Publications by authors named "Zappa M"
Background And Study Aims: Removal of cocaine pellets by endoscopy is the subject of much debate, due to the supposed risk of rupture. This study aimed to evaluate the safety of digestive endoscopic removal of cocaine pellets.
Patients And Methods: This was a single-center, observational, retrospective study conducted at the Cayenne Hospital in French Guiana from July 2015 to May 2023.
The effect of benralizumab on inflammation in severe asthma: a real-life analysis.
Ther Adv Respir Dis
December 2024
Background: Benralizumab is a monoclonal antibody treatment for severe eosinophilic asthma (SEA). Few studies investigated its role in airway inflammation and its correlation with lung function.
Objectives: The aim of the present study is to assess its effect after 1 year of treatment, focusing on airway inflammation.
Ultrasound-guided Transversus Abdominis Plane Block (UG-TAPB) reduces post-operative pain better than i.v. painkillers in patients operated with laparoscopic surgery.
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- * A study involving nearly 2,000 non-resectable HCC patients showed that LMWA had comparable safety and overall survival rates to PRFA and significantly better survival rates than TACE after 1, 3, and 5 years.
- * The results suggest that LMWA is a viable treatment option for early HCC, outperforming TACE while demonstrating similar efficacy to PRFA, which supports its potential inclusion in standardized treatment
Article Synopsis
- A guideline panel in Italy created recommendations for breast cancer screening to align with European Breast Cancer Guidelines, following the ADOLOPMENT approach for adaptation.
- The panel utilized the GRADE EtD framework, incorporating findings from a PubMed search specific to Italy, and included nine articles as contextual evidence.
- Thirteen finalized recommendations emphasize organized screening every 2 years for women aged 50-69, conditional screening for those aged 70-74, and advise against annual mammography for women 50 and older to enhance standardized processes and promote health equity.
Introduction: Asthma is a chronic inflammatory respiratory disease often associated with comorbidities. Among cardiovascular comorbidities, arterial hypertension seems to create an additional health burden in asthmatics. However, evidence on this relationship is lacking.
View Article and Find Full Text PDFObesity is a chronic disease associated with increased morbidity and mortality and reduced quality of life. Pharmacotherapy can be associated with life style changes in increasing and maintaining weight loss and ameliorating obesity-related complications and comorbidities. In patients affected by obesity and uncontrolled obesity-associated complications or high degrees of BMI (> 40 Kg/m), metabolic bariatric surgery can be a valid therapeutic option.
View Article and Find Full Text PDFThe 2022 American Society for Metabolic and Bariatric Surgery (ASMBS) and International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) updated the indications for metabolic and bariatric surgery (MBS), replacing the previous guidelines established by the National Institutes of Health (NIH) over 30 years ago. The evidence supporting these updated guidelines has been strengthened to assist metabolic and bariatric surgeons, nutritionists, and other members of multidisciplinary teams (MDTs), as well as patients. This study aims to assess the level of evidence and the strength of recommendations compared to the previously published criteria.
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- The text addresses a correction related to the article identified by the DOI 10.3389/fpsyt.2024.1369720.!* -
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The escalating global prevalence of bariatric procedures necessitates an enhanced focus on optimizing perioperative care for improved patient outcomes. This study focuses on the implementation of Enhanced Recovery After Bariatric Surgery (ERABS) protocols in Italian bariatric centers to optimize perioperative care. An online survey comprising 19 items was conducted in October 2023, targeting managing surgeons in 139 registered bariatric centers.
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- The ASMBS and IFSO updated the guidelines for Metabolic and Bariatric Surgery in 2022, replacing 30-year-old NIH recommendations.
- These new guidelines are based on stronger evidence and are designed to support healthcare professionals and patients in making informed decisions about surgery.
- The study evaluates the quality of evidence and the effectiveness of these updated recommendations compared to the old criteria.
Article Synopsis
- * In children, causes of secondary hypertension typically include aortic issues or genetic mutations, while in adults, it can stem from conditions like atherosclerosis or hormonal disorders.
- * Secondary hypertension should be suspected in younger patients, those with treatment-resistant or severe hypertension, rapid increases in blood pressure, and patients showing signs of certain endocrine disorders or sleep apnea.
Climate model ensembles serve as an input to all impact studies that use sector-specific models (e.g., hydrological, ecological, crop models, fire hazard) at regional or local scales.
View Article and Find Full Text PDFPurpose: This study quantifies the impact on budget and cost per health benefit of implementing digital breast tomosynthesis (DBT) in place of digital mammography (DM) for breast cancer screening among asymptomatic women in Italy.
Methods: A budget impact analysis and a cost consequence analysis were conducted using parameters from the MAITA project and literature. The study considered four scenarios for DBT implementation, i.
Article Synopsis
- The 2023 SFR data challenge aimed to encourage researchers to create AI models for detecting pancreatic masses and determining if they are benign or malignant using abdominal CT scans.
- A total of 1,037 CT examinations were gathered from 18 French centers, organized into training and evaluation sets, with teams composed of radiologists, data scientists, and engineers participating in the analysis.
