Resistance Training and Resveratrol Supplementation Improve Cancer Cachexia and Tumor Volume in Muscle Tissue of Male Mice Bearing Colon Cancer CT26 Cell Tumors.

Losing muscle functions due to reducing muscle mass and quality is one of the main features of cancer cachexia that impairs patients' quality of life and decrease their survival. This study aimed to investigate the synergistic effects of resistance training and resveratrol supplementation on cachexia induced by CT26 tumors in male mice. Forty-eight mice were divided into eight groups randomly: healthy sedentary vehicle (HSV), healthy exercise vehicle (HEV), healthy sedentary resveratrol (HSR), healthy exercise resveratrol (HER), CT-26 tumor-bearing sedentary vehicle (TSV), CT-26 tumor-bearing exercise vehicle (TEV), CT-26 tumor-bearing sedentary resveratrol (TSR) and CT-26 tumor-bearing exercise resveratrol (TER).

Alterations in FoxO3a, NF-κB, and MuRF1 Expression in the Soleus Muscle of Male Rats Following High-Intensity Interval Training and Detraining.

Activation of the transcription factors FoxO3a and NF-κB is necessary for muscle atrophy, which occurs during cancer cachexia and detraining. It is not known how high-intensity interval training (HIIT) and detraining affect activation of these pathways. Two-month-old male Sprague-Dawley rats were assigned to sedentary control (SC) (n = 6) and HIIT (HIIT) (n = 18) groups.

Therapeutic effects of nanosilibinin in valproic acid-zebrafish model of autism spectrum disorder: Focusing on Wnt signaling pathway and autism spectrum disorder-related cytokines.

In this study, we delved into the intricate world of autism spectrum disorder (ASD) and its connection to the disturbance in the Wnt signaling pathway and immunological abnormalities. Our aim was to evaluate the impact of silibinin, a remarkable modulator of both the Wnt signaling pathway and the immune system, on the neurobehavioral and molecular patterns observed in a zebrafish model of ASD induced by valproic acid (VPA). Because silibinin is a hydrophobic molecule and highly insoluble in water, it was used in the form of silibinin nanoparticles (nanosilibinin, NS).

Monitoring Alzheimer's disease via ultraweak photon emission.

In an innovative experiment, we detected ultraweak photon emission (UPE) from the hippocampus of male rat brains and found significant correlations between Alzheimer's disease (AD), memory decline, oxidative stress, and UPE intensity. These findings may open up novel methods for screening, detecting, diagnosing, and classifying neurodegenerative diseases, particularly AD. The study suggests that UPE from the brain's neural tissue can serve as a valuable indicator.

Different paradigms of transcranial electrical stimulation induce structural changes in the CA1 region of the hippocampus in a rat model of Alzheimer's disease.

One of the prominent sign of Alzheimer's disease (AD) is structural changes in the hippocampus. Recently, the new methods used to treat this disease is transcranial electrical stimulation (tES). This study evaluated the effect of four primary standards of tES, including tDCS, tACS, tRNS, and tPCS on beta-amyloid 25-35 (Aβ25-35)-induced structural changes in the CA1 region of hippocampus in male rats.

Comparison of the efficacy of human umbilical cord mesenchymal stem cells conditioned medium and platelet-rich plasma on the hippocampus of STZ-induced rat model of Alzheimer's disease: A behavioral and stereological study.

Introduction: Alzheimer's disease (AD) is accompanied by progressive cognitive disorders and memory loss. This study aims to determine the combined effects of conditioned medium of human umbilical cord mesenchymal stem cells (CM) and platelet-rich plasma (PRP) on AD model rats.

Methods: Forty-eight male Sprague Dawley rats were classified into 6 groups: Control, Sham, AD, and three treatment groups.

Near-perfect wide-band absorbers based on one-dimensional photonic crystal structures in 1-20 THz frequencies.

This paper investigates the absorption behavior of one-dimensional (1D) photonic crystal (PhC) structures in the 1-20 THz region. The structures are analyzed by the transfer matrix method to achieve accurate results quickly with ordinary simulation facilities. The simulation results indicate a strong dependence of the absorber performance on the thickness and material of the PhC layers, as well as the frequency and angle of incident light.

Interactive Effects of Swimming High-Intensity Interval Training and Resveratrol Supplementation Improve Mitochondrial Protein Levels in the Hippocampus of Aged Rats.

