Quality of life in a population of Polish patients with prostate cancer.

Introduction: Recent advances in treatment have led to the prolongation of life among patients with prostate cancer (PCa), which implies greater interest in the issue of the quality of life (QoL) in patients who undergo treatment. The quality of life of patients with cancer questionnaire (QLQ-C30) and the quality of life questionnaire specific to PCa (QLQ-PR25) are tools used worldwide to conduct research on this subject. In our study we assessed the quality of life in a population of Polish patients suffering from prostate cancer.

Significance of atypical small acinar proliferation and extensive high-grade prostatic intraepithelial neoplasm in clinical practice.

Introduction: Prostate cancer (PCa) is one of the most commonly diagnosed neoplasms in elderly men. The precancerous lesion of PCa is considered a high-grade prostate intraepithelial neoplasm (HG-PIN), while atypical small acinar proliferation (ASAP) is commonly considered as an under-diagnosed cancer. The aim of the study was to establish the impact of ASAP and extensive HG-PIN on pre-biopsy prostate-specific antigen (PSA) levels and the risk of cancer development in subsequent biopseis.

Analysis of relative expression level of VEGF ( vascular endothelial growth factor ), HIF-1α ( hypoxia inducible factor 1α ) and CTGF ( connective tissue growth factor ) genes in chronic glomerulonephritis (CGN) patients.

Background/aims: Analysis of gene expression in renal tissue is considered to be a diagnostic tool predicting the clinical course of glomerulonephritis. The present study quantified the relative transcript levels of VEGF, CTGF and HIF-1α in renal tissue to establish their relationship with some clinical variables in patients suffering from chronic glomerulonephritis (CGN).

Methods: 28 patients (6F and 22M, mean age 51.

The relationship of cancer stem cells in urological cancers.

Numerous studies are ongoing to identify and isolate cancer stem cells from cancers of genito-urinary tracts. Better understanding of their role in prostate, urothelial and kidney cancer origin, growth and progression opens new pathways in development of more effective treatment methods. However there are still many issues before advances in this field can be introduced for clinical application.

Inflammatory changes in biopsy specimens from patients with suspected prostate cancer.

Introduction: Prostate cancer (PCa) is one of the most commonly diagnosed cancers in elderly men, and accounts for 30% of all newly diagnosed cases of cancer. The development of the 'clinically insignificant' prostate cancer into its invasive form is still unclear, and it is believed that chronic inflammation may play its role, as proposed by De Marzo in 1999. However, there is no clear opinion on the subject of existence of dependencies between changes of the inflammatory type and PCa.

The role of postoperative radiotherapy in prostate cancer patients.

Aim Of The Study: The aim of the study was to evaluate the effectiveness of postoperative radiotherapy in prostate cancer patients with unfavorable prognostic factors.

Material And Methods: In the years 2002-2008, 121 consecutive prostate cancer patients underwent radical prostatectomy and postoperative radiotherapy. The median dose was 64 Gy (range: 60-72 Gy).

Psychological aspect of qualification to implant an artificial urethral sphincter AMS 800.

Introduction: Implantation of the AMS 800 artificial urethral sphincter is a "gold standard" in the treatment of total urinary incontinence in men. Appropriate qualification of patients to urinary incontinence treatment determines the higher effectiveness of this method. Service of this device requires physical fitness and mental efficiency from a patient.

Is botulinum toxin type a intraprostatic injections really effective in patients with urinary retention?

Botulinum toxin type A is used in treatment of bladder hyperactivity and sphincter dyssynergia and was reported to alleviate lower urinary tract symptoms in patients with BPH. Some authors, however, failed to observe in their study apoptosis after BoNTA administration. We conducted an open-label study of BoNTA in men with BPH-related LUTS who were unsuitable for surgery as well as investigation of the effect of the toxin on in vitro growth of fibroblasts.

Primary cancer of the anterior urethra in a male patient.

We present a 76-year-old male patient, who was diagnosed with transitional cell carcinoma (TCC) of the distal part of the urethra. Transurethral resection of the tumor (TURT) of the urethra was conducted. After establishing local relapse, surgical removal of the distal part of the urethra was proposed to the patient.

Prostate epithelial stem cells are resistant to apoptosis after α1-antagonist treatment. The impact for BPH patients.

Introduction: Induction of apoptosis in prostatic epithelial cells by doxazosin, terazosin and prazosin has been well documented. However, the biochemical pathways of doxazosin action is still unclear. Aforementioned drugs should lead to decrease of prostate volume, although this effect was never observed in patients suffering from BPH after treatment with α1-antagonists.

Credibility of a smoking questionnaire based on urine cotinine level for patients with bladder cancer - a preliminary report.

An analysis of the reliability of a questionnaire on smoking in 96 patients with transitional cell carcinoma (TCC) of the bladder. The credibility of the questionnaire was evaluated based on the detection of cotinine, an objective marker of tobacco smoke exposure, in urine. It was confirmed that approximately 18% of smokers did not admit to smoking, did not comply with recommendations to stop smoking, and about 4% of non-smokers were exposed to tobacco smoke unknowingly.

Uric acid plasma level and urine pH in rats treated with ambroxol.

It was a chance discovery that ambroxol parenteral administration led to urinary bladder stone formation in rats. This study was undertaken to examine the serum uric acid levels and urine pH in rats after ambroxol parenteral treatment. Ambroxol influence on the uric acid level was measured in 5 rats (Rattus sp.

