[A comparative analysis of the antihypertensive activity of calcium antagonists and adrenoblockers in long-term treatment].

Essential hypertension stage II was treated by calcium antagonists, alpha- and beta-adrenoblockers in 362 patients. The drugs were compared for hypotensive efficiency at rest and exercise. A significant hypotensive effect was achieved in 81%, 58%, 44%, 43% and 37% of patients treated with labetalol, nifedipine, nadolol, propranolol, diltiazem, respectively.

[The efficacy of a 4-year course of drug treatment for patients with juvenile hypertension].

To evaluate the hypotensive efficacy and effects of some hypotensive drugs on the hemodynamics and concentration of testosterone in its blood plasma the authors examined 205 patients with juvenile hypertension (JH): main group--134 patients; comparison group--71 patients). Course treatment (1.5-2 months) with obsidan, niphedipin, verapamyl was carried out with nondrug treatment during intervals.

[The indices of the cerebral hemodynamics in patients with juvenile hypertension and different types of blood circulation].

A study of 100 patients with juvenile hypertension (JH) revealed a dependence between the character of changes of the cerebral vessel tone and type of central hemodynamics (TCH). Patients with the hypokinetic TCH show more frequently the vasospastic form of cerebral circulation (FCC) while the vasodilation FCC was observed rarer. The vasodilation FCC prevailed in patients with hyperkinetic TCH while the vasospastic was not observed.

[Radionuclide ventriculography in assessing left ventricular contractile function in patients with I-stage hypertension].

The general and local ejection fractions (EF) of the left ventricle were studied in 112 patients with grade I hypertensive disease and in 20 practically healthy persons at rest and during static isometric loads. At rest general and local EF were diverse. During loads both reduction and increase of general EF were observed.

[Effect of the treatment on hemodynamic indicators and plasma testosterone level in patients with juvenile hypertension].

The effect of anapriline, corinfar and reserpine on parameters of hemodynamics and plasma testosterone was evaluated in 60 juvenile hypertension patients who achieved pronounced hypotensive response. It was established that the level of sex hormones tended to diminution by the end of the treatment month 1 or 2, this drop being more noticeable in reserpine administration. Basing on this evidence it would be beneficial for patients suffering from juvenile hypertension in need of chemotherapy to take courses of the above drugs.

[The long-term use of obzidan in patients with hypertension].

The state of 48 patients with hypertensive disease was studied before and in the course of prolonged anaprilin monotherapy. Most patients with an initially increased mass of left ventricle myocardium (MLVM) showed beginning with the third month a reduction of this mass due to decrease in the thickness of the posterior wall and interventricular septum accompanied by an increased tolerance of the patients to physical load.

[Difficulties and errors in the differential diagnosis of arterial hypertension].

The authors analyzed 255 case records of patients with symptomatic arterial hypertension treated in the Clinics of the Kiev Research Institute of Cardiology in 1985-1986 with the purpose of differential diagnosis of AH on the out-patient stage. It is concluded that the outpatient level of diagnosis was insufficient mainly due to the subjective character.

[Effect of obzidan on hemodynamic indices and the renin and aldosterone levels of the blood plasma in patients with juvenile hypertension].

Hemodynamic and humoral indices were studied in patients with juvenile hypertension before and after a months treatment course with obsidan. The beginning of the disease was in 18% distinguished by an increased thickness of the wall and interventricular septum. Obsidan treatment (0.

[Relation between the renin-angiotensin and kallikrein-kinin systems of the blood during physical loading of hypertension patients].

Blood angiotensin-converting enzyme, renin, kallikrein and prekallikrein ratios were investigated in 61 essentially hypertensive patients at rest and during rationed exercise. Biochemical findings were compared with major parameters of systemic hemodynamics measured under the same conditions. Grouping of patients on the basis of renin activity was mirrored in different levels of the angiotensin-converting enzyme and kallikrein: increased renin activity was accompanied by the activation of the said enzymes, and reduced activity, by their suppression.