Publications by authors named "Zanovello A"
Background: ERAS is an evidence-based multimodal perioperative protocol focused on stress reduction and promoting a return to function. The aim of this work is to perform a cost-consequence analysis for the implementation of ERAS in major lung resection by means of minimally invasive surgery (VATS) from the public health service perspective, evaluating resource consumption and clinical outcomes with respect to a control group of past patients, which did not adopt an ERAS protocol.
Methods: Outcome differences (re-intervention rates, major and minor intraoperative and postoperative complications, readmissions, and mortality) as well as the costs of preoperative, operative, and postoperative care were estimated.
Background: Increased screen time in children is significantly associated with lower adherence to the Mediterranean diet (MD). The purpose of this study was to explore the association between different types of media use and the adherence to the MD in children.
Methods: The study sample included 332 children aged 10-11 years attending the fifth year of primary school in Veneto, north-east Italy.
Article Synopsis
- Cutaneous malignant melanoma (CMM) is a common cancer among young people in wealthy countries, but there's limited research on its care quality and costs for adolescents and young adults (AYA).
- The study analyzed 2,435 CMM cases from a cancer registry in Italy, focusing on factors like age, clinical features, survival rates, and care costs.
- Findings revealed rising CMM incidence among AYAs, with males typically having less advanced cases, and those aged 15-39 showed better overall survival compared to older adults; however, care costs for AYAs were significantly lower.
Background: In industrialized countries, the aging population is steadily rising. The incidence of cutaneous malignant melanoma (CMM) is highest in old people. This study focuses on the clinicopathological profile of CMM and indicators of diagnostic-therapeutic performance in older patients.
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- The study explores the rising costs of care for melanoma patients, driven by increased disease incidence and new treatments, using data from 2,647 cases registered in the Veneto Cancer Registry.
- Average direct costs per patient peak in the first year post-diagnosis (€2,903), primarily due to high hospitalization costs, which are significantly reduced in subsequent years; outpatient and drug costs also decrease over time.
- Findings suggest that understanding costs by tumor characteristics can help in managing expenses related to melanoma care, highlighting the need for policy makers to consider stage-specific costs for resource allocation.
The development of laser powder bed fusion (LPBF) additive manufacturing techniques for microfabrication raises the need for the employment of new process configurations and parameters. In this study, micro-LPBF of Ni-based superalloy Inconel 718 using a spot laser of 30 µm was examined. The response surface method with a central composite design was employed to determine the optimum process parameter.
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- The study examined how trifluoroacetylated (TFA)-protein adducts in guinea pigs relate to liver damage after exposure to halothane or HCFC-123, a chlorofluorocarbon replacement.
- After administering various doses of HCFC-123 or halothane, TFA-proteins were found in liver and plasma samples, indicating potential liver injury.
- Interestingly, while liver damage was noted even at lower doses of HCFC-123, the presence of TFA-proteins in plasma appeared only at higher doses, suggesting a complex relationship between liver damage and TFA-protein levels in the bloodstream.
The bioactivation and cytotoxicity in vitro of 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123) and 1,1-dichloro-1-fluoroethane (HCFC-141b), two replacements for some ozone-depleting chlorofluorocarbons (CFC), were investigated in rat liver microsomes and isolated rat hepatocytes. Both compounds were activated by cytochrome P450 to reactive metabolites, as indicated by: (i) the depletion of exogenous and cellular glutathione, (ii) the increased LDH release from hepatocytes, (iii) the loss of microsomal P450 content and activities, and (iv) the formation of free radical species observed in the presence of the two compounds. Moreover, the formation of two stable metabolites and an increased production of conjugated dienes, a marker of lipid peroxidation, were observed for both HCFC-123 and HCFC-141b.
View Article and Find Full Text PDFN,N-dimethylformamide (DMF), an organic solvent widely used in industry, is bioactivated by cytochrome P450 (P450) to reactive metabolites which are believed to be responsible for the hepatotoxicity observed in animals and humans. A decrease of the activating enzyme has been reported in rats treated with DMF, although the specific P450 isoform(s) involved and the nature of the reactive species responsible for this and the other toxic effects are still being investigated. In the present work, the effect of DMF and of the structurally related N,N-dimethylacetamide (DMAc) on the activating enzyme and the nature of the reactive species involved in the mechanism of P450 inactivation by the two chemicals were investigated in vitro.
View Article and Find Full Text PDF1. The in vitro bioactivation by rat liver microsomes and the cytotoxicity in rat hepatocytes of 1,1-dichloro-1-fluoroethane (HCFC-141b), a replacement for some ozone depleting chlorofluorocarbons (CFC), have been investigated. 2.
View Article and Find Full Text PDFThe bioactivation and cytotoxicity of 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123), a replacement for some ozone-depleting chlorofluorocarbons, were investigated using freshly isolated hepatocytes from non-induced male rats. A time- and concentration-dependent increase in the leakage of lactate dehydrogenase and a concentration-dependent loss of total cellular glutathione were observed in cells incubated with 1, 5 and 10 mM HCFC-123 under normoxic or hypoxic (about 4% O2) conditions. Lactate dehydrogenase leakage was completely prevented by pretreating the cell suspension with the free radical trapper N-t-butyl-alpha-phenylnitrone.
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