Food substances alter gut resistome: Mechanisms, health impacts, and food components.

Antibiotics are effective in treating bacterial infections, but their widespread use has spurred antibiotic resistance, which is linked closely with human disease. While dietary components are known to influence the gut microbiome, specific effects on the gut resistome-the collection of antibiotic-resistant genes in the gut-remain underexplored. This review outlines the mechanisms of antibiotic action and the development of resistance, emphasizing the connection between the gut resistome and human diseases such as metabolic disorders, cardiovascular disease, liver disease, and nervous system disorders.

Association between the EHBP1 SNPs and dyslipidemia in the end-stage renal disease patients with dialysis in Chinese Han population.

Background: Lipid metabolism is influenced by mutations in the EH domain binding protein 1 gene (EHBP1). This study investigated the link between the EHBP1 single-nucleotide polymorphisms (SNPs) and dyslipidemia risks in maintenance dialysis patients with end-stage renal disease in Chinese Han population.

Methods: A total of 539 patients were divided into dyslipidemia (379) and control (160) groups.

Lower regional urbanicity and socioeconomic status attenuate associations of green spaces with hypertension and diabetes mellitus: a national representative cross-sectional study in China.

Background: High blood pressure (HBP) and diabetes mellitus (DM) are two of the most prevalent cardiometabolic disorders globally, especially among individuals with lower socio-economic status (SES). Studies have linked residential greenness to decreased risks of HBP and DM. However, there has been limited evidence on whether SES may modify the associations of residential greenness with HBP and DM.

Associations between heat waves and chronic kidney disease in China: The modifying role of land cover.

The increasing frequency of heat waves under the global urbanization and climate change background poses elevating risks of chronic kidney disease (CKD). Nevertheless, there has been no evidence on associations between long-term exposures to heat waves and CKD as well as the modifying effects of land cover patterns. Based on a national representative population-based survey on CKD covering 47,086 adults and high spatial resolution datasets on temperature and land cover data, we found that annual days of exposure to heat waves were associated with increased odds of CKD prevalence.

Ambient PM components and prevalence of chronic kidney disease: a nationwide cross-sectional survey in China.

Objectives: Chronic kidney disease (CKD) is a global public health concern, and accumulating evidence has indicated that air pollution increases the odds of CKD. However, a limited number of studies have examined the long-term effects of ambient fine particulate matter (PM) components on the risk of CKD among general population; thus, major knowledge gaps remain.

Methods: Using data from a nationwide representative cross-sectional survey in China and a validated PM composition dataset, we established generalized linear models to quantify the association between five major components of PM and CKD prevalence.

Regional urbanicity levels modify the association between ambient air pollution and prevalence of obesity: A nationwide cross-sectional survey.

Ambient air pollution exposure may increase the risk of obesity, but the population susceptibility associated with urbanicity has been insufficiently investigated. Based on a nationwide representative cross-sectional survey on 44,544 adults, high-resolution night light satellite remote sensing products, and multi-source ambient air pollution inversion data, the present study evaluated the associations of fine particulate matter (PM) and nitrogen dioxide (NO) concentrations with the prevalence of obesity and abdominal obesity. We further calculated the associations in regions with different urbanicity levels characterized by both administrative classification of urban/rural regions and night light index (NLI).

Construction of layered double hydroxide-modified silica integrated multilayer shell phase change capsule with flame retardancy and highly efficient thermoregulation performance.

Current energy problems have driven the development of thermal storage technology based on phase change materials (PCMs). However, the leakage and flammability of organic PCMs appeared as troublesome agendas that deserve attention. In this article, the strategy of constructing phase change capsules with paraffin wax (PW) core and multilayer shell was proposed aiming to address the above issues.

A Method of Evaluating Safe Operating Space: Focus on Geographic Regions, Income Levels and Developing Pathway.

Safe and Just Space (SJS) is a framework for determining the range where the use of natural resources within the Earth's carrying capacity can maintain human well-being. However, there has been no systematic monitoring and evaluation of their sustainability across time and space. Here we developed and applied a model and a sustainable development human safe operation space (SDHSOS) index to assess the sustainability capacity and development path of 149 countries from 2000 to 2018.

Ongoings in the apple watercore: First evidence from proteomic and metabolomic analysis.

