Publications by authors named "Ze-En Li"

This experiment aimed to investigate the in vitro antimicrobial activity of danofloxacin against Escherichia coli (E. coli) isolated from pigeons, as well as the pharmacokinetics of danofloxacin in pigeons following oral (PO), intramuscular (IM), and intravenous (IV) administration. The minimum inhibitory concentration (MIC) of danofloxacin was first determined for 38 clinical E.

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The current study aimed to investigate the pharmacokinetics of bromhexine hydrochloride in broilers after single intravenous (IV) and oral (PO) administration at 2.5 mg/kg body weight (BW). The trial adopted a randomized, parallel-controlled design, where 20 twelve-wk-old broilers were randomly assigned to either the PO or IV group.

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  • * Each breed received a single dose of gamithromycin, and tissue samples were collected at several intervals to measure drug concentration using advanced chromatography techniques.
  • * Results showed that yellow-feathered broilers retained higher levels of gamithromycin for longer periods, while the elimination rates varied by tissue type, indicating differences that may relate to tissue pigmentation.
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This study aimed to investigate the in vitro antibacterial activity of danofloxacin against Escherichia coli isolated from Gushi chickens, as well as the tissue distribution and residue depletion of danofloxacin in Gushi chickens following multiple oral administration. A total of 42 clinical E. coli strains were isolated from the cloaca of locally farmed Gushi chickens between August and October 2023.

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  • This study examines how chitooligosaccharide (COS) and florfenicol (FLO) work together to inhibit Escherichia coli in lab tests and their interactions in healthy chickens.
  • The research includes determining the minimum concentrations needed to inhibit bacteria and investigating the pharmacokinetics of these compounds after administering them to chickens in different treatment groups.
  • Results indicate that COS enhances the effectiveness of FLO against E. coli and alters its pharmacokinetics, particularly increasing the elimination half-life of florfenicol when combined with the different COS types.
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This study aimed to examine the depletion of tilmicosin residues in Gushi chickens following the administration at a concentration of 75 mg/L in their drinking water for three consecutive days. Plasma, liver, kidney, lung, muscle, and skin + fat samples were collected from 6 chickens at 6 h, 1, 3, 5, and 7 days after the treatment. Tilmicosin concentrations in the samples were determined using a high-performance liquid chromatography (HPLC) method.

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This study aimed to determine the pharmacokinetics of danofloxacin in Gushi chickens after a single oral (PO) and intravenous (IV) dose at 5 mg/kg body weight (BW). Thirty-two Gushi chickens, aged 20 weeks, were selected and divided into two groups at random, with each group consisting of 16 chickens, evenly distributed between males and females. Following danofloxacin administration, blood samples were taken at predetermined time intervals and the plasma was separated.

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  • - This study explored how difloxacin, a drug, is processed in crucian carp after a single oral dose of 20 mg/kg body weight, using plasma sampling and high-performance liquid chromatography (HPLC) for analysis.
  • - A population model was created using a nonlinear mixed effects approach, which showed that only covariance, not body weight, influenced the drug's pharmacokinetic parameters like absorption rate, volume of distribution, and clearance.
  • - Results indicated that the current dosing may not be sufficient to combat certain pathogens, suggesting further research on pathogen MIC values and pharmacodynamics to find an effective treatment dose for infections in crucian carp.
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This study aimed to determine the pharmacokinetics of meloxicam in pigeons. Twenty-four 7-wk-old meat pigeons (Columba livia) were randomly divided into 3 groups (PO, IM, and IV) and given a single dose of 1 mg/kg body weight of meloxicam. Plasma samples were taken at predetermined times, which were then analyzed using a validated high-performance liquid chromatography (HPLC) method and subjected to noncompartmental analysis using Phoenix software.

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Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) commonly used in an extra-label manner in commercial laying hens for the treatment of foot lesions, which are a common issue in this species. The present study aimed to determine the depletion profiles of meloxicam in eggs with multiple oral administration under 2 different dosing regimens and to further recommend reasonable withdrawal intervals (WDIs). Meloxicam (1 mg/kg) was administered orally to laying hens under 2 dosing schedules: 10 doses at 24-h intervals and 15 doses at 12-h intervals.

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Withdrawal periods for diclazuril in broilers have traditionally been determined through regression analysis. However, over the last two decades, the physiologically based pharmacokinetic (PBPK) model has gained prominence as a predictive tool for veterinary drug residues, which offers an alternative method for establishing appropriate withdrawal periods for veterinary drugs. In this current study, a flow-limited PBPK model was developed to predict diclazuril concentrations in broilers following long-duration administration via medicated feed and water.

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  • This study investigated how danofloxacin is processed in Yellow River carp after a single oral dose of 10 mg/kg body weight, focusing on its population pharmacokinetics.
  • Researchers collected plasma samples at various time points to measure drug concentrations using HPLC, finding that danofloxacin could be detected for up to 144 hours post-administration.
  • The population pharmacokinetic model developed highlighted the variability in absorption, distribution, and clearance, suggesting that the current dosing effectively inhibits certain pathogens, but further research is needed to confirm its antibacterial efficacy.
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In the present study, terminal-restriction fragment length polymorphism (T-RFLP) technique was applied to assess the diversity and tissue distribution of the fungal endophyte communities of Alpinia officinarum collected from Longtang town in Xuwen county, Guangdong province, China, at which the pharmacological effect of the medicine plant is traditional considered to be the significantly higher than that in any other growth areas in China. A total of 28 distinct Terminal-Restriction Fragment (T-RFs) were detected with HhaI Mono-digestion targeted amplified fungal nuclear ribosomal internal transcribed spacer region sequences (rDNA ITS) from the root, rhizome, stem, and leaf internal tissues of A. officinarum plant, indicating that at least 28 distinct fungal species were able to colonize the internal tissue of the host plant.

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Objective: To study the preventive effect of Shenfu Injection (SI) in different dosage on occurrence of heart failure in patients of acute myocardial infarction (MI) with elevated ST segment.

Methods: Ninety-seven patients of MI were divided into 3 groups, all were treated with conventional therapy, but to the SI treated groups, intravenous injection of low (0.3 ml/kg) or high dose (0.

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