Publications by authors named "Zazpe I"

Background/objectives: Noncommunicable diseases, particularly cardiovascular disease (CVD), represent a significant global public health challenge, with unhealthy diets as a major risk factor. This study investigates the association between adherence to the Planetary Health Diet proposed by the EAT-Lancet Commission and CVD risk.

Methods: Utilizing data from the Seguimiento Universidad de Navarra (SUN) cohort, which included 18,656 participants (mean age 38 years; 61% women), we assessed dietary intake using a validated food frequency questionnaire and the Planetary Health Diet Index to evaluate adherence (range 0-42).

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: The rising prevalence of pediatric obesity highlights the urgent need for effective lifestyle interventions that improve diet quality, in line with global health objectives. Tackling obesity through planetarian dietary practices not only enhances individual health but also mitigates the environmental impact of food systems. The EAT-Lancet Commission's plant-based dietary recommendations underscore the dual benefit of promoting human health while supporting environmental sustainability.

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Unlabelled: This study aims to examine the association between different versions of a provegetarian food pattern and micronutrient adequacy in a population of children from the SENDO Project. Children aged 4-5 years old were recruited and baseline information on diet, lifestyle and socio-demographic characteristics was collected through self-administered online questionnaires completed by their parents. Scores were calculated for overall, healthful, and unhealthful provegetarian food patterns (FP) using an a priori approach.

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Background & Aims: The double burden of malnutrition compels us to reconsider macronutrients from a diet quality perspective. The Macronutrient Quality Index (MQI) has been designed to reflect overall macronutrient quality and is based on three sub-indexes: the carbohydrate quality index (CQI), the healthy plate protein quality index (HPPQI) and the fat quality index (FQI). Nutritional adequacy is an essential aspect of diet quality that should be captured by reliable dietary indexes.

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Introduction: no previous large prospective studies have assessed the global quality of macronutrients in association with the risk of overweight/obesity. Objective: to prospectively assess the association of an overall macronutrient quality index (MQI) with weight change and the incidence of overweight/obesity in the Seguimiento Universidad de Navarra (SUN) cohort. Methods: the diet of 9,344 Spanish university graduates free of overweight/obesity (mean age: 36.

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Article Synopsis
  • The introduction highlights the benefits of using an endoscope in skull base surgery, particularly for pituitary neuroendocrine tumors (PitNet), allowing for better tumor resection while preserving important gland tissue, but requiring specialized skills to master the technique.* -
  • The research involved a survey with 11 neurosurgical experts from the EANS to establish a consensus on the endoscopic endonasal approach for pituitary adenoma surgery, encompassing various aspects like demographics, surgical methods, and post-operative management.* -
  • The findings present key strategies and considerations for successful endoscopic pituitary surgery, emphasizing surgical technique, understanding of anatomical variations, and collaboration with experts from related fields to minimize complications.*
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Suboptimal micronutrient intake in children remains a public health concern around the world. This study examined the relationship between a previously defined dietary carbohydrate quality index (CQI) and the risk of micronutrient intake inadequacy in a pediatric cohort of Spanish preschoolers. Children aged 4-5 years old were recruited at their medical center or at school, and information on sociodemographic, dietary, and lifestyle variables were collected through a self-administered online questionnaire.

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Article Synopsis
  • Invasive growth of meningiomas into brain tissue is rare but important for patient outcomes, and opinions on its impact differ.
  • A survey was conducted to see how different hospitals collect samples of tumors, revealing many don’t follow a standard method.
  • The study suggests that hospitals should have a more structured way of collecting samples during surgery to better understand if the tumor has invaded brain tissue.
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Objectives: Dietary patterns may have a greater influence on human health than individual foods or nutrients, and they are also of substantial interest in the field of breast cancer prevention. Beyond the adequate balance of macronutrients, evidence indicates that the quality of macronutrient sources may play an important role in health outcomes. We sought to examine the relationship between healthful and unhealthful low-fat dietary patterns in relation to breast cancer.

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•OGM surgery is much more complex than a simple debate of "from above or from below" (transcranial vs endoscopic).•Lateral Sub-frontal and Superior Interhemispheric seem the most effective, superior and versatile approaches for OGM.•Minimally Invasive Transcranial approaches showed no inferiority in OGM sized <4 ​cm.

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Introduction: The optimal surgical treatment for giant pituitary neuroendocrine tumors(GPitNETs) is debated.

Research Question: The aim of this paper is to optimize the surgical management of these patients and to provide a consensus statement on behalf of the EANS Skull Base Section.

