A modified measurement method for functional spinal unit ROM of cervical spine.

The interspinous process motion (ISM) method can provide a more accurate assessment of postoperative subaxial cervical fusion than Cobb angle method which is used more commonly in clinical practice. However, the ISM method presents the measurement results in millimeters which cannot be directly compared with the Cobb angle measurement data. We proposed a modified measurement method for cervical functional spinal unit range of motion  (FSU ROM) and evaluate its repeatability and reliability in measuring the ROM of the surgical segment after cervical artificial disc replacement surgery.

Distribution and Epidemiological Characteristics of Clinical Isolates of in a Hospital from 2021 to 2023: A Retrospective Study.

Objective: The distribution characteristics of clinical isolates of were analyzed to provide the basis for the prevention and control of infection.

Methods: From January 2021 to December 2023, the First Affiliated Hospital of Nanjing Medical University collected clinical isolates of from hospitalized patients for study. Duplicate strains from the same patient in the same area were eliminated, and community-, hospital-, and colonization infections were grouped.

[Risk factors of coronal imbalance following posterior lumbar short-level fixation and fusion for degenerative lumbar scoliosis].

To explore the risk factors associated with coronal imbalance following posterior short-level fixation and fusion surgery for patients with degenerative lumbar scoliosis (DLS). A retrospective analysis was conducted on the clinical data of patients who underwent posterior short-level fixation and fusion for the treatment of DLS at Shanghai Changzheng Hospital from January 2018 to December 2022. The postoperative follow-up period was 12 months.

Bathing with 2% chlorhexidine gluconate versus routine care for preventing surgical site infections after pancreatic surgery: a single-centre randomized controlled trial.

Objectives: The study aims to investigate whether bathing with 2% chlorhexidine gluconate (CHG) reduces the incidence of surgical site infection (SSI) in patients undergoing routine pancreatic surgery.

Methods: A randomized controlled trial was conducted at a large-volume pancreatic centre between 1 January 2021 and 31 December 2022. Patients undergoing clean-contaminated pancreatic surgery were enrolled and randomized into an intervention arm (bathing with a 2% CHG wipe) and a control arm (routine care, soap, and water).

[Multiproxy Comprehensive Analysis for Source Apportionment and Pollution of Heavy Metals in Urban Drinking-water Source Soils from the Lanzhou Reach of the Yellow River].

To elucidate the pollution characteristics and sources of heavy metals in the soil of drinking water sources in urban areas of the Yellow River Basin, the soil in the water source areas for urban drinking water in the Lanzhou section of the Yellow River was selected as the research object. The content characteristics of heavy metals, including As, Cd, Cr, Hg, and Pb, were analyzed. The pollution degree of heavy metals was quantified systematically using the geo-accumulation index, contamination factor, pollution load index, and improved Nemerow comprehensive pollution index.

RrWRKY1, a Transcription Factor, Is Involved in the Regulation of the Salt Stress Response in .

Salt stress has become a major environmental problem affecting plant growth and development. Some WRKY transcription factors have been reported to be involved in the salt stress response in plants. However, there are few studies on the involvement of WRKYs in the salt stress response in .

Dynamic functional network connectivity and its association with lipid metabolism in Alzheimer's disease.

Aims: The study aims to examine the changing trajectory characteristics of dynamic functional network connectivity (dFNC) and its correlation with lipid metabolism-related factors across the Alzheimer's disease (AD) spectrum populations.

Methods: Data from 242 AD spectrum subjects, including biological, neuroimaging, and general cognition, were obtained from the Alzheimer's Disease Neuroimaging Initiative for this cross-sectional study. The study utilized a sliding-window approach to assess whole-brain dFNC, investigating group differences and associations with biological and cognitive factors.

A flexible resistive strain gauge with reduced temperature effect via thermal expansion anisotropic composite substrate.

Strain gauge plays vital roles in various fields as structural health monitoring, aerospace engineering, and civil infrastructure. However, traditional flexible strain gauge inevitably brings the pseudo-signal caused by the substrate temperature effect and determines its accuracy. Here, we present an anisotropic composite substrate designed to modify the thermal expansion performance via Micro-electro-mechanical System (MEMS) technology, which facilitates the development of strain gauges that are minimally affected by substrate temperature-induced effect.

