Indomethacin (INDO) is a synthetic non-steroidal antipyretic, analgesic, and anti-inflammatory drug that commonly exists in both amorphous and crystalline states. Its amorphous state (A-INDO) is utilized by pharmaceutical companies as an active pharmaceutical ingredient (API) in the production of INDO drugs due to its higher apparent solubility and bioavailability. The crystal state also encompasses various crystal forms such as the α-crystal form (α-INDO) and γ-crystal form (γ-INDO), with the highly crystalline and insoluble γ-INDO being commercially available.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
April 2024
Canagliflozin (CFZ) tablets was a commercially new class of anti-diabetic drug, CFZ had various anhydrate crystal forms and two hydrate crystal forms (Canagliflozin hemihydrate (Hemi-CFZ) and Canagliflozin monohydrate (Mono-CFZ) crystal form). The active pharmaceutical ingredients (APIs) of commercially available CFZ tablets were Hemi-CFZ, was easily convert to CFZ or Mono-CFZ under the influence of temperature, pressure, humidity and other factors in tablets processing, storage, and transportation, thus affected bioavailability and efficacy of tablets. Therefore, quantitative analysis of low-content CFZ and Mono-CFZ in tablets was essential to control tablets' quality.
View Article and Find Full Text PDFProstate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.
View Article and Find Full Text PDFIn the version of this article initially published, the name of author Manuela Gago-Dominguez was misspelled as Manuela Gago Dominguez. The error has been corrected in the HTML and PDF version of the article.
View Article and Find Full Text PDFUnprecedented lanthanide (Ln)-radical loop-chain coordination polymers were achieved using multidentate pyridyl- or triazole- substituted nitronyl nitroxide ligands. Their magnetic units consist of ferromagnetic [LnRadical] moieties, leading for the dysprosium(III) derivatives to slow relaxation of magnetization, which was found to be dependent on the heterocyclic ligands.
View Article and Find Full Text PDFProstate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis.
View Article and Find Full Text PDFGenome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 PrCa cases and 27,910 controls of European ancestry with previously genotyped data of 32,255 PrCa cases and 33,202 controls of European ancestry. Our analysis identified 62 novel loci associated (P < 5.
View Article and Find Full Text PDFNorepinephrine (NE) can regulate natural killer (NK) cell activity, but the mechanism remains unclear. In the present study the roles of adrenergic receptors (ARs) in inhibiting NK92‑MI cells‑mediated cytotoxicity by NE were investigated. To examine the effect of NE on NK92‑MI cytotoxicity, a lactate dehydrogenase‑release cytotoxicity assay was used to determine the cytotoxicity of NK92‑MI cells against K562 cells.
View Article and Find Full Text PDFFunctionalized nitronyl nitroxide biradical ligands incorporating pyridine groups hold Co and Ln ions together, creating biradical-based 3d-4f tetranuclear complexes [LnCo(hfac)(NITPhPybis)] [Ln = Gd (1), Tb (2), Dy (3), and Ho (4); NITPhPybis = 5-(4-pyridyl)-1,3-bis(1'-oxyl-3'-oxido-4',4',5',5'-tetramethyl-4,5-hydro-1 H-imidazol-2-yl)benzene; hfac = hexafluoroacetylacetonate]. These complexes have a centrosymmetric cyclic molecular structure in which two biradicals perform as tetradentate ligands to bind two Co and two Ln ions, resulting in a rare octaspin system. Direct-current (dc) magnetic susceptibility studies reveal that the strong antiferromagnetic Co-NO magnetic exchange dominates the present magnetic system, while magnetic coupling of Gd-ON is ferromagnetic.
