1,4-Benzodiazepine derivatives as anticonvulsant agents in DBA/2 mice.

1. The behavioural and anticonvulsant effects of 10 1,4-benzodiazepine derivatives were studied after intraperitoneal administration in DBA/2 mice, a strain genetically susceptible to sound-induced seizures. 2.

Ties between lexical and grammatical development: evidence from early-talkers.

Case studies are presented for two linguistically precious children (early-talkers) aged 1;9 and 1;5, one of whom represents a striking dissociation between vocabulary size and mean length of utterance. Each early-talker is compared to controls in the same language stage; 10 in Early State I (mean age 1;7) and 10 in Stage II (mean age 2;3). Data are explored to determine if the dissociation is best characterized as one between grammar and semantics, or a difference in cognitive style.

Computerized analysis of eye movements as a function of age.

Vertical and horizontal saccadic (SEMv, SEMh) and smooth pursuit eye movements (SPEM) were recorded in 66 normal subjects of different ages using a computerized system. No difference was found in SEMh recordings for the right versus the left eye or for gaze direction. In contrast, SEMv recordings of upgaze vs.

Sequential occurrence of benign partial epilepsy and childhood absence epilepsy in three patients.

We first report 3 patients who experienced absence epilepsy (mean age at onset: 6.3 years; range: 4-9) 1-4 years after recovering from an electroclinical picture characteristic of benign childhood partial epilepsy (BCPE). All patients were put on monotherapy with sodium valproate, and their long-term course was excellent with remission of absences and normalization of EEG recordings.

Autosomal recessive hereditary motor and sensory neuropathy with focally folded myelin sheaths: clinical, electrophysiologic, and genetic aspects of a large family.

We describe 10 patients from a large family with early onset motor and sensory neuropathy. Six were still living at the time of the study. In all cases, early motor milestones had been achieved.

Photic-induced epileptic negative myoclonus: a case report.

We present the first documented case of photic-induced epileptic negative myoclonus. A 17-year-old girl had experienced two generalized tonic-clonic seizures (GTCS) while watching television. The only EEG abnormality was a photoparoxysmal response (PPR), which was sometimes accompanied by loss of postural tone in both arms.

Brain-stem auditory evoked potentials (BAEPs) from basal surface of temporal lobe recorded from chronic subdural electrodes.

BAEPs were recorded from the basal surface of the temporal lobe by subdural electrodes chronically implanted in 6 patients who were evaluated for surgical management of intractable partial seizures. Near-field recordings were obtained by recording between the subdural electrode closest and most distant to the brain-stem. Far-field recordings were obtained by recording between the subdural electrodes and an indifferent electrode over the spinal process of the seventh cervical vertebrae.

Functional preservation of benzodiazepine receptors of the primary somatosensory cortex in Creutzfeldt-Jakob disease: a pharmacologic-evoked potential study.

In previous studies, we demonstrated that the benzodiazepine (BZP) receptors of the visual system are functionally preserved in Creutzfeldt-Jakob disease (CJD). We hypothesized that such a functional preservation is not confined to the visual system. In a 74-year-old woman suffering from CJD, three consecutive recording sessions of somatosensory cortical evoked potentials (SEPs) by right median nerve stimulation were carried out: (a) basal condition, without any pharmacologic treatment; (b) 1 min after i.

De novo epileptic confusional status in a patient with cobalamin deficiency.

A 80-year-old man with cobalamin deficiency and no history of epilepsy developed a partial complex epileptic confusional status (ECS) unresponsive to acute i.v. diazepam.

The subacute levodopa test for evaluating long-duration response in Parkinson's disease.

The clinical relevance of a long-duration response (LDR) to levodopa therapy in Parkinson's disease (PD) has not been widely recognized. In 25 patients with moderate PD, we measured LDR on motor function after short periods of treatment with levodopa (subacute tests). Each subacute test lasted 15 days and consisted of the oral administration of levodopa at various interdose intervals (IDIs) of 48, 24, 12, 8, 6, and 5 hours.

Negative myoclonus during valproate-related stupor. Neurophysiological evidence of a cortical non-epileptic origin.

