Publications by authors named "Zandra Chew Yann"
Biofactors
September 2022
Article Synopsis
- Complexes formed by alpha-lactalbumin's N-terminal peptide and oleic acid interact with lipid bilayers, leading to tumor cell death while normal cells are more resistant due to less significant membrane effects.
- Bladder cancer tissue has higher unsaturated lipids, particularly in phosphatidylcholine and sphingomyelin, compared to healthy tissue, which has more saturated lipids, contributing to the enhanced resistance of healthy cells against the tumoricidal complex.
- The study suggests that the unsaturated lipids in cancer cells might act as specific "recognition motifs" for molecules like alpha1-oleate, thereby highlighting the importance of membrane lipid composition in tumor cell susceptibility.
