Publications by authors named "Zdenka Kosarova"
Circulating PIWI-Interacting RNAs piR-5937 and piR-28876 Are Promising Diagnostic Biomarkers of Colon Cancer.
Cancer Epidemiol Biomarkers Prev
September 2018
The early detection of colon cancer is one of the main prerequisites for successful treatment and mortality reduction. Circulating PIWI-interacting RNAs (piRNA) were recently identified as novel promising biomarkers. The purpose of the study was to assess the profiles of piRNAs in blood serum of colon cancer patients with the aim to identify those with high diagnostic potential.
View Article and Find Full Text PDFPurpose: This study aimed at analyzing the association of gene mutations and other acute myeloid leukemia (AML) characteristics with engraftment outcomes in immunodeficient mice and to select the engraftment outcomes that best reflect patient survival.
Methods: Mutations in 19 genes as well as leukemia- and patient-related characteristics were analyzed for a group of 47 de novo AML samples with respect to three engraftment outcomes: engraftment ability, engraftment intensity (percentage of hCD45 cells) and engraftment latency. Leukemia-related characteristics were additionally analyzed in an extended group of 68 samples that included the 47 de novo samples, and additional 21 samples from refractory and relapsed cases.
Article Synopsis
- Early detection of colorectal cancer is crucial for effective treatment; this study focuses on identifying specific serum microRNAs as potential biomarkers for early diagnosis and prognosis.
- Researchers analyzed serum samples from 427 colon cancer patients and 276 healthy individuals, identifying 54 microRNAs that were significantly altered in cancer patients.
- A four-microRNA diagnostic signature (miR-23a-3p, miR-27a-3p, miR-142-5p, and miR-376c-3p) showed high efficacy in distinguishing cancer patients from healthy individuals, with promising results for early-stage diagnoses and prognosis predictions.