Material And Methods: We constituted a task force belonging to the EANS skull base committee to define some principles for the management of GPitNETs.

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Introduction: Cushing's disease is a state of chronic and excessive cortisol levels caused by a pituitary adenoma.

Research Question: CD is a complex entity and often entails difficulties in its diagnosis and management. For that reason, there are still controversial points to that respect.

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Objective: To investigate the association between different versions of a provegetarian food pattern (FP) and micronutrient inadequacy.

Design: Cross-sectional analysis. Dietary intake was assessed at baseline through a validated 136-item FFQ.

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Purpose: There is no evidence of a dietary index that measures not only the quantity but also the quality of protein. The aim is to investigate the association between a new dietary protein quality index (PQI) and micronutrient intake adequacy in a Mediterranean cohort.

Design: We assessed 17,535 participants' diet at baseline using a semi-quantitative FFQ.

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Purpose: To assess the association between a multi-dimensional Macronutrient Quality Index (MQI) and the risk of cardiovascular disease (CVD) in a Mediterranean cohort.

Methods: Prospective analyses among 18,418 participants (mean age 36 years, 60.8% women) of the Seguimiento Universidad de Navarra (SUN) cohort.

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Background: Non-vestibular schwannomas are relatively rare, with trigeminal and jugular foramen schwannomas being the most common. This is a heterogenous group which requires detailed investigation and careful consideration to management strategy. The optimal management for these tumours remains unclear and there are several controversies.

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Background: Non-vestibular schwannomas are relatively rare, with trigeminal and jugular foramen schwannomas being the most common. This is a heterogenous group which requires detailed investigation and careful consideration to management strategy. The optimal management for these tumours remains unclear, and there are several controversies.

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Purpose: It is difficult to change dietary habits and maintain them in the long run, particularly in elderly people. We aimed to assess whether adherence to the Mediterranean diet (MedDiet) and cardiovascular risk factor were similar in the middle-aged and oldest participants in the PREDIMED study.

Methods: We analyzed participants belonging to the first and fourth quartiles of age (Q1 and Q4, respectively) to compare between-group differences in adherence to the nutritional intervention and cardiovascular risk factor (CRF) control during a 3-year follow-up.

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Background: Non-vestibular schwannomas are relatively rare, with trigeminal and jugular foramen schwannomas being the most common. This is a heterogeneous group which requires detailed investigation and careful consideration to management strategy. The optimal management for these tumours remains unclear, and there are several controversies.

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Purpose: To assess the association between a score appraising adherence to the PaleoDiet and the risk of cardiovascular disease (CVD) in a Mediterranean cohort.

Methods: We included 18,210 participants from the Seguimiento Universidad de Navarra (SUN) cohort study. The PaleoDiet score comprised six food groups promoted within this diet (fruit, nuts, vegetables, eggs, meat and fish) and five food groups whose consumption is discouraged (cereals and grains, dairy products, legumes, culinary ingredients, and processed/ultra-processed foods).

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Background: The optimal management of clinoidal meningiomas (CMs) continues to be debated.

Methods: We constituted a task force comprising the members of the EANS skull base committee along with international experts to derive recommendations for the management of these tumors. The data from the literature along with contemporary practice patterns were discussed within the task force to generate consensual recommendations.

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Aggressive pituitary neuroendocrine tumors (APT) account for 10% of pituitary tumors. Their management is a rapidly evolving field of clinical research and has led pituitary teams to shift toward a neuro-oncological-like approach. The new terminology "Pituitary neuroendocrine tumors" (PitNet) that was recently proposed to replace "pituitary adenomas" reflects this change of paradigm.

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Introduction: the preschool stage is a critical period for teaching and modeling healthy habits to positively influence children's health and wellbeing throughout their lifetime. Objectives: to evaluate the association between parental attitudes towards their offspring's dietary habits in Spanish children aged 4 to 7 years participating in the Follow-up of Children for Optimal Development (SENDO) project. Methods: we defined an index to measure information on parental attitudes towards their offspring's diet (0 to 8 points), and another one to measure children's actual dietary habits (0 to 19 points).

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Article Synopsis
  • Glioblastoma multiforme is the most common and aggressive brain tumor, currently lacking effective therapies.
  • High levels of mesenchymal markers and increased autophagy are observed in glioblastoma cells, indicating a complex disease pathogenesis.
  • Silencing HDAC6 in glioblastoma cell lines showed reduced tumor cell growth and migration, reversed aggressive traits, and suggests HDAC6 as a potential therapeutic target.
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