Mitochondrial dysfunction and increased oxidative stress cause damage to cells which can lead to the aging process and age-related diseases. Antioxidants such as resveratrol and high-intensity exercise can benefit oxidative damage prevention. This study is aimed at evaluating the effects of swimming high-intensity interval training and resveratrol on mitochondrial metabolism key proteins, SIRT5, SOD1, and PDH-E1, and the level of NAD as a cofactor in the deacetylation process in aged rat hippocampus.

Simultaneous all-optical sampling and quantization scheme based on the nonlinear Kerr effect in an ultra-compact silicon waveguide grating structure.

In this paper, a novel method for simultaneous all-optical sampling and quantization is presented, to the best of our knowledge. This study utilizes the nonlinear Kerr effect in a silicon-based waveguide grating to realize nonlinear filters in which the sampling pulses are affected by the input signal. Compatible with complementary metal-oxide-semiconductor fabrication, in this ultra-compact two-bit quantizer, the footprint is reduced to 90µ which, to the best of our knowledge, is the least among recent similar studies.

The effect of chronic stress and its preconditioning on spatial memory as well as hippocampal LRP1 and RAGE expression in a streptozotocin-induced rat model of Alzheimer's disease.

According to available evidence, prolonged or chronic exposure to stress is detrimental to various brain structures, including the hippocampus. The current study examined the expression of two critical blood-brain barrier receptors required for amyloid-beta clearance to understand better the mechanism by which chronic stress impairs learning and memory in patients with Alzheimer's disease (AD). Rats were randomly assigned to one of two groups in this study: experiment 1 and experiment 2.

The medial prefrontal cortex to the medial amygdala connections may affect the anxiety level in aged rats.

Background: Aging changes brain function and behavior differently in male and female individuals. Changes in the medial prefrontal cortex (mPFC)-medial amygdala (MeA) connectivity affect anxiety-like behavior.

Objectives: Therefore, this study aimed to investigate the effect of aging and sex on the mPFC-MeA connection and its association with the level of anxiety-like behavior.

Compact, broadband, and low-loss multimode optical switch based on phase-change material for mode division multiplexing systems.

Mode-division multiplexing (MDM) technology is one of the suitable approaches to increase data transmission capacity in photonic integrated circuits. Multimode optical switches play an important role in MDM interconnection networks. In this article, we present a multimode on-off optical switch using phase-change material for the first two TE modes (TE0 and TE1) and the first two TM modes (TM0 and TM1) in a wide wavelength range between 100 nm to around 1550 nm.

Different paradigms of transcranial electrical stimulation improve motor function impairment and striatum tissue injuries in the collagenase-induced intracerebral hemorrhage rat model.

Background: In the horizon of therapeutic restrictions in intracerebral hemorrhage (ICH), recently, non-invasive transcranial electrical stimulation (tES) has achieved considerable prosperities. Translational studies have postulated that transcranial direct current stimulation (tDCS) and the other types of tES remain potentially a novel therapeutic option to reverse or stabilize cognitive and motor impairments.

Objective: The aim of this study was to comparatively evaluate the effects of the four main paradigms of tES, including tDCS, transcranial alternating (tACS), pulsed (tPCS), and random noise (tRNS) stimulations on collagenase-induced sensorimotor impairments and striatum tissue damage in male rats.

Ultracompact temporal integrator using graphene-based long-range hybrid plasmonic waveguides.

A microdisk-resonator add-drop temporal integrator, composed of a long-range hybrid plasmonic waveguide, with graphene as the central layer, is proposed for the first time, to the best of our knowledge. The integrator benefits from a considerable integration time of ∼5.55, which is about 11 times longer than our previously proposed plasmonic integrator, and also is fairly comparable with the integration time of a microring-based integrator with a ring radius of 47.

Simultaneous transcranial and transcutaneous spinal direct current stimulation to enhance athletic performance outcome in experienced boxers.

Transcranial direct current stimulation (tDCS) is among the rapidly growing experimental approaches to enhance athletic performance. Likewise, novel investigations have recently addressed the effects of transcutaneous spinal Direct Current Stimulation (tsDCS) on motor functions such as reduced reaction time. The impact of tDCS, and tsDCS might be attributed to altered spontaneous neural activity and membrane potentials of cortical and corticomotoneuronal cells, respectively.

Effect of nicorandil on the spatial arrangement of primary motor cortical neurons in the sub-acute phase of stroke in a rat model.

Introduction: Ischemic stroke remains a major cause of disability and death worldwide. The density and the spatial distribution of the primary motor (M1) cortical neurons are important in signal transmission and control the movement-related functions. Recently, the neuroprotective effect of nicorandil in cerebral ischemia was described through its anti-apoptosis, antioxidant and anti-inflammatory properties.

