Publications by authors named "Zarina Ali"

Objective: The Social Deprivation Index (SDI) measures area-level social disadvantage. SDI values range from 0 (no distress/prosperous) to 100 (highest distress). This study investigated the association between SDI and lumbar spine surgery outcomes.

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Objective: Intraoperative antifibrinolytic therapy with tranexamic acid (TXA) is a focus of interest for blood loss reduction in multilevel adult spinal deformity (ASD) correction surgery. There is considerable heterogeneity in the reported findings regarding the safety and efficacy of this therapy. In the present study, the authors aimed to rigorously investigate the safety and efficacy of TXA in multilevel ASD correction surgery and to explore secondary perioperative outcomes.

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Objective: Smartphones and wearable devices can be effective tools to objectively assess patient mobility and well-being before and after spine surgery. In this retrospective observational study, the authors investigated the relationship between these longitudinal perioperative patient activity data and socioeconomic and demographic correlates, assessing whether smartphone-captured metrics may allow neurosurgeons to distinguish intergroup patterns.

Methods: A multi-institutional retrospective study of patients who underwent spinal decompression with and without fusion between 2017 and 2021 was conducted.

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Prescription opioids after surgery may pose a risk if left unused. However, prescribers rely on their best judgement in determining how much their patients need, often resulting in over-prescription of these medications. Opioid disposal is a strategy to reduce the risk of persistent use or misuse of opioids.

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Objective: The aim of this study was to describe the effect of opioid prescribing guideline implementation for elective spine surgery cases on prescribing and consumption behaviors in a multisite academic hospital system. The effectiveness of an automated text messaging system as a tool to monitor postoperative opioid use and pain outcomes and inform guideline development and deployment is also evaluated.

Methods: The authors conducted a prospective study of postoperative opioid use behaviors and patient-reported outcomes for 2101 elective spine surgery cases between December 2018 and March 2022, prior to and following the implementation of opioid-prescribing guidelines in February 2021 at three urban hospital sites within a large academic health system.

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Objective: Fractures of the atlas are typically considered stable or unstable based on the integrity of the transverse ligament. Whereas stable Jefferson burst fractures can be treated nonoperatively, unstable fractures with disruption of the transverse ligament often require surgical intervention. Atlas osteosynthesis has been proposed as a motion-preserving alternative to atlantoaxial fusion.

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Objective: Neurosurgical operations, including spine surgeries, often occur outside "normal business hours" due to the urgent or emergent nature of cases. This study investigates the association of surgical start time (SST) with spine surgery outcomes.

Methods: A retrospective cross-sectional study was performed using electronic health record data from a multi-hospital academic health system from 2017 to 2024.

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Objective: Surgical correction of adult spinal deformity (ASD) is associated with a high rate of hardware complication that can be challenging to predict. Hardware integrity and alignment after surgery are typically followed with standing radiography, where pedicle screw loosening may be incidentally identified but the clinical significance of which is often unclear. This study aimed to identify the incidence and implications of pedicle screw loosening at the upper instrumented vertebra (UIV) after surgical correction of ASD.

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Purpose: This study aimed to investigate the relationship of preoperative hemoglobin levels as an independent prognostic factor for hospital and intensive care unit (ICU) length of stay (LOS) in patients undergoing surgery for adult spinal deformity (ASD), with the intent of determining whether there exists a correlation and enhancing patient preoperative optimization protocols.

Methods: The authors reviewed consecutive patients who underwent elective thoracolumbosacral posterior spinal fusion (PSF) involving six or more vertebrae for ASD from January 1, 2013, to December 13, 2021, with a minimum follow-up period of two years. This study primarily investigated the association of preoperative hemoglobin levels with hospital and ICU LOS.

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Objective: Common peroneal (fibular) neuropathy is the most common mononeuropathy of the lower extremity. Despite this, there are surprisingly few studies on the topic, and a knowledge gap remains in the literature. As one attempts to address this knowledge gap, a core outcome set (COS) is needed to guide the planning phases of future studies to allow synthesis and comparability of these studies.

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Objective: When considering traumatic brachial plexus and upper extremity nerve injuries, iatrogenic nerve injuries, and nontraumatic nerve injuries, brachial plexus and upper extremity nerve injuries are commonly encountered in clinical practice. Despite this, data synthesis and comparison of available studies are difficult. This is at least in part due to the lack of standardization in reporting and a lack of a core outcome set (COS).

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Background And Objectives: Race has implications for access to medical care. However, the impact of race, after access to care has been attained, remains poorly understood. The objective of this study was to isolate the relationship between race and short-term outcomes across patients undergoing a single, common neurosurgical procedure.

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Objective: Balancing surgical pain management and opioid stewardship is complex. Identifying patient-level variables associated with low or no use can inform tailored prescribing.

Methods: A prospective, observational study investigating surgical procedures, prescription data, and patient-reported outcomes at an academic health system in Pennsylvania.

