Publications by authors named "Ze Rui Wang"
Article Synopsis
- The study examined genetic diversity and drug resistance in HIV patients in Beijing, focusing on both pretreatment and acquired drug resistance.
- Analysis was performed on patient data from a hospital between 2013 and 2020, using PCR to assess drug resistance mutations, with findings indicating notable prevalence rates of 12.9% for pretreatment and 27.8% for acquired drug resistance.
- Key mutations linked to common treatments were found, and factors like specific genotypes and high viral loads increased the risk of drug resistance, highlighting the importance of regular drug resistance screenings in HIV treatment.
Article Synopsis
- Antiretroviral therapy (ART) effectively lowers viral loads in HIV-infected individuals, but some still experience poor immune recovery; researchers studied the immune cell profiles to understand this phenomenon better.
- The study analyzed immune cells from different groups (treatment-naïve, immunological non-responders, immunological responders, and healthy controls) using mass cytometry and identified correlations between immune cell types and various health indicators like viral RNA and CD4 counts.
- Key findings included observed immune cell activation, exhaustion, and changes in specific immune cell subsets among treatment-naïve individuals, indicating a relationship between immune cell composition and the success of ART, which may help tackle incomplete immune recovery in certain patients.
Article Synopsis
- The study aimed to find biomarkers in plasma that can help predict which severe COVID-19 patients will respond positively to mesenchymal stem cell (MSC) therapy.
- A total of 58 patients were assessed, with 35 classified as responders based on significant improvement in lung consolidation after MSC treatment and 23 as non-responders.
- The analysis identified 4 key proteins (DDX55, AGRG6, PICAL, and CTRB1) that reliably predicted treatment success, suggesting that these biomarkers should inform clinical decisions regarding MSC therapy for severe COVID-19.
Article Synopsis
- The intestinal epithelial barrier is crucial in the progression of HIV disease, but its damage in different patient groups is not well understood.
- A study compared intestinal damage and related markers among immunological responders (IRs), immunological non-responders (INRs), and healthy controls.
- It found that both IRs and INRs had persistent intestinal damage, with INRs showing more severe damage, which was linked to higher HIV DNA levels and lower CD4 T cell counts.
Article Synopsis
- Studies on gut immune balance in HIV patients are limited; this research focuses on intestinal samples from different groups: immunological nonresponders (INRs), immunological responders (IRs), and HIV-negative controls.
- Key findings reveal that INRs have reduced Th17 and increased Treg cell counts compared to IRs, highlighting a significant difference in the Th17/Treg ratio, which is linked to markers of intestinal health like ZO-1 and I-FABP.
- The Th17/Treg ratio correlates positively with CD4 T cell counts and negatively with intestinal HIV DNA, suggesting that an imbalance in these cells indicates incomplete immune recovery and is associated with intestinal damage in HIV-infected individuals.
Article Synopsis
- The study aimed to assess the long-term safety and effectiveness of human mesenchymal stem cell (MSC) treatment in patients with severe COVID-19, following a previous clinical trial.
- Out of 100 patients, those receiving MSC treatment showed marginally better walking distance and overall health scores compared to the placebo group after 18 months, but no significant differences in lung imaging or antibody levels at 18 and 24 months.
- While MSC treatment proved to be safe for the patients over two years, its effectiveness did not show sustained improvement by the end of the follow-up period.
Stem Cell Therapies for Chronic Liver Diseases: Progress and Challenges.
Stem Cells Transl Med
September 2022
Article Synopsis
- Chronic liver diseases are a major global health concern, necessitating new treatment options alongside liver transplants.
- Recent studies suggest that cell-based therapies could help improve liver function by addressing tissue damage and modulating the immune response.
- This review highlights the progress and challenges of various cell therapies in clinical and animal studies, specifically focusing on mesenchymal stem cells and critical factors like dosage and transfusion methods.
Article Synopsis
- SHP-1, a protein that regulates inflammation, is significantly lower in hepatocellular carcinoma (HCC) tissues compared to noncancerous ones and is linked to poorer patient survival.
- Overexpressing SHP-1 in HCC cells decreases their growth and invasive abilities, while reducing SHP-1 levels leads to worse cancer traits.
- SHP-1 also inhibits certain cancer-related signaling pathways and shows promise as both a prognostic biomarker and therapeutic target for HCC.
Article Synopsis
- Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA-M2BP) is identified as a novel glycobiomarker that helps evaluate liver function and predict prognosis in patients with liver cirrhosis (LC).
- A study involving 197 LC patients found WFA-M2BP levels increased with the severity of liver disease, particularly among those with hepatitis B virus (HBV) infection, showing strong correlation with established liver assessment scores like Child-Pugh and MELD.
- The findings support WFA-M2BP as an independent predictor for clinical complications and mortality, suggesting its potential inclusion in the monitoring of cirrhotic patients, particularly those affected by HBV.
Article Synopsis
- Emerging infectious diseases pose sudden and unexpected threats to global health, making timely information and rapid response crucial for management.
- A database was created in mainland China to support this response, utilizing geo-coding, Google Maps, and 3G networks for real-time data collection and analysis.
- The Decision Support System for Infectious Disease Emergencies (DSSRIDE) enhances field investigations by offering tools like real-time communication, customized questionnaires, and access to professional resources, facilitating better handling of disease outbreaks.