Nitrogen catabolite repression (NCR) is a major transcriptional control pathway governing nitrogen use in yeast, with several hundred of target genes identified to date. Early and extensive studies on NCR led to the identification of the 4 GATA zinc finger transcription factors, but the primary mechanism initiating NCR is still unclear up till now. To identify novel players of NCR, we have undertaken a genetic screen in an NCR-relieved gdh1Δ mutant, which led to the identification of four genes directly linked to protein ubiquitylation.
View Article and Find Full Text PDFWe study the dissipation of the center of mass oscillation of a harmonically confined condensate in the presence of a disorder potential. An extension of the harmonic potential theorem allows one to formulate the dynamics from the point of view of an oscillating disorder potential. This formulation leads to a rigorous result for the damping rate in the limit of weak disorder.
View Article and Find Full Text PDFA case is presented of cardiac arrhythmia associated with varicella zoster infection, affecting a 34-year-old man. The patient presented with episodes of seizure-like activity, which were subsequently shown to be caused by ventricular fibrillation. The literature regarding this unusual complication of varicella zoster infection is discussed, as it affects both children and adults.
View Article and Find Full Text PDFWith the increasing recognition of pediatric sleep disorders, there is a growing demand for pediatric sleep medicine services, including polysomnography. The procedure of polysomnography can be particularly challenging in young children with limited ability to cooperate, especially when they have developmental disabilities or other medical complications. This article describes a family-centered care approach to polysomnography in children that is appropriate in any type of sleep laboratory setting.
View Article and Find Full Text PDFWe have performed self-consistent calculations of the nonlinear screening of a point charge Z in a two-dimensional electron gas using a density functional theory method. We find that the screened potential for a Z=1 charge supports a bound state even in the high-density limit where one might expect perturbation theory to apply. To explain this behavior, we prove a theorem to show that the results of linear response theory are in fact correct even though bound states exist.
View Article and Find Full Text PDFWe study transverse radial oscillations of an elongated Bose-Einstein condensate using finite-temperature simulations, in the context of a recent experiment at ENS [F. Chevy, Phys. Rev.
View Article and Find Full Text PDFFinite-temperature simulations are used to study quadrupole excitations of a trapped Bose-Einstein condensate. We focus specifically on the m = 0 mode, where a long-standing theoretical problem is to account for an anomalous variation of the mode frequency with temperature. We explain this behavior in terms of the excitation of two separate modes, corresponding to the coupled motion of the condensate and the thermal cloud.
View Article and Find Full Text PDFPhys Rev Lett
February 2002
We study surface modes of the condensate in the presence of a rotating thermal cloud in an axisymmetric trap. By considering collisions that transfer atoms between the condensate and the noncondensate, we find that m>0 modes, which rotate in the same sense as the thermal cloud, damp less strongly than m<0 modes, where m is the polarity of the excitation. We show that above a critical angular rotation frequency, equivalent to the Landau stability criterion, m>0 modes become dynamically unstable, leading to the possibility of vortex nucleation.
View Article and Find Full Text PDFPhys Rev Lett
September 2001
The dynamics of a trapped Bose-condensed gas at finite temperatures is described by a generalized Gross-Pitaevskii equation for the condensate order parameter and a semiclassical kinetic equation for the thermal cloud, solved using N-body simulations. The two components are coupled by mean fields as well as collisional processes that transfer atoms between the two. We use this scheme to investigate scissors modes in anisotropic traps as a function of temperature.
View Article and Find Full Text PDFThe usefulness of post operative serum CA 15-3 determination was evaluated in a group of 57 breast cancer patients. CA 15-3 was assayed at baseline and every 3 months for a median follow-up of 34 months. Recurrence-free survival probability for patients with elevated serum CA 15-3 levels before surgery was 53.
View Article and Find Full Text PDFLung cancers (squamous cell carcinoma, microcellular carcinoma, macrocellular carcinoma and adenocarcinoma) show procoagulant activity. It mainly depends on the presence of cancer procoagulant (CP) in lung cancer cells.
View Article and Find Full Text PDFActivity of cancer procoagulant (CP) was studied in blood serum of 90 patients with cancer of lung, breast, oesophagus and colorectum, and of 15 healthy people. The activity of CP was determined by the coagulation method. Sera of patients with cancer showed higher mean activity of CP than sera of healthy control.
View Article and Find Full Text PDFPhys Rev B Condens Matter
March 1994
Phys Rev B Condens Matter
June 1992
Phys Rev B Condens Matter
July 1991
Phys Rev B Condens Matter
April 1991
Patients with acute myocardial infarction show an increase of IgA and IgG, while IgM concentration showed no significant changes both at the onset and end of the disease. The level of circulating immune complexes increased essentially in patients with myocardial infarction; indomethacin furthers improvement of humoral and cellular immunity.
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