The presence of watercored fruit with translucent mesocarp has attracted immense attention due to its unique morphology and taste, however, the metabolic reconstruction between watercored and non-watercored tissues remain elusive. Herein, the combined proteomic and metabolomic approach was carried out to characterize the protein abundance and metabolic profile in watercored apple. Results demonstrated that carbohydrate metabolism was prioritized enriched in watercored apple, including highly accumulated sucrose and sugar alcohols, and the increased level of transcription factor WHIRLY2 (WHY2), which is required in sugar reallocation.

Establishment of loop-mediated isothermal amplification for detection using a warmer pad as a heating source.

The study sought to establish a sensitive and specific on-site loop-mediated isothermal amplification (LAMP) for heated using a warmer pad. LAMP primers specific to the conserved gene were designed, and the LAMP reaction was optimized. The heating characteristics of the warmer pad were investigated.

Ambient ozone pollution and prevalence of chronic kidney disease: A nationwide study based on the China National survey of chronic kidney disease.

The health hazards of ambient ozone (O) pollution are receiving increasing attention worldwide. However, the evidence on the association between O and risks of chronic kidney disease (CKD) remains insufficient and inconsistent, particularly in developing countries where there is an absence of macroscopic investigations at a large population scale. Based on data from a representative nationwide cross-sectional CKD survey in 13 Chinese provinces and a high resolution O air pollution inversion dataset, generalized linear models were used to evaluate the associations of O concentration with prevalence of CKD.

Comparison of the Clinical Efficacy of Transforaminal Endoscopy and Microtubular Technology for the Treatment of Lumbar Dumbbell-Shaped Tumors.

Objective: To analyze differences in feasibility and efficacy between the paravertebral approach and microtubular tumorectomy (PAMT) or percutaneous transforaminal endoscopic tumorectomy (PTET) for the treatment of lumbar dumbbell-shaped tumors.

Methods: Clinical data of dumbbell-shaped lumbar tumors in patients treated with PAMT or PTET in our hospital between June 2015 and November 2020 were retrospectively analyzed. The gross total resection (GTR) rate, operation time, estimated blood loss, postoperative hospital stay (PHS), postoperative neurological function, and spinal stability were compared between the 2 surgical methods.

Bioactive peptides of plant origin: distribution, functionality, and evidence of benefits in food and health.

The multiple functions of peptides released from proteins have immense potential in food and health. In the past few decades, research interest in bioactive peptides of plant origin has surged tremendously, and new plant-derived peptides are continually discovered with advances in extraction, purification, and characterization technology. Plant-derived peptides are mainly extracted from dicot plants possessing bioactive functions, including antioxidant, cholesterol-lowering, and antihypertensive activities.

Undifferentiated pleomorphic sarcoma of the pancreas: a rare case report and literature review.

Background: Primary undifferentiated pleomorphic sarcoma (UPS) of the pancreas is an exceedingly rare malignant tumor, with only 15 cases have been reported in the medical literature. At present, clinicians have poor recognition of the tumor, the epidemiology, diagnosis, and treatment of this disease have yet not been established.

Case Presentation: In this report, we depict the clinical and imaging characteristics of a 37-year-old man presenting with a primarily cystic UPS.

Current Perspectives on the Unique Roles of Exosomes in Drug Resistance of Hepatocellular Carcinoma.

As a common malignant tumor worldwide, the prognosis of hepatocellular carcinoma (HCC) remains unsatisfactory, even though treatment methods have improved. Despite the developments in traditional chemotherapy and emerging targeted immunotherapy, the problem of recurrence and metastasis of HCC and adverse effects on survival and prognosis are still serious. Drug resistance is a daunting challenge that impedes HCC treatment.

Occurrence, detection, and dissipation of pesticide residue in plant-derived foodstuff: A state-of-the-art review.

Pesticides are indispensably essential in agricultural practices. Traditional pesticides and environmentally friendly pesticides both are used to control the damage caused by pests and diseases. Conventional procedures were carried out to detect pesticide residues using chromatography and spectrophotometric techniques.

Long-Term Exposure to Ambient PM, Sunlight, and Obesity: A Nationwide Study in China.

Background: Accumulated researches revealed that both fine particulate matter (PM) and sunlight exposure may be a risk factor for obesity, while researches regarding the potential effect modification by sunlight exposure on the relationship between PM and obesity are limited. We aim to investigate whether the effect of PM on obesity is affected by sunlight exposure among the general population in China.

Methods: A sample of 47,204 adults in China was included.