Proteome Changes Paralleling the Olfactory Conditioning in the Forager Honey Bee and Provision of a Brain Proteomics Dataset.

The olfactory conditioning of the bee proboscis extension reflex (PER) is extensively used as a paradigm in associative learning of invertebrates but with limited molecular investigations. To investigate which protein changes are linked to olfactory conditioning, a non-sophisticated conditioning model is applied using the PER in the honeybee (Apis mellifera). Foraging honeybees are assigned into three groups based on the reflex behavior and training: conditioned using 2-octanone (PER-conditioned), and sucrose and water controls.

[Hospital-based Health Technology Assessment].

Hospital-based HTA (HB-HTA) consists in implementation of assessment activities "in" or "for" hospitals; hence, it covers processes and methods supporting organization and execution of health technology assessment (HTA) at the level of individual hospitals. This process is multidisciplinary, systematic and evidence-based.HB-HTA objectives and methods differ from the classic utilization of HTA at the national regulator level.

[New diagnostic approach to different hydatidiform mole types, hydropic abortions and relevant clinical management].

Objective: To describe new diagnostic approach to complete hydatidiform mole, immature complete hydatidiform mole, partial hydatidiform mole, proliferative mole and hydropic abortion.

Type Of Study: Original research.

Setting: Trophoblastic Disease Center in the Czech Republic (TDC-CZ), Institute for the Care of Mother and Child, Prague.

[Histological differential diagnosis of hydatidiform moles and hydropic abortions].

Objective: To describe the diagnostic methods enabling histological differential diagnosis of complete hydatidiform mole, immature complete hydatidiform mole, partial hydatidiform mole, proliferative mole and hydropic abortion.

Methods: Our study consists of 1321 partial hydatidiform moles, 805 complete hydatidiform moles, 524 proliferative moles, and over 2500 hydropic abortuses diagnosed and treated at the Trophoblastic Disease Center in the Czech Republic (TDC-CZ), Institute for the Care of Mother and Child, plus 2896 of these lesions examined at the TDC-CZ by referral. The material was examined by routine histopathological methods, which in selected cases were supplemented by immunohistological examination and correlated with cytogenetic and molecular genetic results and clinical features.

[Persistent trophoblastic disease in Trophoblastic Disease Center in the Czech Republic in 1955--2007].

Objective: To define persistent trophoblastic disease as a clinical entity of gestational trophoblastic disease. To describe its classification, treatment and follow-up.

Type Of Study: Retrospective analysis.

[Tumoriform endometriosis of the urinary bladder in advanced pregnancy].

A case of tumoriform endometriosis of urinary bladder immitating a tumor of the bladder during the first pregnancy of a 25-year-old patient was successfully treated by partial cystectomy allowing continuation of the pregnancy, a normal term delivery and after 5 months a second pregnancy with term delivery.

[Syndrome of persistent low levels of human chorionic gonadotrophin (hCG)].

Objective: To analyze the syndrome of persistent low levels of hCG in terms of its etiology, classification, diagnosis, and management.

Design: Retrospective analysis.

Setting: Center for Trophoblastic Disease in Czech Republic, Institute for Care of Mother and Child, Prague, Institute of Postgraduate medical education, IPVZ, Prague

Methods: An analysis of the syndrome of persistent low levels of hCG recorded in CTN in 29 women in the years 1979-2005 by the immunoluminesence method which can quantitatively assess variable levels of hCG in blood and urine.

[Endometriosis imitating bladder tumor in 2nd trimester of pregnancy].

Objective: Case presentation of bladder endometriosis during 2nd trimester imitating urinary bladder tumour.

Setting: Mother and Child Care Institute, Prague. III.

[Malignant trophoblastic tumors (MTT) treated in the years 1955-2004 in trophoblastic disease center in the Czech Republic (TDC-CZ): clinical-pathological features, curability, typing, pathogenesis].

Objective: Clinical- pathological features, typing, curability and pathogenesis of malignant tumors of trophoblast (MTT).

Design: A retrospective analysis.

Setting: Trophoblastic Disease Center in the Czech Republic (TDC-CZ), Mother and Child Care Institute, 3rd Medical Faculty, Charles University, Prague.

[Undifferentiated choriocarcinoma--epithelioid trophoblastic tumors treated at the Center for Trophoblastic Diseases in the Czech Republic 1955-2003].

Objective: The clinical-pathological picture, pathogenesis, biological behavior and therapy of epithelioid trophoblastic tumor (ETT) alias undifferentiated choriocarcinoma (CH-Ned).

Design: A retrospective analysis.

Setting: Trophoblastic Disease Center in the Czech Republic (TDC-CZ), Department of Gynecology and Obstetrics, 3rd Medical Faculty, Charles University, Institute for the Care of Mother and Child, Prague.

[Proliferating mole in menopause imitating choriocarcinoma recurrence--case report].

Objective: To show the possibility of new invasive mole arising after 2 years of menopause, after choriocarcinoma cured by chemotherapy 5 years ago.

Setting: Trofoblastic disease center (TDC), Prague, Institution for care of mother and child, Prague.

Case Report: Patient 50-years-old with choriocarcinoma, in consequence to invasive mole, was cured by chemotheraphy.

[Ovarian implantation of the embryo in IVF and ET--early mole with proliferative trophoblast].

Objective: Case report of a very rare case of ovarian implantation after IVF and ET treated by laparoscopy.

Design: Case report.

Setting: Institute for the Care of Mother and Child, Prenatal Diagnostic Centre and Trophoblastic Disease Centre, Prague, Institute for Postgraduate Medical Education, Prague.

Long term follow-up study of laryngeal precancer.

The goal of this study was to determine subsequent malignancy on a discrete group of precancerous laryngeal lesions, and to assess the mortality. In a series of 227 patients, average age 51.8 years (ranging from 13 to 80 years).

[The importance of hormone receptors in benign breast diseases].

Benign breast lesions are usually divided with regard to the proliferative activity into three categories. These lesions, depending on their histopathological characteristics and correlation with epidemiological studies differ as to the risk of breast cancer. 1.

[Trophoblastic disease in data from the Center for Trophoblastic Disease (diagnosis, therapy and results form 1955 to 1996). 1].

The authors submit an analysis of the clinical pathological material of the nationwide trophoblastic diseases centre (CTN) from 1955-1996. It comprises a total of 5735 cases of trophoblastic disease (TN). This comprises choriocarcinoma (CH) 343 times, so far the largest group of CH verified by histological examination.

[Breast carcinoma with endometrial metastasis diagnosed with biopsy-curettage].

A rare case of extragenital carcinoma metastatic to endometrium was described. Diagnosis of primary mammary lobular carcinoma was established from curettment.

[Pregnancy after chemotherapy in malignant forms of gestational trophoblastic disease].

The authors reviewed the subsequent pregnancy experience in patients with malignant gestational trophoblastic disease who were managed at the Czechoslovak Trophoblastic Disease Center between January 1981 to December 1990. Thirty-five women who conceived following successful chemotherapy of gestational trophoblastic disease subsequently became pregnant a total of 53 times. Twenty-seven of these 53 pregnancies or 51% terminated in live-born infants.