Colorectal Metastasis From Lung Adenocarcinoma With Initial Gastrointestinal Symptoms: A Case Report and Literature Review.

Lung cancer (LC) is a malignant tumor with high morbidity and mortality. Nearly 50% of patients with primary LC have distant metastases at the time of initial diagnosis. LC usually metastasizes from the lungs to the liver, adrenal glands, brain, and bone, but rarely to the gastrointestinal (GI) tract.

[Evidence mapping of clinical research on traditional Chinese medicine in treatment of idiopathic pulmonary fibrosis].

This study systematically retrieved the clinical studies in the treatment of idiopathic pulmonary fibrosis(IPF) with traditional Chinese medicine(TCM) and employed evidence mapping to summarize the overall research status and deficiencies of TCM in treating IPF. CNKI, VIP, SinoMed, Wanfang, PubMed, Web of Science, Cochrane Library, and EMbase were searched for the relevant studies published from inception to February 20, 2024. The distribution characteristics of the evidence were analyzed and presented through charts combined with words.

Exogenous melatonin improves drought stress tolerance via regulating tryptophan metabolism and flavonoid biosynthesis pathways in wheat.

Melatonin (MT) serves an indispensable function in plant development and their response to abiotic stress. Although numerous drought-tolerance genes have been ascertained in wheat, further investigation into the molecular pathways controlling drought stress tolerance remains necessary. In this investigation, it was observed that MT treatment markedly enhanced drought resistance in wheat by diminishing malondialdehyde (MDA) levels and augmenting the activity of antioxidant enzymes POD, APX, and CAT compared to untreated control plants.

A motor imagery classification model based on hybrid brain-computer interface and multitask learning of electroencephalographic and electromyographic deep features.

Objective: Extracting deep features from participants' bioelectric signals and constructing models are key research directions in motor imagery (MI) classification tasks. In this study, we constructed a multimodal multitask hybrid brain-computer interface net (2M-hBCINet) based on deep features of electroencephalogram (EEG) and electromyography (EMG) to effectively accomplish motor imagery classification tasks.

Methods: The model first used a variational autoencoder (VAE) network for unsupervised learning of EEG and EMG signals to extract their deep features, and subsequently applied the channel attention mechanism (CAM) to select these deep features and highlight the advantageous features and minimize the disadvantageous ones.

Predictive Value of the nProfiler 1 Assay for the Efficacy of Adjuvant S-1-Based Doublet Chemotherapy in Stage III Gastric Cancer: A Post-Hoc Analysis of a Randomized Phase III Trial.

Purpose: The nProfiler 1 Stomach Cancer Assay (nProfiler1), designed to predict responses to fluorouracil-based adjuvant chemotherapy, measures the expression of four gastric cancer target genes (GZMB, WARS, SFRP4, and CDX1). The randomized phase III POST trial aimed to compare the efficacies of two adjuvant S-1-based doublet chemotherapies: S-1 plus cisplatin (SP) and S-1 plus docetaxel (DS). This study aimed to validate the nProfiler1 assay using a distinct cohort from the POST trial.

RrWRKY1, a Transcription Factor, Is Involved in the Regulation of the Salt Stress Response in .

Salt stress has become a major environmental problem affecting plant growth and development. Some WRKY transcription factors have been reported to be involved in the salt stress response in plants. However, there are few studies on the involvement of WRKYs in the salt stress response in .

Spectral peak analysis and intrinsic neural timescales as markers for the state of consciousness.

Resting state EEG in patients with disorders of consciousness (DOC) is characterized by an increase of power in the delta frequency band and a concurrent decrease in the alpha range, equivalent to a weakening or disappearance of the alpha peak. Prolongation of Intrinsic Neural Timescales (INTs) is also associated with DOCs. Together, this raises the question whether the decreased alpha peak relates to the prolonged INTs and, importantly, how that can be used for diagnosing the state of consciousness in DOC individuals.

Pharmacokinetics of Vancomycin in Healthy Korean Volunteers and Monte Carlo Simulations to Explore Optimal Dosage Regimens in Patients with Normal Renal Function.

: To date, population pharmacokinetic (PK) studies of vancomycin on healthy Korean adults have not been conducted. This study aimed to investigate the PK properties of vancomycin in healthy volunteers and to identify optimal dosing regimens based on the area under the concentration-time curve (AUC) in adult patients with normal renal function. : We conducted a prospective clinical study, analysing PK samples from 12 healthy participants using noncompartmental analysis and non-linear mixed-effects modelling.

Association between Tumor Size at the Time of Disease Progression and Survival Outcomes.

Purpose: This study evaluates the prognostic significance of tumor size at disease progression (PD) and depth of response (DOR) in cancer patients.

Materials And Methods: We performed post hoc analysis using data from six prospective clinical trials conducted by the Korean Cancer Study Group. Patients with tumor size at PD was categorized into 'Mild PD' and 'Significant PD' based on the cutoff values of relative change from baseline using maximally selected rank statistics.

Classifying disorders of consciousness using a novel dual-level and dual-modal graph learning model.