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Article Synopsis
  • Technological advancements are revolutionizing medical education, with a focus on utilizing AI tools like ChatGPT to improve neurosurgical board training by assessing its effectiveness against exam practice questions.
  • The research involved analyzing ChatGPT's responses to the Congress of Neurologic Surgeons' Self-Assessment Neurosurgery Exam questions, using a unique evaluation matrix to measure the quality, accuracy, and clarity of the answers provided.
  • Results indicated ChatGPT's accuracy varied by topic, achieving approximately 66.7% accuracy overall, and while some responses surpassed standard explanations, there remain challenges in integration, highlighting the need for further research to improve AI applications in medical education.
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Article Synopsis
  • This study compares the outcomes and costs of staged (ST) versus same-day (SD) circumferential spinal fusion surgeries for adult spinal deformity correction over a period from 2013 to 2018.
  • A total of 211 patients were reviewed, focusing on factors such as surgical details, complications, readmissions, and hospital costs, applying statistical methods to account for differences in patient characteristics between the two groups.
  • Results indicated that while ST procedures had higher rates of postoperative pulmonary embolism and longer hospital stays, overall 30-day readmission and reoperation rates were similar between the ST and SD groups after statistical adjustment.
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Objective: To conduct a prospective, randomized controlled trial (RCT) of an enhanced recovery after surgery (ERAS) protocol in an elective spine surgery population.

Background: Surgical outcomes such as length of stay (LOS), discharge disposition, and opioid utilization greatly contribute to patient satisfaction and societal healthcare costs. ERAS protocols are multimodal, patient-centered care pathways shown to reduce postoperative opioid use, reduced LOS, and improved ambulation; however, prospective ERAS data are limited in spine surgery.

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Background: Brachial plexus region tumors are rare. In this study, we reviewed our experience with resection of tumors involving or adjacent to the brachial plexus to identify patterns in presentation and outcome.

Methods: We report a retrospective case series of brachial plexus tumors operated on by a single surgeon at a single institution over 15 years.

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Objective: Patient-reported outcome measures (PROMs) are the gold standard for assessing postoperative outcomes in spine surgery. However, PROMs are also limited by the inherent subjectivity of self-reported qualitative data. Recent literature has highlighted the utility of patient mobility data streamed from smartphone accelerometers as an objective measure of functional outcomes and complement to traditional PROMs.

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Article Synopsis
  • Posterior cervical foraminotomy (PCF) and anterior cervical discectomy and fusion (ACDF) are two surgical methods for treating cervical radiculopathy, and this study compares their effectiveness.
  • The research analyzed data from patients who underwent either surgery from 2014 to 2021, including factors like demographics, surgery details, and reoperation rates.
  • Findings showed no significant difference in reoperation rates or effectiveness between the two procedures, but ACDF resulted in longer hospital stays and higher readmission rates.
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Background: There remains a number of factors thought to be associated with survival in spinal metastatic disease, but evidence of these associations is lacking. In this study, we examined factors associated with survival among patients undergoing surgery for spinal metastatic disease.

Methods: We retrospectively examined 104 patients who underwent surgery for spinal metastatic disease at an academic medical center.

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Postoperative C5-6 palsies can occur in 5%-10% of cases after cervical spine surgery. In this video, the authors demonstrate operative techniques for nerve transfer to restore function for postoperative C5-6 palsy. The patient underwent C3-6 laminectomy and posterior fusion for cervical spondylotic myelopathy and developed weakness postoperatively in the C5-6 distribution bilaterally.

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Acellularized nerve allografts (ANAs) have been developed as substitutes for nerve autograft to promote nerve regeneration after surgical repair. In this video, the authors demonstrate operative techniques for using ANAs to repair potentially functional nerve fascicles during tumor resection. A 67-year-old female with schwannomatosis requested resection of a painful enlarging mass of the left ulnar nerve proximal to the elbow.

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Objective: Prior work reveals that Enhanced Recovery After Surgery (ERAS) programs decrease opioid use, improve mobilization, and shorten length of stay (LOS) among patients undergoing spine surgery. The impact of ERAS on outcomes by race/ethnicity is unknown. This study examined outcomes by race/ethnicity among neurosurgical patients enrolled in an ERAS program.

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Study Design: : Retrospective Chart Review.

Objectives: Incidental durotomies (IDs) are common spine surgery complications. In this study, we present a review on the most commonly utilized management strategies, report our institutional experience with case examples, and describe a stepwise management algorithm.

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Article Synopsis
  • Major peripheral nerve injury (PNI) presents difficulties in functional restoration due to slow axon growth and degeneration of the regenerative pathway without axons.
  • Researchers are creating tissue-engineered nerve grafts (TENGs) using porcine neurons and stretching techniques to provide living axons that help guide the regeneration of host axons and maintain nerve pathways.
  • TENGs have shown success in accelerating axon regeneration across both short (1 cm) and long (5 cm) nerve defects in pigs, achieving recovery comparable to traditional autograft methods, and showing promise for treating currently unrepairable PNIs.
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