p90RSK2, a new MLCK mediates contractility in myosin light chain kinase null smooth muscle.

Phosphorylation of smooth muscle (SM) myosin regulatory light chain (RLC) is a critical switch leading to SM contraction. The canonical view held that only the short isoform of myosin light chain kinase (MLCK1) catalyzed this reaction. It is now accepted that auxiliary kinases may contribute to vascular SM tone and contractility.

p90RSK2, a new MLCK, rescues contractility in myosin light chain kinase null smooth muscle.

Background: Phosphorylation of smooth muscle (SM) myosin regulatory light chain (RLC ) is a critical switch leading to contraction or cell migration. The canonical view held that the only kinase catalyzing this reaction is the short isoform of myosin light chain kinase (MLCK1). Auxiliary kinases may be involved and play a vital role in blood pressure homeostasis.