Publications by authors named "Ze-Han Wang"
Sulfonated Azocalix[4]arene: A Universal and Effective Taste-Masking Agent.
ACS Appl Mater Interfaces
October 2024
Many active pharmaceutical ingredients have a specific bitter taste. To enhance patient compliance and treatment efficacy, taste-masking agents are crucial in oral drug formulations. Confronting numerous bitter drug molecules with varied structures, the pharmaceutical field strives to explore and develop universal and effective masking approaches.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers created a novel drug delivery system using a compound called p-phosphonatocalix[4]arene tetradodecyl ether (PC4A12C) that specifically targets bones to improve treatment efficacy with icariin (ICA), a drug with strong bone-forming properties.
- * In lab studies, the new ICA-loaded PC4A12C system showed better results in promoting bone cell growth and mineralization, and in mouse models, it significantly improved bone density and osteogenic activity compared
The identification and detection of pesticides is crucial to protecting both the environment and human health. However, it can be challenging to conveniently and rapidly differentiate between different types of pesticides. We developed a supramolecular fluorescent sensor array, in which calixarenes with broad-spectrum encapsulation capacity served as recognition receptors.
View Article and Find Full Text PDFThe complexity, heterogeneity, and drug resistance of diseases necessitate a shift in therapeutic paradigms from monotherapy to combination therapy, which could augment treatment efficiency. Effective treatment of advanced osteoarthritis (OA) requires addressing three key factors contributing to its deterioration: chronic joint inflammation, lubrication dysfunction, and cartilage-tissue degradation. Herein, we present a supramolecular nanomedicine of multifunctionality via molecular recognition and self-assembly.
View Article and Find Full Text PDFThe complexity and progressive nature of diseases require the exploitation of multifunctional materials. However, introducing a function inevitably increases the complexity of materials, which complicates preparation and decreases reproducibility. Herein, we report a supramolecular integration of multifunctional nanomaterials based on mannose-modified azocalix[4]arene (ManAC4A) and ginsenoside Rb1 (Rb1), which showed advances of simplicity and reproducibility.
View Article and Find Full Text PDFArticle Synopsis
- Pancreatic cancer has a very poor prognosis, primarily due to tumor hypoxia, which is a lack of oxygen in the tumor environment.
- Targeting tumor hypoxia is seen as a promising therapeutic strategy, but past efforts have not achieved clinical success.
- A new compound, NMP-BE@SAC5A, has been developed that effectively targets hypoxic pancreatic cancer cells and has shown significant tumor growth suppression in animal models without causing systemic toxicity.
Supramolecular Radiosensitizer Based on Hypoxia-Responsive Macrocycle.
Adv Sci (Weinh)
February 2022
Article Synopsis
- * A new supramolecular approach utilizes a special macrocycle to enhance the effectiveness of a radiosensitizer called AQ4N, improving drug delivery to tumors in low-oxygen environments.
- * This innovative strategy shows a high sensitizer enhancement ratio and has the potential for wider application with other radiosensitizing drugs, making it promising for future clinical use.