Electroacupuncture Inhibits Atherosclerosis through Regulating Intestinal Flora and Host Metabolites in Rabbit.

Methods: In this study, general rabbit conditions, vascular histology, metabolites, and intestinal flora structures were analyzed. Integrated analysis of metabolomics and 16S rRNA sequencing were performed. All the rabbits were randomly divided into four groups.

[Systematic review on the animal experiments of electroacupuncture for hyperlipidemia combined with atherosclerosis].

Objective: To systematically review the effectiveness and safety of electroacupuncture (EA) on hyperlipidemia combined with atherosclerosis in animal experiments.

Methods: The relevant animal experiments of EA treatment for hyperlipidemia combined with atherosclerosis were retrieved from the CNKI, WANFANG, VIP, CBM, PubMed, Embase and the Cochrane Library up to March 19, 2018 since the establishment of databases. Two researchers in the project team screened the literature and extracted the information such as experiment objects, experiment steps and experiment results separately.

[Effects of electroacupuncture on CYP7A1 expression in liver of rabbits with atherosclerosis].

Objective: To observe the effects of electroacupuncture (EA) at "Neiguan" (PC 6), "Guanyuan" (CV 4) and "Zusanli" (ST 36) on CYP7A1 expression in liver of rabbits with atherosclerosis (AS), and to explore the mechanism of acupuncture for prevention and treatment of atherosclerosis.

Methods: A total of 26 male rabbits were adaptively fed for 1 week in different cages. Seven rabbits were randomly divided into a blank group, and the remaining 19 rabbits were divided into a model group.

[Effect of Electroacupuncture on Expression of Scavenger Receptor A I in Peritoneal Macrophages of Atherosclerotic Rabbits].

Objective: To observe the effect of electroacupuncture (EA) on the expression of scavenger receptor A I (SR-A I) protein and mRNA in peritoneal macrophages of atherosclerosis (AS) rabbits.

Methods: A total of 26 New Zealand rabbits were used in the present study, among them, 7 were randomly selected to constitute a blank control group, and the rest 19 rabbits were fed with high-fat diet combined with carotid artery balloon injury for establishing AS model. Eight weeks after high-fat forage feeding, one high-fat fed rabbit and one normal rabbit were randomly selected for verifying the success of modeling.

[Effects of Electroacupuncture on Expression of Myocardial Chloride Channel-2 and CLCA Proteins in Mice with Acute Myocardial Ischemia].

Objective: To observe the influence of electroacupuncture stimulation (EA) of "Neiguan" (PC 6)/"Lieque" (LU 7) on ST segment of electrocardiogram (ECG) and the expression of myocardiac chloride channel (CLC)-2 and calcium (Ca)-activated chloride channel accessory (CLCA) proteins in acute myocardial ischemia (AMI) mice, so as to explore its mechanisms underlying improvement of AMI.

Methods: Thirty ASIC 3 knock out mice were randomly divided into control, AMI model, EA-Neiguan (PC 6), EA-Lieque (LU 7) and EA-non-acupoint groups. The AMI model was induced by multiple subcuta-neous injection of isoprenaline (ISO, 0.

[Effects of acupuncture on distribution taxis of paclitaxel in mice with lung cancer].

Objective: To observe the effects of acupuncture at "Feishu" (BL 13) and "Lingtai" (GV 10) on distribution taxis of paclitaxel in mice with lung cancer to discuss targeted relationship between acupoints and corresponding viscera.

Methods: According to randomized digital table, 315 SPF-grade BALB/C female mice were divided into 7 groups: blank group (group A), model group (group B), medication group (group C), acupuncture at non-acupoint group (group D), acupuncture at Feishu group (group E), acupuncture at Lingtai group (group F) and acupuncture at Feishu and Lingtai group (group G), 45 mice in each one. Except the blank group, the remaining groups were treated with N-nitroso-tris-chloroethyl urea (NTCU) to establish the model of squamous-cell carcinoma.

The impacts of along-channel acupuncture on the protein expressions of the chloride channel of the rats with myocardial ischemia.

Recent evidence suggests that chloride (CL(-)) channels are involved in myocardial ischemia. In this study, the impact of acupuncture on the protein expressions of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and CLC-2 CL(-) channel of the rats with myocardial ischemia were tested and its mechanism was explored. The rats for experiment were distributed randomly into 5 groups: blank control group, modeling control group, Neiguan (PC-6) treatment group, Lieque (LU-7) control group, and Non-acupoint control group.

Effects of acupuncture at Taixi acupoint (KI3) on kidney proteome.

This research explored and identified the protein composition of rat kidneys after acupuncture at the Taixi acupoint (KI3). Twelve adult male Wistar rats were randomly divided into a control group (n = 6) and an acupuncture group (n = 6). Rats in the acupuncture group received electroacupuncture on the bilateral KI3 for seven days.

[Effect of acupuncture combined with intraperitoneal injection of paclitaxel on apoptosis in Lewis mice with lung carcinoma].

Objective: To observe the effect of acupuncture in combination with Paclitaxel on apoptosis in Lewis lung carcinoma mice so as to investigate their anti-cancer mechanism.

Methods: A total of 48 mice with inoculated Lewis lung carcinoma (LLC) were randomized into model, acupuncture, medication and acupuncture + medication groups, with 12 cases in each group. LLC model was established by subcutaneously incubating LLC cells into the left hindlimb of the C17 BL/6 mice.