We retrospectively reviewed clinical and neurophysiological data of 6 epileptic patients who developed negative myoclonus and stupor a few days after introduction of valproate (VPA). Prompt remission of clinical signs and symptoms followed valproate withdrawal. We attempted to elucidate the pathophysiological mechanism of VPA-induced stupor and provide further polygraphic and backaveraging EEG documentation of negative myoclonus.

Chlorpromazine versus sleep deprivation in activation of EEG in adult-onset partial epilepsy.

We prospectively compared the activating effect of chlorpromazine (CHLP, 50 mg, i.m.) versus sleep deprivation (SD) in 41 patients with a clinical diagnosis of partial epilepsy.

Usefulness of movement time in the assessment of Parkinson's disease.

Reaction time (RT) and movement time (MT) are reported to be delayed in Parkinson's disease (PD), but their clinical utility and relationship with clinical findings is still uncertain. We investigated RT and MT in 22 PD patients at baseline conditions and following acute oral trials of levodopa and biperiden, an anticholinergic drug. At baseline conditions, RT and MT of PD patients were abnormally delayed compared with those of 16 normal control subjects.

Oral pulse levodopa therapy in mild Parkinson's disease.

Chronic levodopa administration in Parkinson's disease (PD) is associated with long-term motor side effects. To reduce the cumulative amount of levodopa intake by patients with mild PD, we investigated the clinical efficacy of short periods of treatment with levodopa scheduled at different daily dosages and administered in a conventional design (ie, three times a day) compared with a standard oral dose of the drug administered once every 3 days. The latter dose regimen, designated "oral pulse levodopa therapy" (OPLT), allowed us to obtain a clinical response comparable to that obtained by conventional treatments that involve cumulative daily levodopa dosages up to seven times higher than OPLT.

F-wave normative studies in different nerves of healthy subjects.

F-wave main characteristics were investigated following stimulation of 8 different nerves (facial, axillary, radial, median, ulnar, femoral, deep peroneal, posterior tibial) in a population of normal healthy subjects. Additional studies compared different stimulation and recording techniques (stimulus intensity, stimulus duration, number of consecutive stimuli, facilitating maneuvers, type of recording electrodes). F-wave persistency varied markedly among the different nerves.

Symptomatic tension pneumocephalus after evacuation of chronic subdural haematoma: report of seven cases.

We present seven cases of tension pneumocephalus developing after burr hole evacuation of chronic subdural haematoma. After a careful review of the literature we discuss the physiopathology, the diagnosis and the treatment of this complication of chronic subdural haematoma surgery.

Combined neurophysiological studies in Creutzfeldt-Jakob disease: a case report.

EEG and brain mapping (on basal conditions and after i.v. administration of diazepam) and visual, somatosensory and auditory evoked potentials have been performed on a patient at terminal evolution of CJD.

Carbamazepine-induced nonepileptic myoclonus in a child with benign epilepsy.

Myoclonic jerks involving the proximal limb musculature and tic-like movements (sniffing, coughing, or sighing) were observed in an 11-year-old boy with benign occipital epilepsy treated with carbamazepine (CBZ). The involuntary movements disappeared a few days after withdrawal of CBZ and reappeared with CBZ reintroduction. Plasma CBZ levels were always within the therapeutic range.

Diurnal fluctuations of human nerve conduction velocity.

In 14 normal subjects, sensory conduction velocity (SCV), determined at constant skin temperature, displayed diurnal fluctuations which were related to similar variations in rectal temperature. Control of surface limb temperature in routine EMG does not completely obviate the variations induced by the body temperature cycle. Diurnal fluctuations should be taken into account when performing serial CV determinations in the same individual.

Gowers local panatrophy.

Gowers local panatrophy is a rare disease of skin, subcutaneous and muscular tissues, occurring multifocally and related to the syndromes of congenital or acquired lipodystrophy, although it presents similarities with other connective tissue disorders such as scleroderma. We report here the clinical and electromyographic findings in two patients with local panatrophy and emphasize its benign course and its similarity to scleroderma circumscripta.