Treatment with edaravone improves the structure and functional changes in the hippocampus after chronic cerebral hypoperfusion in rat.

This study aimed to find out cellular and electrophysiological effects of the edaravone (EDR) administration following induction of vascular dementia (VaD) via bilateral-carotid vessel occlusion (2VO). The rats were randomly divided into control, sham, 2VO + V (vehicle), and 2VO + EDR groups. EDR was administered once a day from day 0-28 after surgery.

Effect of chronically electric foot shock stress on spatial memory and hippocampal blood brain barrier permeability.

Maintaining blood-brain barrier (BBB) contributes critically to preserving normal brain functions. According to the available evidence, intense or chronic exposure to stress would potentially affect different brain structures, such as the hippocampus, negatively. The purpose of this study was to define the relationship between the BBB permeability of the hippocampus and the performance of spatial learning and memory under chronically electric foot shock stress.

Insulin-Like Growth Factor 2 (IGF-2) Regulates Neuronal Density and IGF-2 Distribution Following Hippocampal Intracerebral Hemorrhage.

Background: The insulin-like growth factor 2 (IGF-2) is a growth factor and anti-inflammatory cytokine that plays a crucial role in memory consolidation. However, the precise role of this factor in acute brain damage is still unclear. The present study aimed to evaluate the variations in hippocampal IGF-2 distribution on different days and investigate the effect of recombinant IGF-2 on memory cell density, and IGF-2 distribution following acute hippocampal damage resulting from intracerebral hemorrhage (ICH).

Graphene-based plasmonic electro-optical SR flip-flop with an ultra-compact footprint.

In this paper, we present a new concept of electro-optical plasmonic Set-Reset flip-flops at mid-infrared frequencies. We use the 3D finite-difference time-domain (FDTD) method to simulate and evaluate our designed flip-flop. In the proposed structure, the propagation of surface plasmon polaritons is controlled by applying an electrostatic field and the switching actions occur in the electrical domain while the output signal is in the form of light.

Age-dependent changes in the medial prefrontal cortex and medial amygdala structure, and elevated plus-maze performance in the healthy male Wistar rats.

Aging affects different parts of the brain structure and function. These changes are associated with several age-related emotional alterations like anxiety that is regulated by the amygdala and medial prefrontal cortex (mPFC). Thus, this study aimed to explore the effects of aging on the morphology changes in these regions.

Ultra-broadband metamaterial absorber based on cross-shaped TiN resonators.

In this paper, a novel broadband plasmonic absorber based on cross-shaped titanium nitride (TiN) resonators in the ultraviolet, visible, and near-infrared regions is presented. The proposed perfect solar absorber consists of periodic arrays of cross-shaped TiN resonators located on a stack of ${{\rm SiO}_2}/{\rm TiN}$SiO/TiN layers. By using the finite-difference time-domain method, the effects of variations of the thickness and radius of the elliptical metasurface resonators on the absorption are comprehensively investigated.

Compact, high-performance, and fabrication friendly two-mode division multiplexer based on a silicon bent directional coupler.

In response to the increasing demands of the capacity enhancement of optical communication, a compact and high-performance silicon mode division multiplexer is proposed that multiplexes the fundamental and first-order transverse magnetic modes. The device structure is based on an asymmetric bent directional coupler with an ultrasmall coupling length of 3.67 µm.

Ultracompact and ultrabroadband mode division multiplexer based on an Au nanocube array assisted directional coupler.

An ultracompact and ultrabroadband two-mode (de)multiplexer based on an asymmetric directional coupler for mode division multiplexing is proposed. The device structure consists of a pair of silicon waveguides with an array of plasmonic Au nanocubes sandwiched in the coupling region. The coupling region length of the directional coupler is decreased to 1 µm for coupling of the fundamental transverse magnetic (TM) mode to the first order mode by excitation of the surface plasmon polaritons.

Compact and broadband 2 × 2 optical switch based on hybrid plasmonic waveguides and curved directional couplers.

In this paper, a compact, broadband, and CMOS compatible ${2} \times {2}$2×2 optical switch based on hybrid plasmonic waveguides (HPWs) and curved directional coupler is presented. The proposed coupler consists of a combination of straight and curved hybrid plasmonic waveguides. By using the ability of HPWs for confining the light wave in a sub-wavelength scale and the curved structure to decrease the wavelength dependence of the directional coupler, a 3 dB power splitter with a ${3}\,\,\textrm{dB} \pm 0.