Cardiotoxicity of Anticancer Drugs: Molecular Mechanisms, Clinical Management and Innovative Treatment.

With the continuous refinement of therapeutic measures, the survival rate of tumor patients has been improving year by year, while cardiovascular complications related to cancer therapy have become increasingly prominent. Exploring the mechanism and prevention strategy of cancer therapy-related cardiovascular toxicity (CTR-CVT) remains one of the research hotspots in the field of Cardio-Oncology in recent years. Cardiotoxicity of anticancer drugs involves heart failure, myocarditis, hypertension, arrhythmias and vascular toxicity, mechanistically related to vascular endothelial dysfunction, ferroptosis, mitochondrial dysfunction and oxidative stress.

From bioinformatics to clinical applications: a novel prognostic model of cuproptosis-related genes based on single-cell RNA sequencing data in hepatocellular carcinoma.

Objective And Methods: To ascertain the connection between cuproptosis-related genes (CRGs) and the prognosis of hepatocellular carcinoma (HCC) via single-cell RNA sequencing (scRNA-seq) and RNA sequencing (RNA-seq) data, relevant data were downloaded from the GEO and TCGA databases. The differentially expressed CRGs (DE-CRGs) were filtered by the overlaps in differentially expressed genes (DEGs) between HCC patients and normal controls (NCs) in the scRNA-seq database, DE-CRGs between high- and low-CRG-activity cells, and DEGs between HCC patients and NCs in the TCGA database.

Results: Thirty-three DE-CRGs in HCC were identified.

[Identification Priority Source of Heavy Metals in Urban Soils Based on Source-specific Ecological Risk Analysis in a Typical Tourist City].

To understand the pollution status, distribution characteristics, and pollution sources of soil heavy metals in tourist cities in northwest China, the soil content of heavy metals As, Cd, Cr, Cu, Hg, Ni, Pb, and Zn in the main areas of Dunhuang City was collected and analyzed. The soil heavy metal pollution level was quantitatively evaluated by the methods of the geo-accumulation index and improved Nemerow pollution index, and the sources of heavy metal pollution were quantitatively analyzed using cluster analysis and the positive matrix factorization （PMF） model. The contribution rate of each pollution source to ecological risk was determined by combining the PMF model and comprehensive ecological risk index.

A self-reported symptom-based decision-making model helps to rule out outpatient cases at low risk for CRC before colonoscopy.

Objectives: Effective exclusion of low-risk symptomatic outpatient cases for colorectal cancer (CRC) remains diagnostic challenges. We aimed to develop a self-reported symptom-based decision-making model for application in outpatient scenarios.

Methods: In total, 8233 symptomatic cases at risk for CRC, as judged by outpatient physicians, were involved in this study at seven medical centers.

Simultaneous immobilization of multiple heavy metal(loid)s in contaminated water and alkaline soil inoculated Fe/Mn oxidizing bacterium.

Two strains of Fe/Mn oxidizing bacteria tolerant to high concentrations of multiple heavy metal(loid)s and efficient decontamination for them were screened. The surface of the bio-Fe/Mn oxides produced by the oxidation of Fe(II) and Mn(II) by Pseudomonas taiwanensis (marked as P4) and Pseudomonas plecoglossicida (marked as G1) contains rich reactive oxygen functional groups, which play critical roles in the removal efficiency and immobilization of heavy metal(loid)s in co-contamination system. The isolated strains P4 and G1 can grow well in the following environments: pH 5-9, NaCl 0-4%, and temperature 20-30°C.

Neuroimmune modulating and energy supporting nanozyme-mimic scaffold synergistically promotes axon regeneration after spinal cord injury.

Spinal cord injury (SCI) represents a profound central nervous system affliction, resulting in irreversibly compromised daily activities and disabilities. SCI involves excessive inflammatory responses, which are characterized by the existence of high levels of proinflammatory M1 macrophages, and neuronal mitochondrial energy deficit, exacerbating secondary damage and impeding axon regeneration. This study delves into the mechanistic intricacies of SCI, offering insights from the perspectives of neuroimmune regulation and mitochondrial function, leading to a pro-fibrotic macrophage phenotype and energy-supplying deficit.