- The challenge involved 10 teams and showed promising results, with AI demonstrating potential in identifying pancreatic lesions from real data, although distinguishing between benign and malignant masses remains challenging.
Purpose: We present a comprehensive investigation into the organizational, social, and ethical impact of implementing digital breast tomosynthesis (DBT) as a primary test for breast cancer screening in Italy. The analyses aimed to assess the feasibility of DBT specifically for all women aged 45-74, women aged 45-49 only, or those with dense breasts only.
Methods: Questions were framed according to the European Network of Health Technology Assessment (EuNetHTA) Screening Core Model to produce evidence for the resources, equity, acceptability, and feasibility domains of the Grading of Recommendations Assessment, Development and Evaluation (GRADE) decision framework.
Introduction: Sickle cell disease (SCD) is a genetic disorder with a high infectious morbidity and mortality and a heterogeneous distribution in France. One of the challenges is to differentiate a bone and joint infection (BJI) from a vaso-occlusive crisis. This challenge is particularly prevalent in French Guiana, an overseas territory with the highest incidence of SCD in France.
View Article and Find Full Text PDFObesity/overweight and its complications are a growing problem in many countries. Italian Society of Bariatric and Metabolic Surgery for Obesity (Società Italiana di Chirurgia dell'Obesità e delle Malattie Metaboliche-SICOB) decided to develop the first Italian guidelines for the endoscopic bariatric treatment of obesity. The creation of SICOB Guidelines is based on an extended work made by a panel of 44 members and a coordinator.
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- The study explores the effectiveness of total plasma cell-free DNA (cfDNA) in distinguishing between malignant and benign lung nodules seen in low-dose computed tomography (LDCT) for lung cancer screening.
- Researchers measured cfDNA levels in 137 subjects, including those with confirmed lung cancer (LC) and benign nodules, and compared its predictive value to existing assessment tools like Lung-RADS and Brock score.
- Findings revealed that high cfDNA levels were significantly more common in patients with lung cancer, suggesting that increased cfDNA could serve as a valuable marker for differentiating between malignant and benign nodules in LDCT screenings.
Background: Bacterial peritonitis (BP) in patients with gastrointestinal (GI) cancer has been poorly described, and its prevalence is unknown.
Objectives: This study aimed to evaluate in patients with both GI cancer and ascites the prevalence of BP, associated features, mechanisms, prognosis, and the diagnostic performance of neutrophil count in ascites.
Design: A retrospective, multicenter, observational study.
Article Synopsis
- - Benralizumab effectively manages severe eosinophilic asthma (SEA), showing a significant 89% reduction in exacerbation rates and a 440 mL increase in forced expiratory volume (FEV) over 36 months in a study of 108 Italian patients.
- - The treatment led to notable improvements in asthma control and sinonasal symptoms for patients with chronic rhinosinusitis with nasal polyposis, with 84.31% achieving partial or complete clinical remission.
- - Results indicate benralizumab may act as a long-term disease-modifying drug for SEA, with most patients able to reduce or stop their oral corticosteroids, but further research is needed to evaluate its long-term safety and effectiveness.
Article Synopsis
- - Arterial hypertension is a worldwide issue affecting 1.28 billion adults and is a major cause of cardiovascular problems and deaths, with 7.1 million fatalities linked to it each year.
- - It is influenced by both genetic and environmental factors, and researchers are making significant progress in understanding its molecular genetic basis, having identified over 900 genomic locations related to blood pressure regulation.
- - Understanding these genetic mechanisms could help identify individuals at risk for hypertension and lead to new drugs and tailored treatment options.
Article Synopsis
- Normal-weight individuals with asthma often engage in less physical activity, and this study aimed to assess the impact of a pulmonary rehabilitation program on their daily activity levels.
- The feasibility study involved 17 participants wearing accelerometers to measure their steps and activity time before and after the program, with usable data from 16 participants ultimately analyzed.
- Results showed a modest increase in daily steps and a slight decrease in activity time post-rehabilitation, while also noting improvements in quality of life, muscle strength, and exercise capacity.
Article Synopsis
- High blood eosinophils in COPD patients may indicate how well they respond to inhaled corticosteroids (ICS) treatment, but this study focused on those treated only with bronchodilators for two years.
- The study monitored 63 COPD patients' lung function, blood and sputum eosinophils, and exacerbations every six months, finding that after two years, 29% of patients needed to add ICS due to worsening symptoms.
- Despite some patients receiving ICS, blood and sputum eosinophil levels remained stable and did not correlate with exacerbations, though a history of ischemic heart disease was linked to increased blood eosinophils over time.
Article Synopsis
- Mindfulness interventions can enhance various patient outcomes, but traditional methods are often lengthy and resource-heavy.
- Recent studies suggest that shorter mindfulness sessions can be effective and easily integrated into medical settings without causing major disruptions.
- Three pilot randomized controlled trials showed that brief audio recordings of mindfulness significantly reduced pain intensity in clinic waiting rooms, as well as lower anxiety symptoms, with implications for improving patient care.