[The spectral characteristics of the effect of central M-cholinolytics on rat behavior under open-field conditions].

Having estimated the rat behaviour in the open-field test, M-cholinolytics were divided into different groups. Haloperidol normalised the disturbance in the behaviour induced by one group M-cholinolytics and had no effect with the other group. The former group seems to have an explicit dopaminergic activity.

[New molecular mechanism of the blockade of neuronal N-cholinoreceptors].

Antioxidants and disulphide bond reducing agents have shown the central N-cholinolytic effect and prevented nicotinic-induced contraction of isolated smooth muscle preparation (ISMP). N-cholinolytic pediphen and antioxidant ionol reduced disulphide bond in the supernatant of mouse brain, but sulphydryl-oxidant agents 5'5-Dithiobis (2-nitrobenzoic acid) abolished N-cholinolytic effect of pediphen on ISMP. It is concluded that reduction of disulphide bond of N-cholinoceptor is a molecular mechanism of its blockade.

[Action of antioxidants on membrane-toxic effects of anticholinesterase agents].

It was found therapeutic-preventive effectiveness of antioxidants (1,4-dihydropyridine derivatives) at poisoning with malathion insecticide. The effect of 1,4-dihydropyridine derivatives can be attributed to a prevention of lipid peroxidation. Antioxidants do not affect the toxicity of 0,0-dimethyl-0-2,2-dichlorvinylphosphate.

[Effect of central cholinolytics on the process of lipid peroxidation].

The effect of central M- and N-cholinolytics on Fe++-ascorbate-dependent lipid peroxidation (LP) in the rat brain homogenate was studied in vitro. Central N-cholinolytics were shown to inhibit LP. Pediphen was the most active drug.