Background: Disorders of consciousness (DoC) are a group of conditions that affect the level of awareness and communication in patients. While neuroimaging techniques can provide useful information about the brain structure and function in these patients, most existing methods rely on a single modality for analysis and rarely account for brain injury. To address these limitations, we propose a novel method that integrates two neuroimaging modalities, functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI), to enhance the classification of subjects into different states of consciousness.

Removal of sulfamethoxazole in an algal-bacterial membrane aerated biofilm reactor: Microbial responses and antibiotic resistance genes.

Antibiotics are frequently detected in wastewater, but often are poorly removed in conventional wastewater treatment processes. Combining microalgal and nitrifying bacterial processes may provide synergistic removal of antibiotics and ammonium. In this research, we studied the removal of the antibiotic sulfamethoxazole (SMX) in two different reactors: a conventional nitrifying bacterial membrane aerated biofilm reactor (bMABR) and algal-bacterial membrane aerated biofilm reactor (abMABR) systems.

Atomization by Acoustic Levitation Facilitates Contactless Microdroplet Reactions.

Microdroplet chemistry is now well-known to be able to remarkably accelerate otherwise slow reactions and trigger otherwise impossible reactions. The uniqueness of the microdroplet is attributable to either the air-water interface or solid-liquid interface, depending on the medium that the microdroplet is in contact with. To date, the importance of the solid-liquid interface might have been confirmed, but the contribution from the air-water interface seems to be elusive due to the lack of method for generating contactless microdroplets.

Genome-Wide Identification and Expression Analysis of the Gene Superfamily Provides Insight into Sex Determination and Early Gonadal Development of .

The gene superfamily is widely distributed among higher eukaryotes and plays a significant role in numerous biological processes. However, there is limited knowledge about the structure and function of genes in the critically endangered species , which is endemic to China. A total of 170 genes were identified from the genome, classified into 13 families, and unevenly distributed across 16 chromosomes.

Precision Dosing of Meropenem in Adults with Normal Renal Function: Insights from a Population Pharmacokinetic and Monte Carlo Simulation Study.

This study aimed to develop a population pharmacokinetic (PK) model for meropenem in healthy adults and explore optimal dosing regimens for patients with normal renal function. PK samples were obtained from 12 healthy participants, which were analyzed using noncompartmental analysis and nonlinear mixed-effect modeling. The PK profiles of meropenem were characterized using a two-compartment model, and serum creatinine level was identified as a significant covariate affecting total clearance.

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Background: In recent years, China has actively promoted the publicity and promotion of breastfeeding, because breastfeeding is conducive to the healthy growth of babies and conducive to the recovery of maternal health. Behavioral nursing theory holds that individual behavior change is a complex and continuous process, and personalized care is given at different stages of individual behavior change to promote individual behavior change.

Objective: To explore the impact of behavioral nursing intervention on the breastfeeding maintenance rate of hospitalized newborns.

The Chinese visceral adiposity index: a novel indicator more closely related to cardiovascular disease than other abdominal obesity indices among postmenopausal women.

Background: Several abdominal obesity indices including waist circumference (WC), waist-hip ratio (WHR), visceral adiposity index (VAI), lipid accumulation product (LAP), and Chinese visceral adiposity index (CVAI) were considered effective and useful predictive markers for cardiovascular disease (CVD) in general populations or diabetic populations. However, studies investigating the associations between these indices among postmenopausal women are limited. Our study aimed to investigate the associations of the five indices with incident CVD and compare the predictive performance of CVAI with other abdominal obesity indices among postmenopausal women.

Nationwide precision oncology pilot study: KOrean Precision Medicine Networking Group Study of MOlecular profiling-guided therapy based on genomic alterations in advanced solid tumors (KOSMOS) KCSG AL-20-05.

Background: Next-generation sequencing (NGS) has become widely available but molecular profiling-guided therapy (MGT) had not been well established in the real world due to lack of available therapies and expertise to match treatment. Our study was designed to test the feasibility of a nationwide platform of NGS-guided MGT recommended by a central molecular tumor board (cMTB) for metastatic solid tumors.

Patients And Methods: Patients with advanced or metastatic solid tumors with available NGS results and without standard treatment were enrolled.

Study on the antidepressant activity of (2R,6R; 2S,6S)-Hydroxynorketamine (HNK) and its derivatives.

Objective: This study mainly explores (2R,6R; 2S,6S)-HNK and its compounds whether there are antidepressant effects.

Methods: Four HNK compounds were obtained from 2-(Chlorophenyl) Cyclopentylmethanone. Forced swimming test, locomotor sensitization test, and conditioned location preference test were used to screen the antidepressant activity of the synthesized target compounds.

Visible Light-Activated Room Temperature NO Gas Sensing Based on the InO@ZnO Heterostructure with a Hollow Microtube Structure.

The persistent challenge of poor recovery characteristics of NO sensors operated at room temperature remains significant. However, the development of InO-based gas sensing materials provides a promising approach to accelerate response and recovery for sub-ppm of NO detection at room temperature. Herein, we propose a simple two-step method to synthesize a one-dimensional (1D) InO@ZnO heterostructure material with hollow microtubes, by coupling metal-organic frameworks (MOFs) (MIL-68 (In)) and zinc ions.