Adherence to guidelines and central-line-associated bloodstream infection occurrence during insertion and maintenance of intravascular catheters: evidence from 20 tertiary hospitals.

Objective: To investigate adherence to intravascular catheter (IVC) insertion and maintenance guidelines in Chinese tertiary hospitals.

Methods: A cross-sectional questionnaire survey of adult inpatients with IVC placements was conducted from July to September 2022 in 20 tertiary hospitals in China. One clinical staff member from each department in each hospital was assigned to participate in the survey.

Implications of deduplication on the detection rates of multidrug-resistant organism (MDRO) in various specimens: insights from the hospital infection surveillance program.

Background: Currently, different guidelines recommend using different methods to determine whether deduplication is necessary when determining the detection rates of multidrug-resistant organisms (MDROs). However, few studies have investigated the effect of deduplication on MDRO monitoring data. In this study, we aimed to investigate the influence of deduplication on the detection rates of MDROs in different specimens to assess its impact on infection surveillance outcomes.

Recalcification stabilizes cadmium but magnifies phosphorus limitation in wastewater-irrigated calcareous soil.

Long-term wastewater irrigation leads to the loss of calcium carbonate (CaCO) in the tillage layer of calcareous land, which irreversibly damages the soil's ability to retain cadmium (Cd). In this study, we selected calcareous agricultural soil irrigated with wastewater for over 50 years to examine the recalcification effects of sugar beet factory lime (SBFL) at doses of 0%, 2.5%, 5%, and 10%.

Macrophage-coated tumor cluster aggravates hepatoma invasion and immunotherapy resistance via generating local immune deprivation.

Immune checkpoint inhibitors (ICIs) represent a promising treatment for hepatocellular carcinoma (HCC) due to their capacity for abundant lymphocyte infiltration. However, some patients with HCC respond poorly to ICI therapy due to the presence of various immunosuppressive factors in the tumor microenvironment. Our research reveals that a macrophage-coated tumor cluster (MCTC) signifies a unique spatial structural organization in HCC correlating with diminished recurrence-free survival and overall survival in a total of 572 HCC cases from 3 internal cohorts and 2 independent external validation cohorts.

Responses of keratinocytes to Trichophyton mentagrophyte infection based on whole transcriptome analysis.

Background: Dermatophytosis is an intractable superficial mycosis in humans and animals mainly caused by Trichophyton mentagrophytes (T. mentagrophytes), with a global prevalence of about 20%. Keratinocytes are the most abundant participants in skin immunity, and they also play a role in the first-line defence against T.

Importance of Friendship and Minimal Group Membership in 4-6-Year-olds' and 9-12-Year-olds' Sharing Behavior in China.

Strategies for favoring close others, such as friends and in-group members, benefit individuals and society. Although younger and older children apply these sharing strategies, how they integrate these relationships remain understudied. Friendship and group membership sometimes conflict (e.

Metformin-grafted polycaprolactone nanoscaffold targeting sensory nerve controlled fibroblasts reprograming to alleviate epidural fibrosis.

Epidural fibrosis (EF), associated with various biological factors, is still a major troublesome clinical problem after laminectomy. In the present study, we initially demonstrate that sensory nerves can attenuate fibrogenic progression in EF animal models via the secretion of calcitonin gene-related peptide (CGRP), suggesting a new potential therapeutic target. Further studies showed that CGRP could inhibit the reprograming activation of fibroblasts through PI3K/AKT signal pathway.

CRA-Net: Transformer guided category-relation attention network for diabetic retinopathy grading.

Automated grading of diabetic retinopathy (DR) is an important means for assisting clinical diagnosis and preventing further retinal damage. However, imbalances and similarities between categories in the DR dataset make it highly challenging to accurately grade the severity of the condition. Furthermore, DR images encompass various lesions, and the pathological relationship information among these lesions can be easily overlooked.