A novel class of Cd(II), Hg(II) turn-on and Cu(II), Zn(II) turn-off Schiff base fluorescent probes.

N,N'-((5,5'-(quinoxaline-2,3-diyl)bis(1H-pyrrole-5,2-diyl))bis(methanylylidene))bis(4-methoxyaniline) 4 and N,N'-((5,5'-(quinoxaline-2,3-diyl)-bis(1H-pyrrole-5,2-diyl))bis(methanylylidene))dianiline 5 have been prepared and structurally characterized. The X-ray crystal structures of compounds 4 and 4a have been determined. These compounds displayed good sensitivity toward transition metal ions with Cd(II), Zn(II) turn-on and Cu(II), Hg(II) turn-off in fluorescence.

Synthesis and in vitro and in vivo evaluation of manganese(III) porphyrin-dextran as a novel MRI contrast agent.

5-(4-Aminophenyl)-10,15,20-tris(4-sulfonatophenyl) manganese(III) porphyrin conjugated with dextran was synthesized. Its potential of being used as a tumor-targeting magnetic resonance imaging contrast agent was evaluated in vitro and in vivo. The results demonstrated that the compound has a longitudinal relaxivity (R(1)) higher than Gd-DTPA, low cytotoxicity and binding specificity to tumor cell membrane.

Synthesis of dendritic stationary phases with surface-bonded L-phenylalanine derivate as chiral selector and their evaluation in HPLC resolution of racemic compounds.

Four dendrimers were synthesized on aminopropyl-modified silica gel using methyl acrylate and ethylene diamine as building blocks by divergent method. Four generations of chiral stationary phases (CSPs) were prepared by coupling of L-2-(p-toluenesulfonamido)-3-phenylpropionyl chloride to corresponding dendrimers. The derivatives prepared on silica gel were characterized by FT-IR, (1)H NMR, and elemental analysis.

Synthesis, and DNA-binding and DNA-photocleavage properties of multiply charged porphyrins.

Four new cationic porphyrins, compounds 1-4, with five to seven positive charges, were synthesized, characterized, and investigated for their binding properties towards calf-thymus DNA (CT-DNA). UV/VIS and fluorescence-titration data indicated strong binding, the apparent binding constants (K(app); (1.3-10)x10(-6) M) increasing with increasing number of charges, as determined by competitive fluorescence titration using ethidium bromide (EB) as molecular probe.

Binding and photocleavage of cationic porphyrin-phenylpiperazine hybrids to DNA.

The binding properties of cationic porphyrin-phenylpiperazine hybrids to calf thymus (CT) DNA were investigated by using absorption, fluorescence and circular dichroism (CD) spectra, and the apparent affinity binding constants (K(app)) of the porphyrins for CT DNA were determined by using a competition method with ethidium bromide (EB). Intercalation of porphyrin into CT DNA occurred when two phenylpiperazines were introduced at cis position onto the periphery of cationic porphyrin. The photocleavages of pBR322 plasmid DNA by the porphyrins were consistent with the values of K(app).

Dipyrrolylquinoxaline-bridged Schiff bases: a new class of fluorescent sensors for mercury(II).

Novel 2,3-bis(1H-pyrrol-2-yl)quinoxaline-functionalized Schiff bases were prepared and characterized as new fluorescent sensors for mercury(II) ion. The X-ray crystal structures of compounds 4, 5, 4a and 5a were determined. The binding properties of 4 and 5 for cations were examined by UV-vis and fluorescence spectroscopy.

[Effect of photodynamic therapy with metalloporphyrin compound on human prostate cancer PC-3 cells in vitro].

Objective: To investigate the effect of the photodynamic therapy (PDT) with the new water-soluble metalloporphyrin compound on human prostate cancer PC-3 cells in vitro and the anticancer mechanism of PDT.

Methods: The new water-soluble manganese, 5,10,15, 20-tetra (N-methyl4-pyridyl) porphinato (2-) tetraiodide salt, was synthesized. The PC-3 cells were treated with the compound of serial concentrations(0, 0.

[Synthesis and anti-active oxygen properties of water-soluble metal porphyrins].

Aim: To synthesize four water-soluble metal porphyrins [5, 10, 15, 20-tetra[4-(4'-pyridine-1) butyloxy phenyl] metalloporphyrins bromide, metal = Zn (I), Cu (II), Mn (III) and Co (IV)] as analogous enzyme having two anti-active oxygen functions.

Methods: The first function, scavenging O2-, has been proved by using riboflavine-methionine photoreduction methods. The second function, scavenging H2O2, has been demonstrated by using the oxidating Vit C.

Synthesis of Bis(aliphatic amine)osmium(II), Bis(arylamido)osmium(IV), and Bis(imido)- and Oxo(imido)osmium(VI) Porphyrins.

The syntheses, characterization, and reactivity of a series of osmium porphyrins, Os(II)(Por)(H(2)NR)(2) [Por = dianions of octaethylporphyrinato (OEP), tetraphenylporphyrinato (TPP), meso-tetrakis(p-tolyl)porphyrinato (TTP), meso-tetrakis(4-chlorophenyl)porphyrinato (4-Cl-TPP), meso-tetrakis(3,4,5-trimethoxyphenyl)porphyrinato (3,4,5-MeO-TPP), R = (t)Bu; Por = TPP, R = (i)Pr], Os(II)(Por)(HNEt(2))(2) (Por = TPP, 3,4,5-MeO-TPP), Os(IV)(Por)(NHAr)(2) (Por = OEP, TPP, 3,4,5-MeO-TPP; Ar = Ph, 4-F-Ph), Os(VI)(Por)(N(t)Bu)(2) (Por = TPP, TTP, 4-Cl-TPP, 3,4,5-MeO-TPP), Os(VI)O(Por)(N(t)Bu) (Por = TPP, TTP, 4-Cl-TPP, 3,4,5-MeO-TPP), and Os(VI)O(Por)(4-F-PhN) (Por = TPP, 3,4,5-MeO-TPP) are described. The complexes Os(Por)(HNAr)(2) are prepared from the reactions of Os(Por)(N(2))(THF) with arylamines in aerobic tetrahydrofuran. Air oxidations of Os(Por)(H(2)N(t)Bu)(2) in tetrahydrofuran and in the presence of H(2)N(t)Bu give OsO(Por)(N(t)Bu) and Os(Por)(N(t)Bu)(2).