Publications by authors named "Zdenka Bujnakova"

Article Synopsis
  • * The composite NPs work by triggering specific cellular pathways leading to cell cycle arrest, activation of apoptosis, and reducing stem cell-like characteristics in MM cells, making them potentially more effective in treatment.
  • * Both formulations of NPs exhibited enhanced effects when combined with established anti-MM drugs like dexamethasone and bortezomib, suggesting important implications for improving clinical outcomes in MM therapy.
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This study shows mechanochemical synthesis as an alternative method to the traditional green synthesis of silver nanoparticles in a comparative manner by comparing the products obtained using both methodologies and different characterization methods. As a silver precursor, the most commonly used silver nitrate was applied and the easily accessible lavender ( L.) plant was used as a reducing agent.

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  • Researchers created CuInSe/ZnS nanocomposites using a two-step mechanochemical process that involved co-milling different precursors in a planetary mill to form the nanocrystals.
  • The synthesized nanoparticles were then stabilized using sodium dodecyl sulfate (SDS), resulting in stable nanosuspensions that maintained their stability for up to 20 weeks.
  • Both nanocomposite suspensions demonstrated the ability to effectively reduce the viability of multiple myeloma cell lines, indicating their potential use in cancer treatment.
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A combination of solid-state mechanochemical and green approaches for the synthesis of silver nanoparticles (AgNPs) is explored in this study. L. (SER), L.

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A semi-industrial approach for simultaneous treatment of eggshell and industrial polyvinyl chloride waste utilizing tools of ball milling is reported therein. On a hundred-gram scale, it is possible to transfer more than 55% of chlorine present in the polyvinyl chloride representing an environmental burden, into harmless soluble form. On a laboratory scale, a complete dechlorination was achieved.

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  • This study examines how zinc oxide nanoparticles (ZnO NPs) affect the growth of Salicornia, a type of halophyte, showing that higher concentrations (1000 mg/L) can reduce shoot length by over 50% compared to untreated plants.
  • The negative impact on plant growth is linked to the release of free zinc(II) ions and the generation of reactive oxygen species (ROS), which alter antioxidant enzyme activities and cause lipid peroxidation.
  • Ultimately, excessive ROS and zinc imbalances trigger oxidative stress, leading to programmed cell death, indicating that even stress-resistant halophytes can suffer from ZnO NPs exposure.
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  • Multiple myeloma (MM) is a type of blood cancer that arises from plasma cells, and despite existing treatments, it remains incurable.
  • A study compared the effectiveness of realgar nanoparticles (NREA) and arsenic trioxide (ATO) in inducing cell death in MM, finding that both reduced tumor size and triggered apoptosis (cell death) in cancer cells.
  • Notably, NREA was more effective than ATO, especially in targeting cancer stem-like cells, and showed enhanced results when used alongside other therapies like lenalidomide and melphalan, suggesting potential for improved patient outcomes.
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The ZnS nanocrystals were prepared in chitosan solution (0.1 wt.%) using a wet ultra-fine milling.

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Within this study, a stable nanosuspension of silver nanoparticles (Ag NPs) was prepared using a two-step synthesis and stabilization approach. The Ag NPs were synthesized from a silver nitrate solution using the Origanum vulgare L. plant extract as the reducing agent.

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Microstructure hierarchical model considering the free-volume elements at the level of interacting crystallites (non-spherical approximation) and the agglomerates of these crystallites (spherical approximation) was developed to describe free-volume evolution in mechanochemically milled AsS/ZnS composites employing positron annihilation spectroscopy in a lifetime measuring mode. Positron lifetime spectra were reconstructed from unconstrained three-term decomposition procedure and further subjected to parameterization using x3-x2-coupling decomposition algorithm. Intrinsic inhomogeneities due to coarse-grained AsS and fine-grained ZnS nanoparticles were adequately described in terms of substitution trapping in positron and positronium (Ps) (bound positron-electron) states due to interfacial triple junctions between contacting particles and own free-volume defects in boundary compounds.

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The wet mechanochemical procedure for the capping of the CdS and CdS/ZnS quantum dot nanocrystals is reported. l-cysteine and polyvinylpyrrolidone (PVP) were used as capping agents. When using l-cysteine, the dissolution of cadmium(II) was almost none for CdS/ZnS nanocrystals.

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Structural transformations caused by coarse-grained powdering and fine-grained mechanochemical milling in a dry mode were probed in high-temperature modification of tetra-arsenic tetra-sulfide known as β-As4S4. In respect to X-ray diffraction analysis, the characteristic sizes of β-As4S4 crystallites in these coarse- and fine-grained powdered pellets were 90 and 40 nm, respectively. Positron annihilation lifetime spectroscopy was employed to characterize transformations occurred in free-volume structure of these nanoarsenicals.

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In this paper the stability of the arsenic sulfide (As4S4) nanosuspension prepared by wet milling in a circulation mill in the environment of copolymer Poloxamer 407 was studied. The obtained As4S4 particles in nanosuspension were of ∼ 100 nm in size. The influence of temperature and UV irradiation on the changes in physical and/or chemical properties was followed.

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