Publications by authors named "Zaw H Phyo"
Article Synopsis
- PTPN22 is identified as a key regulator in T cell signaling related to autoimmune diseases, but its role in cancer and potential as a therapeutic target was unclear until now.
- A specific genetic variant of PTPN22 (rs2476601) is linked to a lower risk of cancer and enhanced immune responses in patients, indicating its importance in tumor regulation.
- Research in mice demonstrates that inhibiting PTPN22 boosts anti-tumor activity by stimulating immune cells, and combining PTPN22 inhibitors with PD1 blockade shows promise for improving cancer immunotherapy outcomes.
Cutaneous T cell lymphomas (CTCL) comprise of a heterogeneous group of non-Hodgkin lymphomas derived from skin-homing T cells. Variation in clinical presentation and lack of definitive molecular markers make diagnosis especially challenging. The biology of CTCL remains elusive and clear links between genetic aberrations and epigenetic modifications that would result in clonal T cell expansion have not yet been identified.
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