View Article and Find Full Text PDFLadder-type and chain 2p-3d-4f complexes based on a bridging nitronyl nitroxide radical, namely, [LnCu(hfac)(NIT-Ph-p-OCHtrz)]·0.5CH [Ln = Y (1a), Dy (1b)] and [LnCu(hfac)(NIT-Ph-p-OCHtrz)] [Ln = Y (2a), Dy (2b); NIT-Ph-p-OCHtrz = 2-[4-[(1H-1,2,4-triazol-1-yl)methoxy]phenyl]-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide; hfac = hexafluoroacetylacetonate) have been successfully achieved through a one-pot reaction of the NIT-Ph-p-OCHtrz radical with Cu(hfac) and Ln(hfac)·2HO. Complexes 1a and 1b feature a ladder-like structure, where the rails are made of Ln(III) and Cu(II) ions alternatively bridged by nitronyl nitroxide and the triazole units while the NIT-Ph-p-OCHtrz moieties act as the rungs of the ladder.
View Article and Find Full Text PDFA novel lanthanide(iii)-nitronyl nitroxide chain {[Gd(hfac)(Nit-Ph-3,5-bIm)(HO)]·CHO} (1) was prepared and characterized. Strikingly, an unexpected ferromagnetic coupling between the Gd(iii) ion and the nitroxide group mediated by hydrogen bonding has been observed for the first time.
View Article and Find Full Text PDFProstate cancer predisposition has been extensively investigated in European populations, but there have been few studies of other ethnic groups. To investigate prostate cancer susceptibility in the under-investigated Chinese population, we performed single-nucleotide polymorphism (SNP) array analysis on a cohort of Chinese cases and controls and then meta-analysis with data from the existing Chinese prostate cancer genome-wide association study (GWAS). Genotyping 211,155 SNPs in 495 cases and 640 controls of Chinese ancestry identified several new suggestive Chinese prostate cancer predisposition loci.
View Article and Find Full Text PDFActa Crystallogr Sect E Struct Rep Online
March 2013
The asymmetric unit of the title salt, (C8H10N3)[FeCl4], contains one 1,3-dimethyl-1H-1,2,3-benzotriazol-3-ium cation and one tetra-chloridoferrate anion. The Fe(III) atom in the anion is tetra-hedrally coordinated by four Cl atoms. In the crystal, inter-actions are observed between the Cl atoms and the triazolium ring [Cl⋯centroid distances = 3.
View Article and Find Full Text PDFActa Crystallogr Sect E Struct Rep Online
July 2012
In the title complex, [Ni(C₆H₆N₃O)(NCS)(C₆H₇N₃O)(H₂O)] or [Ni(mpko)(SCN)(mpkoH)(H₂O)] [where mpkoH = 1-(pyrazin-2-yl)ethanone oxime], the Ni(II) cation is in a slightly distorted octa-hedral geometry, being coordinated in the equatorial plane by four N atoms from two different mpkoH ligands, one of which is deprotonated, and by one N atom from a thio-cyanate anion and one O atom from a water mol-ecule in the axial positions. There is an intra-molecular O-H⋯O hydrogen bond involving the oxime units of the two ligands. In the crystal, a three-dimensional supra-molecular architecture is formed by O-H⋯O and O-H⋯N hydrogen bonds.
View Article and Find Full Text PDFActa Crystallogr Sect E Struct Rep Online
June 2012
The central Co(II) ion in the title complex, [Co(C(16)H(19)N(5))(2)](NO(3))(2), is located on a twofold rotation axis and has a slightly distorted octa-hedral coordination sphere. It is bonded to six N atoms from two 2-[bis-(3,5-dimethyl-1H-pyrazol-1-yl)meth-yl]pyridine ligands. In the crystal, mol-ecules are linked by weak C-H⋯O inter-actions.
View Article and Find Full Text PDFSichuan Da Xue Xue Bao Yi Xue Ban
May 2011
Objective: To study the effect of Loa22 mature peptide on the apoptosis of A549 to explore the mechanism of pulmonary impairment in severe forms of leptospirosis.
Methods: Loa22 mature peptide (100 microg/mL) was administered to culture with human lung adenocarcinoma cell line (A549). After 24 hours, the apoptosis, the concentration of calcium of the cells were evaluated.
It is believed that the mechanisms of aging or longevity are multifactorial. We selected four major postnatal factors to verify the mechanisms of longevity and aging. Type B behavior is strongly associated with longevity.
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