Publications by authors named "Zarena Jafry"
Background & Aims: Hepatocellular carcinoma (HCC) risk persists in patients with chronic hepatitis B (CHB) despite antiviral therapy. The relationship between pre-treatment baseline hepatitis B virus (HBV) viral load and HCC risk during antiviral treatment remains uncertain.
Methods: This multinational cohort study aimed to investigate the association between baseline HBV viral load and on-treatment HCC risk in 20,826 noncirrhotic, hepatitis B e antigen (HBeAg)-positive and HBeAg-negative patients with baseline HBV DNA levels ≥2000 IU/mL (3.
Article Synopsis
- A study aimed to validate the link between baseline HBV viral load and the risk of developing hepatocellular carcinoma (HCC) in adults with chronic hepatitis B and without cirrhosis.
- The analysis involved 7,545 patients from Korea, Hong Kong, and Taiwan, and showed that 2.6% (200 patients) developed HCC during an average of 4.28 years of antiviral treatment.
- The findings indicated that higher baseline HBV viral loads (≥8.00 log 10 IU/mL) were associated with the lowest risk of HCC, while lower viral loads increased the risk significantly.
Background: Many individuals hospitalised with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection experience post-acute sequelae of SARS-CoV-2 infection (PASC), sometimes referred to as "long COVID". Our objective was to conduct a systematic literature review and meta-analysis to identify PASC-associated symptoms in previously hospitalised patients and determine the frequency and temporal nature of PASC.
Methods: Searches of MEDLINE, Embase, Cochrane Library (2019-2021), World Health Organization International Clinical Trials Registry Platform and reference lists were performed from November to December 2021.
Background: Children who live with a parent with a substance use disorder (SUD) are more likely to experience adverse health outcomes, including mental health disorders. We assessed whether residing with anyone who used substances was associated with children's anxiety and/or depression, and whether these associations differed by the children's age or sex.
Methods: We analyzed nationally representative cross-sectional data from the 2019 National Health Interview Survey (n = 6642).