Publications by authors named "Zan Qureshi"
Diverse DNA-deforming processes are impacted by the local mechanical and structural properties of DNA, which in turn depend on local sequence and epigenetic modifications. Deciphering this mechanical code (that is, this dependence) has been challenging due to the lack of high-throughput experimental methods. Here we present a comprehensive characterization of the mechanical code.
View Article and Find Full Text PDFMechanical deformations of DNA such as bending are ubiquitous and have been implicated in diverse cellular functions. However, the lack of high-throughput tools to measure the mechanical properties of DNA has limited our understanding of how DNA mechanics influence chromatin transactions across the genome. Here we develop 'loop-seq'-a high-throughput assay to measure the propensity for DNA looping-and determine the intrinsic cyclizabilities of 270,806 50-base-pair DNA fragments that span Saccharomyces cerevisiae chromosome V, other genomic regions, and random sequences.
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- * Traditional treatments for chronic OA are often inadequate, with surgery being the main definitive option, leaving many patients seeking alternatives.
- * A case study of an 81-year-old woman showed that water-cooled radiofrequency ablation can provide effective pain relief and improve function for patients with severe knee OA, with lasting benefits observed at 6 weeks and 3 months post-treatment.