Factors associated with impaired arterial adaptation to chronically high wall shear rate in the feeding artery of PTFE grafts.

Background/aims: The feeding artery of dialysis vascular access is subjected to unusually high wall shear stress (WSS), a hemodynamic factor leading to vasodilatation, for at least several months after access creation. Physiologically, high WSS leads to compensatory endothelium-dependent vasodilatation. We supposed that the dilatation of the feeding artery continues to lower WSS during longer time period after access creation and that this process is limited by risk factors of endothelial dysfunction.

Fenofibrate and rosiglitazone improve quality of lipoproteins in patients with type 2 diabetes mellitus.

Background: Particle size distribution in both HDL and LDL is reflected in the fractional esterification rate of cholesterol by lecithin cholesterol acyltransferase (LCAT) in plasma depleted of apoB containing lipoproteins (FER(HDL)). We studied FER(HDL) in a group of patients with type 2 diabetes and determined the impact of two different PPAR agonists (fenofibrate and rosiglitazone) on this marker of lipoprotein particle quality.

Patients And Methods: 66 patients with type 2 diabetes (26 women) and 32 control subjects (19 women) were included in the study.