabolic disorders in all age groups. Specifically, childhood obesity could lead to life-long impact on brain development and functioning. On the other hand, environmental enrichment (EE) has been demonstrated to be beneficial for learning and memory.
View Article and Find Full Text PDF