Parenteral ambroxol treatment causes xanthine and calcium oxalate stones in rats.

Introduction: Ambroxol (ABX) is known to promote bronchial secretion and is used as an expectorant. This study was undertaken to document the connection between ambroxol parenteral treatment and bladder stones in rats.

Material And Methods: Forty-five wild rats (Rattus sp.

Palliative percutaneous kidney embolization with enbucrilate in patients with renal cell carcinoma: safety and symptom control.

Background: Primarily palliative renal embolization is a relatively rare procedure which is indicated in patients with unresectable kidney malignancies and in patients in poor general condition. The aim of this paper was to evaluate the role of primarily palliative transarterial renal embolization for the treatment of inoperable patients with renal cell carcinoma, assessing the indications, safety, and efficacy of this procedure.

Material/methods: Seventy-three patients scheduled for palliative embolization between 1998 and 2005 were retrospectively analyzed regarding their medical history, the procedure report, and data from the early postoperative period.

Muscle-invasive urothelial cell carcinoma of the human bladder: multidirectional differentiation and ability to metastasize.

Few published studies have addressed the correlation between multidirectional differentiation in muscle-invasive bladder cancer and its ability to metastasize. We demonstrated that histologic differentiation within a single tumor affects lymph node metastasis. We examined cystectomy specimens from 93 bladder tumors and 1085 lymph nodes.

The FAS-related apoptosis signaling pathway in the prostate intraepithelial neoplasia and cancer lesions.

An aim of the study was to determine the protein expression of the FAS-related apoptosis signaling pathway (FADD-FAS Associating Protein with Death Domain, PRO-CASPASE-8 and CASPASE-8), which are responsible for signal transduction to trigger programmed cell death (apoptosis) in cancer and Prostatic Intraepitelial Neoplasia (PIN). 20 specimens from prostate cancer patients treated with radical prostatectomy were inwestigated. 8 cancers were diagnosed as G-2 and 12 as G-3.

The influence of ambroxol and capsaicin on the isolated rabbit bladder wall.

Unmyelinated C-fibers endings lye beneath the epithelial layer and release neuropeptides which regulate baseline transepithelial potential difference (PD) and changes of transepithelial potential difference during mechanical stimulation (dPD). Ambroxol can suppress reflexes such as the cough or the corneal reflex which are connected to stimulation of C fibre endings. The study aimed to estimate the influence of ambroxol (ABX) and capsaicin (CAPSA) on PD and dPD in isolated rabbit bladder.

Usefulness of histologic homogeneity estimation of muscle-invasive urinary bladder cancer in an individual prognosis: a mapping study.

Objectives: To examine the histologic homogeneity of muscle-invasive urothelial cell carcinoma of the bladder, with conventional and nonconventional (eg, squamous, glandular, or variants) differentiation, to assess its influence on prognosis.

Methods: With organ mapping, we investigated 38 cystectomy specimens. Each entire bladder was cut into 88 slices according to an identical topographic scheme.

Selenium level in benign and cancerous prostate.

The dietary microelement selenium (Se) has been proposed as a potential chemopreventive agent for prostate cancer. This element is present in various amounts in all tissues. Little information is available on Se level in patients with prostate gland disorders.

Abdominal wall repair using a biodegradable scaffold seeded with cells.

Background/purpose: The repair of large abdominal wall defects is still a challenge for pediatric surgeons. Synthetic materials, however, may lead to high complication rates. This study was aimed at applying tissue-engineering methods to abdominal wall repair.

[Comparison of the effectiveness of electrovaporisation, vaporesection and electroresection in the treatment of obstructive symptoms in patients with benign prostate hyperplasia].

Objectives: The aim of this study is the comparison of the efficacy of classical electroresection of the prostate (TURP) and its modern modifications--electrovaporisation (EVAP) and vaporesection (TUVRP) in the treatment of patients with benign prostate hyperplasia (BPH).

Material And Methods: 96 patients were operated on because of BPH. In 31 patients we performed TURP (group I), in 34--EVAP (group II) and in 31--TUVRP (group III).

[Hereditary prostate cancer].

About 10% of the prostate cancer cases were recognized as familial or hereditary. Till now gene/genes responsible for hereditary prostate cancer are not identified. Hereditary prostate cancer case concerning 3 brothers in family of 6 siblings from first marriage and a grandson from second marriage was presented.

[Silicone and latex urinary catheters cytotoxicity on primary cultured rabbit urothelial cells].

Unlabelled: In everyday urological practice, the use of urinary catheters creates problems such as epithelial hyperplasia, edema or erosion.

The Aim: of this study is estimation of the toxicity of latex and silicone urinary catheters on primary cultured rabbit urothelial cells (PRUCC) was compared.

Materials And Methods: Primary cultured rabbit urothelial cells (PRUC) were characterized for their proliferation, qualitative evaluation and quantitative measurement of cytokeratins.

The presence and structure of circulating immune complexes in patients with prostate tumors.

Background: The detection, measurement and characterization of circulating immune complexes (CICs) in tumor patients has shown both good and poor correlation with progression of the disease. The origin of the antigens making up the immune complexes in the sera of the cancer patients examined is unknown. They are perhaps antigens specific to the cancer's progress.