Impact of an exercise training program on cardiac neuronal function in heart failure patients on optimal medical therapy : A randomized Iodine-123 metaiodobenzylguanidine scintigraphy study.

Background: The syndrome of heart failure (HF) is characterized by left ventricular dysfunction and a compensatory chronic over activation of the sympathetic nervous system. We wanted to investigate if the beneficial effects of exercise training (ET) in HF patients on optimal medical therapy (OMT) are associated with alterations in cardiac sympathetic activity.

Methods: Cardiac sympathetic activity was evaluated at baseline and after 12 weeks using metaiodobenzylguanidine scintigraphy in 23 patients with stable HF participating in the SmartEx trial.

Using spatially explicit indicators to investigate watershed characteristics and stream temperature relationships.

We generate a series of novel indicators of spatially explicit watershed permeability and runoff characteristics to examine the relationship between land cover and water temperature parameters in a rapidly urbanizing watershed. Our framework provides a readily adaptable method to examine the thermal sensitivity of streams based upon the underlying geomorphological and surface characteristics of drainage basins. Using four model groups each using a different landscape characteristic weighting scheme (Model Group 1: areal averages; Model Group 2: inverse distance by total flow length; Model Group 3: overland distance to stream network and distance squared; Model Group 4: proportional flow accumulation), we examined the predictive capacity of 19 variables, including combinations of simplified land cover, elevation, slope, and flow accumulation, on five stream thermal properties: seven day moving average of daily minimum and maximum, seasonal mean temperature, a novel metric of thermal 'flashiness', and total days with maximum temperature exceeding 17.

Solvent polarity and hydrogen-bonding effects on the nitrogen NMR shieldings of N-nitrosamines and DFT calculations of the shieldings of C-, N-, and O-nitroso systems.

High-precision nitrogen NMR shieldings, bulk susceptibility corrected, are reported for dimethyl-N-nitrosamine (I) and diethyl-N-nitrosamine (II) in a variety of solvents which represent a wide range of solvent properties from the point of view of polarity as well as hydrogen bond donor and acceptor strength. The observed range of solvent-induced nitrogen shielding variations of (I) and (II) is significant for the amino-type nitrogens, up to about 16 ppm, and originates essentially from the deshielding effect of the increasing polarity of solvent. On the other side, the nitroso nitrogen shieldings reveal an even stronger response to solvent effects, within about 20 ppm, but in this case the increasing polarity and hydrogen bond donor strength of solvent produce enhanced shielding.