"Outlier detection: Underused in sport science despite outliers' impact on inference and prediction".

Outlier detection is critical in statistical analysis and predictive modelling, but it is often overlooked in research, leading to potentially inaccurate conclusions. This study aimed to (1) assess the prevalence of outlier detection strategies in sport science publications, (2) examine the effect of outliers on statistical inference using general linear mixed-effects models with longitudinal data, and (3) evaluate the impact of outliers on regression predictive models using the same dataset. A systematic literature search of 4,622 articles published in 2023 in Q1 journals in "sport science" category found that only 9.

Effects of deforestation on multitaxa community similarity in the Brazilian Atlantic Forest.

Habitat loss can lead to biotic homogenization (decrease in β diversity) or differentiation (increase in β diversity) of biological communities. However, it is unclear which of these ecological processes predominates in human-modified landscapes. We used data on vertebrates, invertebrates, and plants to quantify β diversity based on species occurrence and abundance among communities in 1367 landscapes with varying amounts of habitat (<30%, 30-60%, or >60% of forest cover) throughout the Brazilian Atlantic Forest.

Lung-Protective Mechanical Ventilation in Patients with Severe Acute Brain Injury: A Multicenter Randomized Clinical Trial (PROLABI).

Lung-protective strategies using low Vt and moderate positive end-expiratory pressure (PEEP) are considered best practice in critical care, but interventional trials have never been conducted in patients with acute brain injuries because of concerns about carbon dioxide control and the effect of PEEP on cerebral hemodynamics. To test the hypothesis that ventilation with lower VT and higher PEEP compared to conventional ventilation would improve clinical outcomes in patients with acute brain injury. In this multicenter, open-label, controlled clinical trial, 190 adult patients with acute brain injury were assigned to receive either a lung-protective or a conventional ventilatory strategy.

Occupational Exposure to 50 ppm Isoflurane Impairs Sperm Parameters in Mice.

Objectives: The aims of the study are to assess the effect of occupational exposure to isoflurane on the sperm quality of mice and to investigate whether cessation of exposure can restore seminal quality.

Methods: Mice were exposed to 50 ppm of isoflurane for 5 hours per day over a 30-day period. Following this exposure, they were euthanized at predetermined postexposure intervals, and their sperm samples were analyzed for kinetics and viability parameters.

Effect of uneven tolerance to human disturbance on dominance interactions of top predators.

Anthropogenic activities may alter felid assemblage structure, facilitating the persistence of tolerant species (commonly mesopredators), excluding ecologically demanding ones (top predators) and, consequently, changing coexistence rules. We aimed to determine how human activities influence intraguild relationships among top predators and their cascading effects on mesopredators, which remain poorly understood despite evidence of top carnivore decline. We used structural equation modeling at a continental scale to investigate how habitat quality and quantity, livestock density, and other human pressures modified the intraguild relations of the 3 species that are at the top of the food chain in the Neotropics: jaguars (Panthera onca), pumas (Puma concolor), and ocelots (Leopardus pardalis).

A(H2N2) and A(H3N2) influenza pandemics elicited durable cross-reactive and protective antibodies against avian N2 neuraminidases.

Human cases of avian influenza virus (AIV) infections are associated with an age-specific disease burden. As the influenza virus N2 neuraminidase (NA) gene was introduced from avian sources during the 1957 pandemic, we investigate the reactivity of N2 antibodies against A(H9N2) AIVs. Serosurvey of healthy individuals reveal the highest rates of AIV N2 antibodies in individuals aged ≥65 years.

How representative are air transport functional complex networks? A quantitative validation.

Functional networks have emerged as powerful instruments to characterize the propagation of information in complex systems, with applications ranging from neuroscience to climate and air transport. In spite of their success, reliable methods for validating the resulting structures are still missing, forcing the community to resort to expert knowledge or simplified models of the system's dynamics. We here propose the use of a real-world problem, involving the reconstruction of the structure of flights in the US air transport system from the activity of individual airports, as a way to explore the limits of such an approach.

Reconstructing brain functional networks through identifiability and deep learning.

We propose a novel approach for the reconstruction of functional networks representing brain dynamics based on the idea that the coparticipation of two brain regions in a common cognitive task should result in a drop in their identifiability, or in the uniqueness of their dynamics. This identifiability is estimated through the score obtained by deep learning models in supervised classification tasks and therefore requires no a priori assumptions about the nature of such coparticipation. The method is tested on EEG recordings obtained from Alzheimer's and Parkinson's disease patients, and matched healthy volunteers, for eyes-open and eyes-closed resting-state conditions, and the resulting functional networks are analysed through standard topological metrics.

Amino acids in the polymerase complex of shorebird-isolated H1N1 influenza virus impact replication and host-virus interactions in mammalian models.

A diverse population of avian influenza A viruses (AIVs) are maintained in wild birds and ducks yet the zoonotic potential of AIVs in these environmental reservoirs and the host-virus interactions involved in mammalian infection are not well understood. In studies of a group of subtype H1N1 AIVs isolated from migratory wild birds during surveillance in North America, we previously identified eight amino acids in the polymerase genes PB2 and PB1 that were important for the transmissibility of these AIVs in a ferret model of human influenza virus transmission. In this current study we found that PB2 containing amino acids associated with transmissibility at 67, 152, 199, 508, and 649 and PB1 at 298, 642, and 667 were associated with more rapid viral replication kinetics, greater infectivity, more active polymerase complexes and greater kinetics of viral genome replication and transcription.

Symbiotic microparticles produced through spray-drying-induced in situ alginate crosslinking for the preservation of Pediococcus pentosaceus viability.

Probiotic microorganisms are a promising alternative to antibiotics in preventing and treating bacterial infections. Within the probiotic group, the lactic acid bacteria (LAB)stand out for their health benefits and for being recognized as safe by regulatory agencies. However, these microorganisms are sensitive to various environmental conditions, including the acidic environment of the stomach.

Hemoadsorption Contribution in Failing Fontan Pediatric Heart Transplantation.

Introduction: A systemic inflammatory response is triggered in patients undergoing cardiothoracic surgery with cardiopulmonary bypass (CPB). This response is particularly evident in pediatric patients, especially those of low weight and after undergoing long CPB, and can severely impair the surgical result. Adsorptive blood purification techniques have been proposed to limit this systemic inflammatory response.

Effectiveness of epidural morphine for the treatment of cancer pain in patients with gastrointestinal neoplasm-a systematic review.

One-third of cancer pain patients do not experience adequate pain relief using analgesic ladder by the World Health Organization. Interventional procedures, such as epidural morphine, have been considered. This study aimed to review the literature comparing the effects of epidural administration of morphine with the oral route.

The impact of pre-existing influenza antibodies and inflammatory status on the influenza vaccine responses in older adults.

Age-associated immune changes and pre-existing influenza immunity are hypothesized to reduce influenza vaccine effectiveness in older adults, although the contribution of each factor is unknown. Here, we constructed influenza-specific IgG landscapes and determined baseline concentrations of cytokines typically associated with chronic inflammation in older adults (TNF-α, IL-10, IL-6, and IFN-γ) in 30 high and 29 low influenza vaccine responders (HR and LR, respectively). In a background of high H3 antibody titers, vaccine-specific H3, but not H1, antibody titers were boosted in LRs to titers comparable to HRs.

Randomized phase II clinical trial of ruxolitinib plus simvastatin in COVID19 clinical outcome and cytokine evolution.

Background: Managing the inflammatory response to SARS-Cov-2 could prevent respiratory insufficiency. Cytokine profiles could identify cases at risk of severe disease.

Methods: We designed a randomized phase II clinical trial to determine whether the combination of ruxolitinib (5 mg twice a day for 7 days followed by 10 mg BID for 7 days) plus simvastatin (40 mg once a day for 14 days), could reduce the incidence of respiratory insufficiency in COVID-19.

Continuous ordinal patterns: Creating a bridge between ordinal analysis and deep learning.

We introduce a generalization of the celebrated ordinal pattern approach for the analysis of time series, in which these are evaluated in terms of their distance to ordinal patterns defined in a continuous way. This allows us to naturally incorporate information about the local amplitude of the data and to optimize the ordinal pattern(s) to the problem under study. This last element represents a novel bridge between standard ordinal analysis and deep learning, allowing the achievement of results comparable to the latter in real-world classification problems while also retaining the conceptual simplicity, computational efficiency, and easy interpretability of the former.

Markov-modulated model for landing flow dynamics: An ordinal analysis validation.

Air transportation is a complex system characterized by a plethora of interactions at multiple temporal and spatial scales; as a consequence, even simple dynamics like sequencing aircraft for landing can lead to the appearance of emergent behaviors, which are both difficult to control and detrimental to operational efficiency. We propose a model, based on a modulated Markov jitter, to represent ordinal pattern properties of real landing operations in European airports. The parameters of the model are tuned by minimizing the distance between the probability distributions of ordinal patterns generated by the real and synthetic sequences, as estimated by the Permutation Jensen-Shannon Distance.

On the complementarity of ordinal patterns-based entropy and time asymmetry metrics.

Entropy and time asymmetry are two intertwined aspects of a system's dynamics, with the production of entropy marking a clear direction in the temporal dimension. In the last few years, metrics to quantify both properties in time series have been designed around the same concept, i.e.

The contributing external load factors to internal load during small-sided games in professional rugby union players.

Introduction: This study aimed to investigate which external load variables were associated with internal load during three small-sided games (SSG) in professional rugby union players.

Methods: Forty professional rugby union players (22 forwards, 18 backs) competing in the English Gallagher Premiership were recruited. Three different SSGs were designed: one for backs, one for forwards, and one for both backs and forwards.

Understanding small-scale COVID-19 transmission dynamics with the Granger causality test.

Mobility patterns have been broadly studied and deeply altered due to the coronavirus disease (COVID-19). In this paper, we study small-scale COVID-19 transmission dynamics in the city of Valencia and the potential role of subway stations and healthcare facilities in this transmission. A total of 2,398 adult patients were included in the analysis.

Designing a small-sided game to elicit attacking tactical behaviour in professional rugby union forwards.

This study aimed to investigate the consistency of attacking tactical and technical behaviour, and physical characteristics, over multiple bouts, and variability across days, of a specific rugby union forwards small-sided game (SSG). Data was collected from 21 professional rugby union forwards during four training sessions. The SSG, consisting of five bouts of work (150-s) interspersed by passive recovery (75-s), aimed to elicit specific attacking tactical behaviour.